AutismKB 2.0

Annotation Detail for EIF3B


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Basic Information Top
Gene Symbol:EIF3B ( EIF3-ETA,EIF3-P110,EIF3-P116,EIF3S9,MGC104664,MGC131875,PRT1 )
Gene Full Name: eukaryotic translation initiation factor 3, subunit B
Band: 7p22.3
Quick LinksEntrez ID:8662; OMIM: 603917; Uniprot ID:EIF3B_HUMAN; ENSEMBL ID: ENSG00000106263; HGNC ID: 3280
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body8 / 70761113
blastocyst18 / 62319288
fetus31 / 56401254
neonate4 / 31097128
infant0 / 236200 
juvenile12 / 55556215
adult334 / 1939121172
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma4 / 17475228
breast (mammary gland) tumor32 / 94178339
cervical tumor11 / 34366320
chondrosarcoma19 / 82823229
colorectal tumor59 / 114246516
esophageal tumor5 / 17290289
gastrointestinal tumor19 / 119369159
germ cell tumor55 / 263845208
glioma26 / 106883243
head and neck tumor48 / 136302352
kidney tumor18 / 68959261
leukemia6 / 9584262
liver tumor22 / 96359228
lung tumor29 / 103127281
lymphoma24 / 71755334
non-neoplasia5 / 9725051
normal310 / 336030792
ovarian tumor13 / 76682169
pancreatic tumor43 / 104616411
primitive neuroectodermal tumor of the CNS30 / 125680238
prostate cancer22 / 102680214
retinoblastoma10 / 46356215
skin tumor47 / 124949376
soft tissue/muscle tissue tumor21 / 125191167
uterine tumor22 / 90257243
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites8 / 40015199
bladder4 / 29757134
blood18 / 123478145
bone18 / 71655251
bone marrow2 / 4880140
brain92 / 110098983
cervix14 / 48171290
connective tissue10 / 14925566
ear0 / 162120 
embryonic tissue36 / 215722166
esophagus5 / 20209247
eye34 / 211054161
heart6 / 8962666
intestine80 / 234472341
kidney34 / 211777160
larynx13 / 24145538
liver32 / 207743154
lung55 / 336974163
lymph21 / 44270474
lymph node7 / 9161076
mammary gland42 / 153271274
mouth23 / 67052343
muscle2 / 10771518
nerve5 / 15768317
ovary22 / 102051215
pancreas46 / 214812214
parathyroid0 / 205390 
pharynx6 / 41328145
pituitary gland0 / 165850 
placenta37 / 280825131
prostate42 / 189345221
salivary gland6 / 20155297
skin59 / 210574280
spleen5 / 5395292
stomach12 / 96619124
testis50 / 330442151
thymus8 / 8113198
thyroid5 / 47473105
tonsil4 / 16999235
trachea1 / 5241319
umbilical cord2 / 13680146
uterus53 / 232878227
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211501_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts364.95
Adipocyte51.05
AdrenalCortex77.15
Adrenalgland46.55
Amygdala53.9
Appendix47.85
AtrioventricularNode52.2
BDCA4+_DentriticCells258.7
Bonemarrow78.5
BronchialEpithelialCells281.7
CD105+_Endothelial280.75
CD14+_Monocytes207.85
CD19+_BCells(neg._sel.)119.25
CD33+_Myeloid168.35
CD34+348.1
CD4+_Tcells181.95
CD56+_NKCells177.2
CD71+_EarlyErythroid161.65
CD8+_Tcells147.55
CardiacMyocytes142
Caudatenucleus45.15
Cerebellum39.35
CerebellumPeduncles57.4
CiliaryGanglion46.65
CingulateCortex48.4
Colorectaladenocarcinoma424.65
DorsalRootGanglion44.15
FetalThyroid73.55
Fetalbrain48.9
Fetalliver46.3
Fetallung78.8
GlobusPallidus39.9
