AutismKB 2.0

Annotation Detail for EIF3A


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Basic Information Top
Gene Symbol:EIF3A ( EIF3,EIF3S10,KIAA0139,P167,TIF32,eIF3-p170,eIF3-theta,p180,p185 )
Gene Full Name: eukaryotic translation initiation factor 3, subunit A
Band: 10q26.11
Quick LinksEntrez ID:8661; OMIM: 602039; Uniprot ID:EIF3A_HUMAN; ENSEMBL ID: ENSG00000107581; HGNC ID: 3271
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body31 / 70761438
blastocyst32 / 62319513
fetus105 / 564012186
neonate4 / 31097128
infant3 / 23620127
juvenile19 / 55556341
adult324 / 1939121167
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor5 / 12794390
bladder carcinoma2 / 17475114
breast (mammary gland) tumor15 / 94178159
cervical tumor5 / 34366145
chondrosarcoma8 / 8282396
colorectal tumor28 / 114246245
esophageal tumor6 / 17290347
gastrointestinal tumor19 / 119369159
germ cell tumor40 / 263845151
glioma7 / 10688365
head and neck tumor38 / 136302278
kidney tumor5 / 6895972
leukemia21 / 95842219
liver tumor37 / 96359383
lung tumor7 / 10312767
lymphoma12 / 71755167
non-neoplasia11 / 97250113
normal565 / 3360307168
ovarian tumor12 / 76682156
pancreatic tumor11 / 104616105
primitive neuroectodermal tumor of the CNS8 / 12568063
prostate cancer11 / 102680107
retinoblastoma17 / 46356366
skin tumor14 / 124949112
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor14 / 90257155
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland6 / 33197180
ascites4 / 4001599
bladder3 / 29757100
blood19 / 123478153
bone15 / 71655209
bone marrow7 / 48801143
brain112 / 1100989101
cervix5 / 48171103
connective tissue12 / 14925580
ear6 / 16212370
embryonic tissue81 / 215722375
esophagus6 / 20209296
eye40 / 211054189
heart18 / 89626200
intestine51 / 234472217
kidney32 / 211777151
larynx7 / 24145289
liver65 / 207743312
lung51 / 336974151
lymph10 / 44270225
lymph node18 / 91610196
mammary gland32 / 153271208
mouth13 / 67052193
muscle19 / 107715176
nerve3 / 15768190
ovary13 / 102051127
pancreas27 / 214812125
parathyroid1 / 2053948
pharynx4 / 4132896
pituitary gland1 / 1658560
placenta33 / 280825117
prostate13 / 18934568
salivary gland2 / 2015599
skin28 / 210574132
spleen6 / 53952111
stomach21 / 96619217
testis60 / 330442181
thymus11 / 81131135
thyroid22 / 47473463
tonsil1 / 1699958
trachea11 / 52413209
umbilical cord3 / 13680219
uterus34 / 232878145
vascular13 / 51780251
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 200595_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts681.2
Adipocyte281.05
