AutismKB 2.0

Annotation Detail for SOCS1


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Basic Information Top
Gene Symbol:SOCS1 ( CIS1,CISH1,JAB,SOCS-1,SSI-1,SSI1,TIP3 )
Gene Full Name: suppressor of cytokine signaling 1
Band: 16p13.13
Quick LinksEntrez ID:8651; OMIM: 603597; Uniprot ID:SOCS1_HUMAN; ENSEMBL ID: ENSG00000185338; HGNC ID: 19383
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus43 / 56401276
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult65 / 193912133
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor6 / 11424652
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor15 / 26384556
glioma7 / 10688365
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia3 / 9584231
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma3 / 7175541
non-neoplasia4 / 9725041
normal105 / 336030731
ovarian tumor28 / 76682365
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain8 / 11009897
cervix1 / 4817120
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye2 / 2110549
heart13 / 89626145
intestine9 / 23447238
kidney9 / 21177742
larynx0 / 241450 
liver0 / 2077430 
lung26 / 33697477
lymph3 / 4427067
lymph node21 / 91610229
mammary gland0 / 1532710 
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary28 / 102051274
pancreas10 / 21481246
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta8 / 28082528
prostate3 / 18934515
salivary gland0 / 201550 
skin2 / 2105749
spleen1 / 5395218
stomach0 / 966190 
testis2 / 3304426
thymus1 / 8113112
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209999_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.1
Adipocyte3.2
AdrenalCortex3.25
Adrenalgland2.7
Amygdala3.45
Appendix3.2
AtrioventricularNode2.4
BDCA4+_DentriticCells3.6
Bonemarrow3.15
BronchialEpithelialCells3.15
CD105+_Endothelial3.25
CD14+_Monocytes3.4
CD19+_BCells(neg._sel.)3.45
CD33+_Myeloid4.1
CD34+4.1
CD4+_Tcells3.5
CD56+_NKCells3.9
CD71+_EarlyErythroid3
CD8+_Tcells3.15
CardiacMyocytes4
Caudatenucleus2.85
Cerebellum2.6
CerebellumPeduncles3.65
CiliaryGanglion2.2
CingulateCortex3.25
Colorectaladenocarcinoma3.25
DorsalRootGanglion2.35
FetalThyroid3.15
Fetalbrain3.25
Fetalliver2.8
Fetallung2.8
GlobusPallidus2.3
Heart4.1
Hypothalamus3.55
Kidney2.6
Leukemia_chronicMyelogenousK-5622.95
Leukemia_promyelocytic-HL-602.9
Leukemialymphoblastic(MOLT-4)2.6
Liver4.2
Lung3.6
Lymphnode2.8
Lymphoma_burkitts(Daudi)4.05
Lymphoma_burkitts(Raji)22.45
MedullaOblongata2.95
OccipitalLobe2.9
OlfactoryBulb2.5
Ovary2.1
Pancreas2.55
PancreaticIslet4.85
ParietalLobe3.4
Pituitary3.8
Placenta3.4
Pons3.05
PrefrontalCortex4.1
Prostate3.8
Salivarygland2.5
SkeletalMuscle3.65
Skin2.4
SmoothMuscle3.7
Spinalcord3.4
SubthalamicNucleus2.9
SuperiorCervicalGanglion3.6
TemporalLobe2.95
Testis2.8
TestisGermCell2.7
TestisIntersitial2.7
TestisLeydigCell3.15
TestisSeminiferousTubule2.75
Thalamus3.25
Thymus2.6
Thyroid4.1
Tongue3.1
Tonsil3.15
Trachea2.7
TrigeminalGanglion3.15
Uterus2.65
UterusCorpus2.85
WholeBlood3.6
Wholebrain2.85
colon3.25
pineal_day4.04
pineal_night3.94
retina3.925
small_intestine3.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P48014
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.38 ± 0.97
Basal Forebrain2.12 ± 0.35
Basal Part of Pons1.67 ± 0.34
Cerebellar Cortex2.1 ± 0.73
Cerebellar Nuclei2.29 ± 0.68
Claustrum2.91 ± 0.85
Epithalamus1.77 ± 0.73
Frontal Lobe1.83 ± 0.59
Globus Pallidus2.37 ± 0.28
Hypothalamus1.99 ± 0.58
Insula2.03 ± 0.46
Limbic Lobe1.99 ± 0.61
Mesencephalon2.13 ± 0.65
Myelencephalon2.02 ± 0.62
Occipital Lobe2.13 ± 0.81
Parietal Lobe2.08 ± 0.72
Pontine Tegmentum2.12 ± 0.67
Striatum2.11 ± 0.58
Subthalamus2.15 ± 0.66
Temporal Lobe1.91 ± 0.61
Thalamus1.97 ± 0.58
White Matter2.39 ± 0.29
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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