AutismKB 2.0

Annotation Detail for PDE5A


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Basic Information Top
Gene Symbol:PDE5A ( CGB-PDE,CN5A,PDE5 )
Gene Full Name: phosphodiesterase 5A, cGMP-specific
Band: 4q26
Quick LinksEntrez ID:8654; OMIM: 603310; Uniprot ID:PDE5A_HUMAN; ENSEMBL ID: ENSG00000138735; HGNC ID: 8784
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst1 / 6231916
fetus30 / 56401253
neonate0 / 310970 
infant1 / 2362042
juvenile2 / 5555635
adult57 / 193912129
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma5 / 8282360
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor1 / 2638453
glioma0 / 1068830 
head and neck tumor2 / 13630214
kidney tumor7 / 68959101
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia2 / 9725020
normal118 / 336030735
ovarian tumor0 / 766820 
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain16 / 110098914
cervix0 / 481710 
connective tissue4 / 14925526
ear2 / 16212123
embryonic tissue9 / 21572241
esophagus1 / 2020949
eye6 / 21105428
heart4 / 8962644
intestine4 / 23447217
kidney10 / 21177747
larynx0 / 241450 
liver0 / 2077430 
lung8 / 33697423
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth0 / 670520 
muscle10 / 10771592
nerve1 / 1576863
ovary0 / 1020510 
pancreas4 / 21481218
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta12 / 28082542
prostate13 / 18934568
salivary gland2 / 2015599
skin1 / 2105744
spleen0 / 539520 
stomach4 / 9661941
testis14 / 33044242
thymus1 / 8113112
thyroid2 / 4747342
tonsil0 / 169990 
trachea6 / 52413114
umbilical cord0 / 136800 
uterus5 / 23287821
vascular10 / 51780193
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206757_at
Cell line Expression level Expression bar
721_B_lymphoblasts11.55
Adipocyte11
AdrenalCortex20.75
Adrenalgland11
Amygdala11.1
Appendix24.55
AtrioventricularNode21.1
BDCA4+_DentriticCells10.1
Bonemarrow16.45
BronchialEpithelialCells10.4
CD105+_Endothelial11.15
CD14+_Monocytes12.55
CD19+_BCells(neg._sel.)11.4
CD33+_Myeloid12.55
CD34+12.35
CD4+_Tcells9.85
CD56+_NKCells11.9
CD71+_EarlyErythroid11.8
CD8+_Tcells9.3
CardiacMyocytes26.6
Caudatenucleus10.45
Cerebellum9.7
CerebellumPeduncles15.8
CiliaryGanglion17.1
CingulateCortex13.45
Colorectaladenocarcinoma11.1
DorsalRootGanglion12.2
FetalThyroid13.6
Fetalbrain11.25
Fetalliver10.35
Fetallung8.35
GlobusPallidus11.4
Heart27.7
Hypothalamus10.7
Kidney12.5
Leukemia_chronicMyelogenousK-5629.95
Leukemia_promyelocytic-HL-609.9
Leukemialymphoblastic(MOLT-4)8.8
Liver23.75
Lung12.2
Lymphnode8.95
Lymphoma_burkitts(Daudi)17
Lymphoma_burkitts(Raji)20.9
MedullaOblongata9.95
OccipitalLobe10.1
OlfactoryBulb8.7
Ovary11.85
Pancreas11.7
PancreaticIslet13.35
ParietalLobe15.8
Pituitary14.05
Placenta10.15
Pons13.2
PrefrontalCortex11.85
Prostate12.45
Salivarygland10.5
SkeletalMuscle29.45
Skin16.9
SmoothMuscle13.05
Spinalcord12.25
SubthalamicNucleus13.5
SuperiorCervicalGanglion29.9
TemporalLobe12.05
Testis9.8
TestisGermCell8.85
TestisIntersitial11.45
TestisLeydigCell13.4
TestisSeminiferousTubule9.95
Thalamus12.9
Thymus8.4
Thyroid12.95
Tongue19.1
Tonsil12.55
Trachea9.35
TrigeminalGanglion23.8
Uterus8.65
UterusCorpus24.95
WholeBlood12.25
Wholebrain7.9
colon11.45
pineal_day13.2
pineal_night12.96
retina13.725
small_intestine10.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_11485_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.18 ± 0.62
Basal Forebrain4.37 ± 0.36
Basal Part of Pons5.31 ± 0.19
Cerebellar Cortex5.05 ± 0.48
Cerebellar Nuclei4.97 ± 0.55
Claustrum4.08 ± 0.8
Epithalamus4.49 ± 1.03
Frontal Lobe4.36 ± 0.78
Globus Pallidus5.09 ± 0.74
Hypothalamus4.9 ± 0.87
Insula4.54 ± 1.08
Limbic Lobe4.37 ± 0.65
Mesencephalon4.28 ± 0.69
Myelencephalon4.54 ± 0.83
Occipital Lobe4.67 ± 0.69
Parietal Lobe4.23 ± 0.73
Pontine Tegmentum4.53 ± 0.63
Striatum4.84 ± 0.82
Subthalamus4.14 ± 0.5
Temporal Lobe4.28 ± 0.74
Thalamus5.07 ± 0.76
White Matter4.11 ± 0.52
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Pde5aCBCerebellum23.32
97.95
Pde5aCTXCerebral cortex18.49
15.17
Pde5aHIPHippocampal region13.16
16.27
Pde5aHPFHippocampal formation12.89
13.61
Pde5aHYHypothalamus1.84
1.47
Pde5aLSXLateral septal complex1.55
1.59
Pde5aMBMidbrain4.63
4.51
Pde5aMYMedulla5.08
7.4
Pde5aOLFOlfactory bulb20.53
22.76
Pde5aPPons5.09
5.7
Pde5aPALPallidum2.64
2.32
Pde5aRHPRetrohippocampal region12.86
10.6
Pde5asAMYStriatum-like amygdalar nuclei6.28
4.44
Pde5aSTRStriatum3.25
2.69
Pde5aSTRdStriatum dorsal region2.98
2.67
Pde5aSTRvStriatum ventral region2.76
1.89
Pde5aTHThalamus4.49
3.67
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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