AdrenalCortex67.05
Adrenalgland34.15
Amygdala265.7
Appendix38
AtrioventricularNode15.2
BDCA4+_DentriticCells377.1
Bonemarrow15.7
BronchialEpithelialCells457.9
CD105+_Endothelial735.1
CD14+_Monocytes314.2
CD19+_BCells(neg._sel.)252.55
CD33+_Myeloid563.55
CD34+766.75
CD4+_Tcells218.3
CD56+_NKCells337.85
CD71+_EarlyErythroid170.6
CD8+_Tcells260.1
CardiacMyocytes158.15
Caudatenucleus64.5
Cerebellum21.65
CerebellumPeduncles36.45
CiliaryGanglion33.9
CingulateCortex38.85
Colorectaladenocarcinoma445.05
DorsalRootGanglion19.35
FetalThyroid49.7
Fetalbrain161.6
Fetalliver206.25
Fetallung225.7
GlobusPallidus24.05
Heart28.3
Hypothalamus110.2
Kidney16.05
Leukemia_chronicMyelogenousK-562339.85
Leukemia_promyelocytic-HL-60596.7
Leukemialymphoblastic(MOLT-4)221.75
Liver16.75
Lung47.35
Lymphnode186.15
Lymphoma_burkitts(Daudi)332.65
Lymphoma_burkitts(Raji)734.45
MedullaOblongata61.3
OccipitalLobe95.4
OlfactoryBulb44.05
Ovary27.8
Pancreas169.7
PancreaticIslet278.2
ParietalLobe42.95
Pituitary169.85
Placenta88.05
Pons29
PrefrontalCortex195.65
Prostate137.9
Salivarygland119.85
SkeletalMuscle22.2
Skin55.55
SmoothMuscle424.8
Spinalcord164.75
SubthalamicNucleus26.45
SuperiorCervicalGanglion29.65
TemporalLobe36.65
Testis26.9
TestisGermCell107.4
TestisIntersitial27.4
TestisLeydigCell49.05
TestisSeminiferousTubule31.45
Thalamus68.7
Thymus133.15
Thyroid620.55
Tongue75.45
Tonsil152.4
Trachea94.65
TrigeminalGanglion18.4
Uterus296.25
UterusCorpus30.3
WholeBlood358.3
Wholebrain44.75
colon215.85
pineal_day82.84
pineal_night118.56
retina100.9
small_intestine163.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P86550
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala10.37 ± 0.29
Basal Forebrain10.67 ± 0.1
Basal Part of Pons10.8 ± 0.23
Cerebellar Cortex10.73 ± 0.21
Cerebellar Nuclei10.69 ± 0.17
Claustrum10.34 ± 0.41
Epithalamus11.13 ± 0.3
Frontal Lobe10.76 ± 0.25
Globus Pallidus11.21 ± 0.29
Hypothalamus10.83 ± 0.25
Insula10.8 ± 0.24
Limbic Lobe10.49 ± 0.28
Mesencephalon10.7 ± 0.25
Myelencephalon10.66 ± 0.28
Occipital Lobe10.6 ± 0.35
Parietal Lobe10.68 ± 0.28
Pontine Tegmentum10.68 ± 0.26
Striatum10.6 ± 0.27
Subthalamus10.99 ± 0.07
Temporal Lobe10.69 ± 0.2
Thalamus10.72 ± 0.25
White Matter11.36 ± 0.27
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Eif3s10CBCerebellum43.51
87.5
Eif3s10CTXCerebral cortex100
100
Eif3s10HIPHippocampal region100
100
Eif3s10HPFHippocampal formation100
100
Eif3s10HYHypothalamus100
100
Eif3s10LSXLateral septal complex100
100
Eif3s10MBMidbrain99.62
100
Eif3s10MYMedulla100
100
Eif3s10OLFOlfactory bulb100
