AutismKB 2.0

Annotation Detail for EIF3C


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Basic Information Top
Gene Symbol:EIF3C ( EIF3CL,EIF3S8,FLJ78287,MGC189744,eIF3-p110 )
Gene Full Name: eukaryotic translation initiation factor 3, subunit C
Band: 16p11.2
Quick LinksEntrez ID:8663; OMIM: 603916; Uniprot ID:EIF3C_HUMAN; ENSEMBL ID: ENSG00000184110; HGNC ID: 3279
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body30 / 70761423
blastocyst42 / 62319673
fetus229 / 564012406
neonate32 / 310971029
infant5 / 23620211
juvenile62 / 555561115
adult406 / 1939121209
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor33 / 94178350
cervical tumor17 / 34366494
chondrosarcoma31 / 82823374
colorectal tumor66 / 114246577
esophageal tumor1 / 1729057
gastrointestinal tumor41 / 119369343
germ cell tumor190 / 263845720
glioma31 / 106883290
head and neck tumor86 / 136302630
kidney tumor32 / 68959464
leukemia24 / 95842250
liver tumor50 / 96359518
lung tumor69 / 103127669
lymphoma63 / 71755877
non-neoplasia37 / 97250380
normal1061 / 3360307315
ovarian tumor19 / 76682247
pancreatic tumor73 / 104616697
primitive neuroectodermal tumor of the CNS86 / 125680684
prostate cancer15 / 102680146
retinoblastoma49 / 463561057
skin tumor136 / 1249491088
soft tissue/muscle tissue tumor69 / 125191551
uterine tumor23 / 90257254
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland9 / 33197271
ascites14 / 40015349
bladder7 / 29757235
blood50 / 123478404
bone17 / 71655237
bone marrow12 / 48801245
brain570 / 1100989517
cervix18 / 48171373
connective tissue57 / 149255381
ear0 / 162120 
embryonic tissue95 / 215722440
esophagus5 / 20209247
eye82 / 211054388
heart17 / 89626189
intestine95 / 234472405
kidney80 / 211777377
larynx0 / 241450 
liver56 / 207743269
lung114 / 336974338
lymph60 / 442701355
lymph node4 / 9161043
mammary gland36 / 153271234
mouth79 / 670521178
muscle55 / 107715510
nerve4 / 15768253
ovary31 / 102051303
pancreas78 / 214812363
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta89 / 280825316
prostate45 / 189345237
salivary gland3 / 20155148
skin167 / 210574793
spleen33 / 53952611
stomach23 / 96619238
testis193 / 330442584
thymus139 / 811311713
thyroid18 / 47473379
tonsil3 / 16999176
trachea24 / 52413457
umbilical cord20 / 136801461
uterus77 / 232878330
vascular19 / 51780366
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 200647_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts2278.15
Adipocyte628.85
AdrenalCortex335.15
Adrenalgland403.8
Amygdala923.3
Appendix265.5
AtrioventricularNode67.25
BDCA4+_DentriticCells1026.6
Bonemarrow488.5
BronchialEpithelialCells1170.8
CD105+_Endothelial908.3
CD14+_Monocytes926.75
CD19+_BCells(neg._sel.)808.75
CD33+_Myeloid744.6
CD34+1249.8
CD4+_Tcells765.65
CD56+_NKCells725.75
CD71+_EarlyErythroid935.25
CD8+_Tcells617.35
CardiacMyocytes740.45
Caudatenucleus403.65
Cerebellum287.6
CerebellumPeduncles334.95
CiliaryGanglion103.35
