AutismKB 2.0

Annotation Detail for MAPKSP1


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Basic Information Top
Gene Symbol:MAPKSP1 ( MAP2K1IP1,MAPBP,MP1 )
Gene Full Name: MAPK scaffold protein 1
Band: 4q23
Quick LinksEntrez ID:8649; OMIM: 603296; Uniprot ID:MPKS1_HUMAN; ENSEMBL ID: ENSG00000109270; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus7 / 56401212
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult11 / 19391215
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor1 / 2638453
glioma1 / 1068839
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal18 / 33603075
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain4 / 11009893
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye1 / 2110544
heart0 / 896260 
intestine1 / 2344724
kidney1 / 2117774
larynx0 / 241450 
liver0 / 2077430 
lung3 / 3369748
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth1 / 6705214
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas1 / 2148124
parathyroid3 / 20539146
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate2 / 18934510
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach0 / 966190 
testis6 / 33044218
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 217971_at
Cell line Expression level Expression bar
721_B_lymphoblasts130.95
Adipocyte45.95
AdrenalCortex20.3
Adrenalgland17.5
Amygdala37.8
Appendix18.55
AtrioventricularNode15.1
BDCA4+_DentriticCells105.7
Bonemarrow19.3
BronchialEpithelialCells218.1
CD105+_Endothelial154.15
CD14+_Monocytes331.85
CD19+_BCells(neg._sel.)48.75
CD33+_Myeloid235.8
CD34+185.35
CD4+_Tcells21.65
CD56+_NKCells142.4
CD71+_EarlyErythroid112.75
CD8+_Tcells45.6
CardiacMyocytes42.15
Caudatenucleus20.4
Cerebellum10.55
CerebellumPeduncles18.25
CiliaryGanglion15.8
CingulateCortex31.25
Colorectaladenocarcinoma16.05
DorsalRootGanglion16.1
FetalThyroid37.9
Fetalbrain45.8
Fetalliver20.95
Fetallung34.5
GlobusPallidus18.35
Heart20.2
Hypothalamus55.15
Kidney16.6
Leukemia_chronicMyelogenousK-56225.55
Leukemia_promyelocytic-HL-6027.7
Leukemialymphoblastic(MOLT-4)44.85
Liver16.45
Lung19.7
Lymphnode41.8
Lymphoma_burkitts(Daudi)32.55
Lymphoma_burkitts(Raji)25.5
MedullaOblongata17.8
OccipitalLobe47.15
OlfactoryBulb28.3
Ovary16.5
Pancreas19.05
PancreaticIslet101.9
ParietalLobe21.4
Pituitary69.9
Placenta80.2
Pons16.95
PrefrontalCortex35.7
Prostate71.4
Salivarygland49.75
SkeletalMuscle22.2
Skin31.1
SmoothMuscle103.7
Spinalcord23.25
SubthalamicNucleus24
SuperiorCervicalGanglion25.15
TemporalLobe27.65
Testis18
TestisGermCell68.5
TestisIntersitial17.65
TestisLeydigCell33.45
TestisSeminiferousTubule37.4
Thalamus20
Thymus10.55
Thyroid130.9
Tongue41.05
Tonsil42.15
Trachea35.05
TrigeminalGanglion21.2
Uterus67.25
UterusCorpus28.8
WholeBlood375.55
Wholebrain35.1
colon136.95
pineal_day72.38
pineal_night70.82
retina40.65
small_intestine106.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P110362
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.97 ± 0.7
Basal Forebrain6.25 ± 0.21
Basal Part of Pons6.37 ± 0.26
Cerebellar Cortex6.37 ± 0.27
Cerebellar Nuclei6.19 ± 0.56
Claustrum5.87 ± 0.8
Epithalamus6.2 ± 0.59
Frontal Lobe6.44 ± 0.38
Globus Pallidus5.66 ± 0.29
Hypothalamus6.5 ± 0.35
Insula6.41 ± 0.33
Limbic Lobe6.14 ± 0.49
Mesencephalon6.17 ± 0.5
Myelencephalon6.11 ± 0.54
Occipital Lobe5.86 ± 0.53
Parietal Lobe6.23 ± 0.43
Pontine Tegmentum6.12 ± 0.54
Striatum5.82 ± 0.33
Subthalamus6.45 ± 0.17
Temporal Lobe6.29 ± 0.37
Thalamus6.15 ± 0.51
White Matter5.07 ± 0.21
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Map2k1ip1CBCerebellum18.64
29.33
Map2k1ip1CTXCerebral cortex10.51
8.07
Map2k1ip1HIPHippocampal region11.83
11.37
Map2k1ip1HPFHippocampal formation11.17
9.91
Map2k1ip1HYHypothalamus0.66
0.65
Map2k1ip1LSXLateral septal complex6.02
5.14
Map2k1ip1MBMidbrain5.68
6.77
Map2k1ip1MYMedulla11.3
16.3
Map2k1ip1OLFOlfactory bulb7.01
6.17
Map2k1ip1PPons6.83
10.16
Map2k1ip1PALPallidum0.75
0.75
Map2k1ip1RHPRetrohippocampal region10.36
8.02
Map2k1ip1sAMYStriatum-like amygdalar nuclei0.82
0.55
Map2k1ip1STRStriatum1.2
0.94
Map2k1ip1STRdStriatum dorsal region0.79
0.63
Map2k1ip1STRvStriatum ventral region1.41
0.99
Map2k1ip1THThalamus4.25
3.9
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
MPKS1_HUMAN_0 0 0 0 ELAPLFEELR PRIDE
MPKS1_HUMAN_0 0 0 0 KLPSVEGLHAIVVSDR PRIDE
MPKS1_HUMAN_0 0 0 0 VANDNAPEHALRPGFLSTFALATDQGSK PRIDE
MPKS1_HUMAN_108 10 108 117 ELAPLFEELR PRIDE
MPKS1_HUMAN_11 16 11 26 KLPSVEGLHAIVVSDR PRIDE
MPKS1_HUMAN_11 23 11 33 KLPSVEGLHAIVVSDRDGVPVIK PRIDE
MPKS1_HUMAN_12 22 12 33 LPSVEGLHAIVVSDRDGVPVIK PRIDE
MPKS1_HUMAN_34 28 34 61 VANDNAPEHALRPGFLSTFALATDQGSK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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