Heart46.1
Hypothalamus58.4
Kidney40.4
Leukemia_chronicMyelogenousK-562346.25
Leukemia_promyelocytic-HL-60214.9
Leukemialymphoblastic(MOLT-4)51.5
Liver91.1
Lung174.8
Lymphnode50.3
Lymphoma_burkitts(Daudi)338.05
Lymphoma_burkitts(Raji)688.3
MedullaOblongata34.6
OccipitalLobe45.35
OlfactoryBulb32.55
Ovary38.75
Pancreas61.1
PancreaticIslet62.85
ParietalLobe47.95
Pituitary63.25
Placenta72.2
Pons42.05
PrefrontalCortex59.75
Prostate212.05
Salivarygland43.5
SkeletalMuscle77.25
Skin46.85
SmoothMuscle307.7
Spinalcord54
SubthalamicNucleus49.6
SuperiorCervicalGanglion51.15
TemporalLobe44.5
Testis122.95
TestisGermCell154.25
TestisIntersitial89.9
TestisLeydigCell67.35
TestisSeminiferousTubule118.3
Thalamus53.85
Thymus133.7
Thyroid138.4
Tongue61.95
Tonsil81.2
Trachea40.05
TrigeminalGanglion62.1
Uterus91.9
UterusCorpus43.6
WholeBlood61.1
Wholebrain47.95
colon92.1
pineal_day60.18
pineal_night55
retina59.7
small_intestine91.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P10589
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.96 ± 0.56
Basal Forebrain4.9 ± 0.49
Basal Part of Pons4.52 ± 0.61
Cerebellar Cortex4.63 ± 0.66
Cerebellar Nuclei4.55 ± 0.49
Claustrum5.16 ± 0.79
Epithalamus4.08 ± 0.28
Frontal Lobe4.65 ± 0.67
Globus Pallidus5.14 ± 0.64
Hypothalamus4.35 ± 0.54
Insula4.33 ± 0.98
Limbic Lobe4.97 ± 0.68
Mesencephalon4.64 ± 0.7
Myelencephalon4.82 ± 0.68
Occipital Lobe4.89 ± 0.63
Parietal Lobe4.71 ± 0.64
Pontine Tegmentum4.61 ± 0.68
Striatum4.75 ± 0.65
Subthalamus4.15 ± 0.64
Temporal Lobe4.73 ± 0.77
Thalamus4.64 ± 0.61
White Matter5.32 ± 0.58
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Eif3s9CBCerebellum12.78
17.71
Eif3s9CTXCerebral cortex54.24
44.08
Eif3s9HIPHippocampal region45.07
61.89
Eif3s9HPFHippocampal formation49.58
57.36
Eif3s9HYHypothalamus25.73
22.03
Eif3s9LSXLateral septal complex6.37
4.94
Eif3s9MBMidbrain16.04
15.94
Eif3s9MYMedulla22.52
34.92
Eif3s9OLFOlfactory bulb49.43
46.71
Eif3s9PPons25.77
33.15
Eif3s9PALPallidum26.99
26.21
Eif3s9RHPRetrohippocampal region60.13
52.88
Eif3s9sAMYStriatum-like amygdalar nuclei58.59
47.26
Eif3s9STRStriatum36.96
28.57
Eif3s9STRdStriatum dorsal region35.9
27.35
Eif3s9STRvStriatum ventral region42.3
32.3
Eif3s9THThalamus19.47
16.7
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
EIF3B_HUMAN_1 16 1 16 MQDAENVAVPEAAEER PRIDE
EIF3B_HUMAN_121 14 121 134 AQAVSEDAGGNEGR PRIDE
EIF3B_HUMAN_2 15 2 16 QDAENVAVPEAAEER PRIDE
EIF3B_HUMAN_230 18 230 247 GYIFLEYASPAHAVDAVK PRIDE
EIF3B_HUMAN_315 17 315 331 TSIFWNDVKDPVSIEER PRIDE
EIF3B_HUMAN_37 31 37 67 PAGPGAPEAAGTEASSEEVGIAEAGPEPEVR PRIDE
EIF3B_HUMAN_440 20 440 459 MTLDTLSIYETPSMGLLDKK PRIDE
EIF3B_HUMAN_463 29 463 491 ISGIKDFSWSPGGNIIAFWVPEDKDIPAR PRIDE
EIF3B_HUMAN_493 9 493 501 VTLMQLPTR PRIDE
EIF3B_HUMAN_535 13 535 547 GTQGVVTNFEIFR PRIDE
EIF3B_HUMAN_553 10 553 562 QVPVDVVEMK PRIDE
EIF3B_HUMAN_7 10 7 16 VAVPEAAEER PRIDE
EIF3B_HUMAN_763 10 763 772 MAQELYMEQK PRIDE
PAp00002578 16 371 386 FSHQGVQLIDFSPCER Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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