100
Eif3s10PPons95.02
100
Eif3s10PALPallidum100
100
Eif3s10RHPRetrohippocampal region100
100
Eif3s10sAMYStriatum-like amygdalar nuclei100
100
Eif3s10STRStriatum100
100
Eif3s10STRdStriatum dorsal region100
100
Eif3s10STRvStriatum ventral region100
100
Eif3s10THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
EIF3A_HUMAN_0 0 0 0 FNVLQYVVPEVK PRIDE
EIF3A_HUMAN_0 0 0 0 LLDMDGIIVEK PRIDE
EIF3A_HUMAN_0 0 0 0 LTSLVPFVDAFQLER PRIDE
EIF3A_HUMAN_0 0 0 0 NICQQVNIK PRIDE
EIF3A_HUMAN_0 0 0 0 RGPEEDRFSR PRIDE
EIF3A_HUMAN_0 0 0 0 SGNALFHASTLHR PRIDE
EIF3A_HUMAN_0 0 0 0 TLSFGSDLNYATR PRIDE
EIF3A_HUMAN_0 0 0 0 VLLATLSIPITPER PRIDE
EIF3A_HUMAN_1110 11 1110 1120 RGLDDDRGPWR PRIDE
EIF3A_HUMAN_1367 15 1367 1381 TKNETDEDGWTTVRR PRIDE
EIF3A_HUMAN_172 11 172 182 LYHDIAQQAFK PRIDE
EIF3A_HUMAN_2 13 2 14 PAYFQRPENALKR PRIDE
EIF3A_HUMAN_203 8 203 210 MHLSQIQR PRIDE
EIF3A_HUMAN_210 23 210 232 HHNQSTAINLNNPESQSMHLETR PRIDE
EIF3A_HUMAN_24 12 24 35 QPALDVLYDVMK PRIDE
EIF3A_HUMAN_265 14 265 278 KPPKPQLMANYYNK PRIDE
EIF3A_HUMAN_285 13 285 297 SGNALFHASTLHR PRIDE
EIF3A_HUMAN_321 14 321 334 VLLATLSIPITPER PRIDE
EIF3A_HUMAN_321 19 321 339 VLLATLSIPITPERTDIAR PRIDE
EIF3A_HUMAN_340 11 340 350 LLDMDGIIVEK PRIDE
EIF3A_HUMAN_341 11 341 351 LLDMDGIIVEK PRIDE
EIF3A_HUMAN_353 14 353 366 RLATLLGLQAPPTR PRIDE
EIF3A_HUMAN_354 13 354 366 LATLLGLQAPPTR PRIDE
EIF3A_HUMAN_367 9 367 375 IGLINDMVR PRIDE
EIF3A_HUMAN_368 9 368 376 IGLINDMVR PRIDE
EIF3A_HUMAN_376 12 376 387 FNVLQYVVPEVK PRIDE
EIF3A_HUMAN_377 12 377 388 FNVLQYVVPEVK PRIDE
EIF3A_HUMAN_388 14 388 401 DLYNWLEVEFNPLK PRIDE
EIF3A_HUMAN_438 16 438 453 LLQQVSQIYQSIEFSR PRIDE
EIF3A_HUMAN_454 15 454 468 LTSLVPFVDAFQLER PRIDE
EIF3A_HUMAN_489 13 489 501 TLSFGSDLNYATR PRIDE
EIF3A_HUMAN_502 18 502 519 EDAPIGPHLQSMPSEQIR PRIDE
EIF3A_HUMAN_520 12 520 531 NQLTAMSSVLAK PRIDE
EIF3A_HUMAN_532 27 532 558 ALEVIKPAHILQEKEEQHQLAVTAYLK PRIDE
EIF3A_HUMAN_6 9 6 14 QRPENALKR PRIDE
EIF3A_HUMAN_651 21 651 671 AFKDIDIEDLEELDPDFIMAK PRIDE
EIF3A_HUMAN_673 15 673 687 QVEQLEKEKKELQER PRIDE
EIF3A_HUMAN_702 9 702 710 RLEEIPLIK PRIDE
EIF3A_HUMAN_718 14 718 731 IKDMDLWEQQEEER PRIDE
EIF3A_HUMAN_719 14 719 732 IKDMDLWEQQEEER PRIDE
EIF3A_HUMAN_75 9 75 83 NICQQVNIK PRIDE
EIF3A_HUMAN_752 11 752 762 MLEDRDLFVMR PRIDE
EIF3A_HUMAN_769 14 769 782 QSVYEEKLKQFEER PRIDE
EIF3A_HUMAN_817 8 817 824 RAEEQMLK PRIDE
EIF3A_HUMAN_860 9 860 868 QRELEIEER PRIDE
EIF3A_HUMAN_960 10 960 969 RGMDDDRGPR PRIDE
PAp00003236 7 477 483 HCDLQVR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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