CingulateCortex404.7
Colorectaladenocarcinoma1691.85
DorsalRootGanglion137.85
FetalThyroid807.3
Fetalbrain782.6
Fetalliver345.95
Fetallung691.85
GlobusPallidus235.55
Heart686.75
Hypothalamus577.3
Kidney570.85
Leukemia_chronicMyelogenousK-562982.05
Leukemia_promyelocytic-HL-60941.1
Leukemialymphoblastic(MOLT-4)821.85
Liver877.8
Lung1951.5
Lymphnode425.2
Lymphoma_burkitts(Daudi)876.15
Lymphoma_burkitts(Raji)1326.1
MedullaOblongata370.6
OccipitalLobe398.15
OlfactoryBulb256.15
Ovary367.95
Pancreas396.4
PancreaticIslet911.65
ParietalLobe476.95
Pituitary634.8
Placenta491.6
Pons257.75
PrefrontalCortex1148.75
Prostate1909.05
Salivarygland356.8
SkeletalMuscle360.25
Skin254.4
SmoothMuscle637.15
Spinalcord404.75
SubthalamicNucleus391.35
SuperiorCervicalGanglion156.25
TemporalLobe306.8
Testis1061.8
TestisGermCell1455.1
TestisIntersitial265.5
TestisLeydigCell428.35
TestisSeminiferousTubule596.35
Thalamus604.55
Thymus736.75
Thyroid1600
Tongue328.6
Tonsil374.4
Trachea403.7
TrigeminalGanglion98
Uterus928.75
UterusCorpus236
WholeBlood366.25
Wholebrain827.1
colon678.1
pineal_day722
pineal_night592.42
retina631.45
small_intestine579.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P77572
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.65 ± 0.24
Basal Forebrain9.4 ± 0.12
Basal Part of Pons9.74 ± 0.1
Cerebellar Cortex9.33 ± 0.18
Cerebellar Nuclei9.3 ± 0.14
Claustrum9.32 ± 0.26
Epithalamus9.38 ± 0.27
Frontal Lobe9.59 ± 0.25
Globus Pallidus9.27 ± 0.34
Hypothalamus9.54 ± 0.22
Insula9.68 ± 0.22
Limbic Lobe9.66 ± 0.3
Mesencephalon9.44 ± 0.27
Myelencephalon9.45 ± 0.31
Occipital Lobe9.2 ± 0.24
Parietal Lobe9.46 ± 0.27
Pontine Tegmentum9.45 ± 0.27
Striatum9.26 ± 0.35
Subthalamus9.37 ± 0.13
Temporal Lobe9.65 ± 0.27
Thalamus9.29 ± 0.18
White Matter9.03 ± 0.11
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Eif3s8CBCerebellum96.78
100
Eif3s8CTXCerebral cortex100
100
Eif3s8HIPHippocampal region100
100
Eif3s8HPFHippocampal formation100
100
Eif3s8HYHypothalamus100
100
Eif3s8LSXLateral septal complex100
100
Eif3s8MBMidbrain100
100
Eif3s8MYMedulla100
100
Eif3s8OLFOlfactory bulb100
100
Eif3s8PPons100
100
Eif3s8PALPallidum100
100
Eif3s8RHPRetrohippocampal region100
100
Eif3s8sAMYStriatum-like amygdalar nuclei100
100
Eif3s8STRStriatum100
100
Eif3s8STRdStriatum dorsal region100
100
Eif3s8STRvStriatum ventral region100
100
Eif3s8THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
EIF3C_HUMAN_532 19 532 550 SEQDQAENEGEDSAVLMER PRIDE
EIF3C_HUMAN_623 19 623 641 QGLTKDAHNALLDIQSSGR PRIDE
EIF3C_HUMAN_713 7 713 719 QFHHQLR PRIDE
EIF3C_HUMAN_724 11 724 734 QPLLGPPESMR PRIDE
EIF3C_HUMAN_825 22 825 846 MIINEELMASLDQPTQTVVMHR PRIDE
EIF3C_HUMAN_847 26 847 872 TEPTAQQNLALQLAEKLGSLVENNER PRIDE
EIF3C_HUMAN_894 7 894 900 KNEGYMR PRIDE
EIF3C_HUMAN_906 8 906 913 QQQSQTAY PRIDE
PAp00001134 10 79 88 CLEEFELLGK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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