AutismKB 2.0

Annotation Detail for NCOA1


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Basic Information Top
Gene Symbol:NCOA1 ( F-SRC-1,KAT13A,MGC129719,MGC129720,RIP160,SRC1,bHLHe42,bHLHe74 )
Gene Full Name: nuclear receptor coactivator 1
Band: 2p23.3
Quick LinksEntrez ID:8648; OMIM: 602691; Uniprot ID:NCOA1_HUMAN; ENSEMBL ID: ENSG00000084676; HGNC ID: 7668
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst2 / 6231932
fetus62 / 564012109
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult111 / 193912157
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor14 / 26384553
glioma14 / 106883130
head and neck tumor6 / 13630244
kidney tumor6 / 6895987
leukemia12 / 95842125
liver tumor4 / 9635941
lung tumor2 / 10312719
lymphoma4 / 7175555
non-neoplasia4 / 9725041
normal223 / 336030766
ovarian tumor0 / 766820 
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma8 / 46356172
skin tumor7 / 12494956
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder1 / 2975733
blood8 / 12347864
bone4 / 7165555
bone marrow2 / 4880140
brain51 / 110098946
cervix0 / 481710 
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue7 / 21572232
esophagus0 / 202090 
eye33 / 211054156
heart6 / 8962666
intestine10 / 23447242
kidney17 / 21177780
larynx1 / 2414541
liver7 / 20774333
lung25 / 33697474
lymph1 / 4427022
lymph node9 / 9161098
mammary gland8 / 15327152
mouth1 / 6705214
muscle7 / 10771564
nerve5 / 15768317
ovary0 / 1020510 
pancreas3 / 21481213
parathyroid2 / 2053997
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta11 / 28082539
prostate7 / 18934536
salivary gland0 / 201550 
skin14 / 21057466
spleen5 / 5395292
stomach3 / 9661931
testis14 / 33044242
thymus2 / 8113124
thyroid4 / 4747384
tonsil1 / 1699958
trachea1 / 5241319
umbilical cord0 / 136800 
uterus6 / 23287825
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210249_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts42.55
Adipocyte61.65
AdrenalCortex78.95
Adrenalgland52.7
Amygdala66.05
Appendix56.95
AtrioventricularNode47.45
BDCA4+_DentriticCells122.85
Bonemarrow51.5
BronchialEpithelialCells36.95
CD105+_Endothelial35.95
CD14+_Monocytes141.85
CD19+_BCells(neg._sel.)89.2
CD33+_Myeloid115.35
CD34+65.2
CD4+_Tcells97.8
CD56+_NKCells228.95
CD71+_EarlyErythroid57.8
CD8+_Tcells73.7
CardiacMyocytes49.85
Caudatenucleus49.15
Cerebellum53.65
CerebellumPeduncles117.75
CiliaryGanglion47.95
CingulateCortex135.65
Colorectaladenocarcinoma41.2
DorsalRootGanglion47.9
FetalThyroid76.6
Fetalbrain67.85
Fetalliver51.9
Fetallung32
GlobusPallidus65.6
Heart69.45
Hypothalamus69.3
Kidney55.75
Leukemia_chronicMyelogenousK-56236.85
Leukemia_promyelocytic-HL-6033.05
Leukemialymphoblastic(MOLT-4)36.7
Liver81.5
Lung52.75
Lymphnode48.5
Lymphoma_burkitts(Daudi)58.7
Lymphoma_burkitts(Raji)56.7
MedullaOblongata89.45
OccipitalLobe80.65
OlfactoryBulb86.35
Ovary44.15
Pancreas47.9
PancreaticIslet71.9
ParietalLobe104.55
Pituitary106.7
Placenta46.5
Pons96.5
PrefrontalCortex195
Prostate55.4
Salivarygland50.2
SkeletalMuscle88.75
Skin47.95
SmoothMuscle61.6
Spinalcord64.75
SubthalamicNucleus137.65
SuperiorCervicalGanglion70.2
TemporalLobe72.7
Testis52.7
TestisGermCell109.9
TestisIntersitial64
TestisLeydigCell77.3
TestisSeminiferousTubule64.7
Thalamus62.15
Thymus77.55
Thyroid33.7
Tongue71.05
Tonsil74.4
Trachea42.65
TrigeminalGanglion62
Uterus51.05
UterusCorpus53.9
WholeBlood149.55
Wholebrain52.95
colon54.45
pineal_day122.5
pineal_night129.56
retina108.9
small_intestine60.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16687_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.82 ± 0.37
Basal Forebrain5.71 ± 0.62
Basal Part of Pons5.85 ± 0.39
Cerebellar Cortex5.98 ± 0.44
Cerebellar Nuclei5.11 ± 0.51
Claustrum5.15 ± 0.84
Epithalamus5.71 ± 0.46
Frontal Lobe5.8 ± 0.51
Globus Pallidus5.2 ± 0.33
Hypothalamus5.54 ± 0.54
Insula5.8 ± 0.4
Limbic Lobe5.89 ± 0.47
Mesencephalon5.63 ± 0.51
Myelencephalon5.71 ± 0.48
Occipital Lobe5.56 ± 0.46
Parietal Lobe5.69 ± 0.46
Pontine Tegmentum5.6 ± 0.46
Striatum5.64 ± 0.41
Subthalamus5.61 ± 0.4
Temporal Lobe5.89 ± 0.44
Thalamus5.69 ± 0.4
White Matter5 ± 0.46
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ncoa1CBCerebellum35.35
82.13
Ncoa1CTXCerebral cortex85.3
74.32
Ncoa1HIPHippocampal region85.69
100
Ncoa1HPFHippocampal formation74.5
100
Ncoa1HYHypothalamus16.2
13.37
Ncoa1LSXLateral septal complex25.85
21.66
Ncoa1MBMidbrain25.89
25.47
Ncoa1MYMedulla34.23
42.05
Ncoa1OLFOlfactory bulb70.3
65.1
Ncoa1PPons29.76
32.49
Ncoa1PALPallidum36.19
34.48
Ncoa1RHPRetrohippocampal region54.09
50.46
Ncoa1sAMYStriatum-like amygdalar nuclei49.16
39.25
Ncoa1STRStriatum66.05
53.74
Ncoa1STRdStriatum dorsal region68.71
55.71
Ncoa1STRvStriatum ventral region83.39
67.62
Ncoa1THThalamus67.07
67.26
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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