AutismKB 2.0

Annotation Detail for TNKS


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Basic Information Top
Gene Symbol:TNKS ( PARP-5a,PARP5A,PARPL,TIN1,TINF1,TNKS1,pART5 )
Gene Full Name: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
Band: 8p23.1
Quick LinksEntrez ID:8658; OMIM: 603303; Uniprot ID:TNKS1_HUMAN; ENSEMBL ID: ENSG00000173273; HGNC ID: 11941
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst6 / 6231996
fetus64 / 564012113
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult110 / 193912156
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor1 / 3436629
chondrosarcoma4 / 8282348
colorectal tumor2 / 11424617
esophageal tumor1 / 1729057
gastrointestinal tumor1 / 1193698
germ cell tumor18 / 26384568
glioma7 / 10688365
head and neck tumor2 / 13630214
kidney tumor5 / 6895972
leukemia2 / 9584220
liver tumor3 / 9635931
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia6 / 9725061
normal259 / 336030777
ovarian tumor4 / 7668252
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer8 / 10268077
retinoblastoma0 / 463560 
skin tumor4 / 12494932
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites1 / 4001524
bladder2 / 2975767
blood1 / 1234788
bone3 / 7165541
bone marrow3 / 4880161
brain78 / 110098970
cervix1 / 4817120
connective tissue4 / 14925526
ear1 / 1621261
embryonic tissue19 / 21572288
esophagus1 / 2020949
eye12 / 21105456
heart3 / 8962633
intestine4 / 23447217
kidney11 / 21177751
larynx1 / 2414541
liver5 / 20774324
lung11 / 33697432
lymph1 / 4427022
lymph node9 / 9161098
mammary gland6 / 15327139
mouth1 / 6705214
muscle3 / 10771527
nerve1 / 1576863
ovary4 / 10205139
pancreas14 / 21481265
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland5 / 16585301
placenta11 / 28082539
prostate16 / 18934584
salivary gland0 / 201550 
skin13 / 21057461
spleen1 / 5395218
stomach0 / 966190 
testis52 / 330442157
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus4 / 23287817
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 216695_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.35
Adipocyte6.55
AdrenalCortex8.2
Adrenalgland6
Amygdala6.6
Appendix7.75
AtrioventricularNode7.6
BDCA4+_DentriticCells6.4
Bonemarrow7.2
BronchialEpithelialCells6.35
CD105+_Endothelial6.5
CD14+_Monocytes7
CD19+_BCells(neg._sel.)6.8
CD33+_Myeloid8.05
CD34+7.95
CD4+_Tcells6.75
CD56+_NKCells8.45
CD71+_EarlyErythroid6.4
CD8+_Tcells5.85
CardiacMyocytes15.95
Caudatenucleus6
Cerebellum5.55
CerebellumPeduncles8.1
CiliaryGanglion5.8
CingulateCortex7.1
Colorectaladenocarcinoma6.6
DorsalRootGanglion6.2
FetalThyroid6.65
Fetalbrain6.35
Fetalliver6
Fetallung5.05
GlobusPallidus5.4
Heart12.35
Hypothalamus6.95
Kidney6
Leukemia_chronicMyelogenousK-5626
Leukemia_promyelocytic-HL-605.95
Leukemialymphoblastic(MOLT-4)5.2
Liver10
Lung7.3
Lymphnode5.5
Lymphoma_burkitts(Daudi)8.8
Lymphoma_burkitts(Raji)10.2
MedullaOblongata6.05
OccipitalLobe5.95
OlfactoryBulb5.15
Ovary6.7
Pancreas5.6
PancreaticIslet7.25
ParietalLobe7.7
Pituitary7.75
Placenta6.7
Pons6.75
PrefrontalCortex7.85
Prostate7.6
Salivarygland5.7
SkeletalMuscle9.75
Skin7.6
SmoothMuscle7.55
Spinalcord7.15
SubthalamicNucleus6.35
SuperiorCervicalGanglion10
TemporalLobe6.8
Testis5.7
TestisGermCell5.45
TestisIntersitial6.05
TestisLeydigCell7.05
TestisSeminiferousTubule5.7
Thalamus6.95
Thymus4.95
Thyroid7.95
Tongue7.25
Tonsil6.85
Trachea5.55
TrigeminalGanglion7.8
Uterus5.3
UterusCorpus6.9
WholeBlood7.25
Wholebrain5.3
colon6.65
pineal_day8.08
pineal_night7.94
retina8.05
small_intestine6.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P20927
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.33 ± 0.34
Basal Forebrain6.38 ± 0.15
Basal Part of Pons6.46 ± 0.25
Cerebellar Cortex6.5 ± 0.27
Cerebellar Nuclei6.72 ± 0.28
Claustrum6.43 ± 0.55
Epithalamus6.2 ± 0.37
Frontal Lobe6.35 ± 0.34
Globus Pallidus6.68 ± 0.36
Hypothalamus6.54 ± 0.31
Insula6.26 ± 0.29
Limbic Lobe6.33 ± 0.34
Mesencephalon6.49 ± 0.32
Myelencephalon6.34 ± 0.34
Occipital Lobe6.49 ± 0.25
Parietal Lobe6.41 ± 0.37
Pontine Tegmentum6.39 ± 0.45
Striatum6.35 ± 0.36
Subthalamus6.64 ± 0.15
Temporal Lobe6.26 ± 0.33
Thalamus6.61 ± 0.29
White Matter7.67 ± 0.14
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
TnksCBCerebellum9.75
10.18
TnksCTXCerebral cortex2.26
1.97
TnksHIPHippocampal region13.54
14.1
TnksHPFHippocampal formation11.18
10.62
TnksHYHypothalamus3.32
2.94
TnksLSXLateral septal complex0.8
0.89
TnksMBMidbrain6.98
7
TnksMYMedulla14.92
17.01
TnksOLFOlfactory bulb14.23
12.31
TnksPPons11.32
12.15
TnksPALPallidum4.14
4.09
TnksRHPRetrohippocampal region6.75
5.47
TnkssAMYStriatum-like amygdalar nuclei4.77
3.96
TnksSTRStriatum1.2
1.16
TnksSTRdStriatum dorsal region0.7
0.79
TnksSTRvStriatum ventral region1.05
0.87
TnksTHThalamus6.5
7.15
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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