AutismKB 2.0

Annotation Detail for BECN1


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Basic Information Top
Gene Symbol:BECN1 ( ATG6,VPS30,beclin1 )
Gene Full Name: beclin 1, autophagy related
Band: 17q21.31
Quick LinksEntrez ID:8678; OMIM: 604378; Uniprot ID:BECN1_HUMAN; ENSEMBL ID: ENSG00000126581; HGNC ID: 1034
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst4 / 6231964
fetus42 / 56401274
neonate0 / 310970 
infant3 / 23620127
juvenile10 / 55556179
adult186 / 193912195
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor7 / 9417874
cervical tumor8 / 34366232
chondrosarcoma3 / 8282336
colorectal tumor17 / 114246148
esophageal tumor1 / 1729057
gastrointestinal tumor8 / 11936967
germ cell tumor15 / 26384556
glioma4 / 10688337
head and neck tumor8 / 13630258
kidney tumor5 / 6895972
leukemia8 / 9584283
liver tumor26 / 96359269
lung tumor4 / 10312738
lymphoma10 / 71755139
non-neoplasia7 / 9725071
normal319 / 336030794
ovarian tumor8 / 76682104
pancreatic tumor9 / 10461686
primitive neuroectodermal tumor of the CNS13 / 125680103
prostate cancer10 / 10268097
retinoblastoma4 / 4635686
skin tumor9 / 12494972
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland4 / 33197120
ascites1 / 4001524
bladder3 / 29757100
blood9 / 12347872
bone3 / 7165541
bone marrow7 / 48801143
brain82 / 110098974
cervix8 / 48171166
connective tissue14 / 14925593
ear1 / 1621261
embryonic tissue9 / 21572241
esophagus1 / 2020949
eye19 / 21105490
heart17 / 89626189
intestine26 / 234472110
kidney14 / 21177766
larynx1 / 2414541
liver34 / 207743163
lung37 / 336974109
lymph3 / 4427067
lymph node12 / 91610130
mammary gland12 / 15327178
mouth1 / 6705214
muscle5 / 10771546
nerve1 / 1576863
ovary8 / 10205178
pancreas14 / 21481265
parathyroid3 / 20539146
pharynx2 / 4132848
pituitary gland2 / 16585120
placenta25 / 28082589
prostate26 / 189345137
salivary gland1 / 2015549
skin17 / 21057480
spleen9 / 53952166
stomach11 / 96619113
testis29 / 33044287
thymus5 / 8113161
thyroid6 / 47473126
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus26 / 232878111
vascular10 / 51780193
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208945_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts98.4
Adipocyte104.7
AdrenalCortex95.9
Adrenalgland76.7
Amygdala94.35
Appendix84.85
AtrioventricularNode104.55
BDCA4+_DentriticCells96.2
Bonemarrow98.75
BronchialEpithelialCells111.7
CD105+_Endothelial69.6
CD14+_Monocytes111.4
CD19+_BCells(neg._sel.)141.5
CD33+_Myeloid100.65
CD34+81.4
CD4+_Tcells144.45
CD56+_NKCells137.95
CD71+_EarlyErythroid70.85
CD8+_Tcells119.1
CardiacMyocytes103.25
Caudatenucleus82.75
Cerebellum69.75
CerebellumPeduncles114.85
CiliaryGanglion187.25
CingulateCortex90.65
Colorectaladenocarcinoma85.5
DorsalRootGanglion108.65
FetalThyroid88.95
Fetalbrain88.8
Fetalliver69.95
Fetallung61.95
GlobusPallidus73.15
Heart75.85
Hypothalamus92.3
Kidney78.65
Leukemia_chronicMyelogenousK-56278.25
Leukemia_promyelocytic-HL-6084.5
Leukemialymphoblastic(MOLT-4)87.25
Liver91.35
Lung92.1
Lymphnode78.1
Lymphoma_burkitts(Daudi)130.8
Lymphoma_burkitts(Raji)81.6
MedullaOblongata78.05
OccipitalLobe86.55
OlfactoryBulb68.55
Ovary73.7
Pancreas85.85
PancreaticIslet106.5
ParietalLobe96.85
Pituitary126.25
Placenta105.25
Pons85.75
PrefrontalCortex104.05
Prostate69.9
Salivarygland66.35
SkeletalMuscle110.15
Skin75.4
SmoothMuscle98.65
Spinalcord105.5
SubthalamicNucleus84.3
SuperiorCervicalGanglion105.05
TemporalLobe71.6
Testis69.15
TestisGermCell72.5
TestisIntersitial56
TestisLeydigCell90.8
TestisSeminiferousTubule88.75
Thalamus92.75
Thymus90.3
Thyroid130.6
Tongue85.3
Tonsil109.95
Trachea81.45
TrigeminalGanglion104.15
Uterus70.5
UterusCorpus76
WholeBlood122.4
Wholebrain75.05
colon99.35
pineal_day84.24
pineal_night74.22
retina114.5
small_intestine100.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P313597
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.12 ± 0.61
Basal Forebrain6.18 ± 0.26
Basal Part of Pons6.82 ± 0.34
Cerebellar Cortex6.31 ± 0.3
Cerebellar Nuclei6.26 ± 0.57
Claustrum6.15 ± 0.68
Epithalamus6.63 ± 0.59
Frontal Lobe6.65 ± 0.4
Globus Pallidus6.07 ± 0.29
Hypothalamus6.79 ± 0.33
Insula6.66 ± 0.32
Limbic Lobe6.14 ± 0.66
Mesencephalon6.34 ± 0.47
Myelencephalon6.33 ± 0.58
Occipital Lobe5.86 ± 0.64
Parietal Lobe6.49 ± 0.48
Pontine Tegmentum6.38 ± 0.5
Striatum5.87 ± 0.5
Subthalamus6.62 ± 0.37
Temporal Lobe6.63 ± 0.39
Thalamus6.43 ± 0.42
White Matter6.42 ± 0.1
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Becn1CBCerebellum37.89
65.78
Becn1CTXCerebral cortex100
100
Becn1HIPHippocampal region100
100
Becn1HPFHippocampal formation98.43
100
Becn1HYHypothalamus87.41
84.25
Becn1LSXLateral septal complex100
97.08
Becn1MBMidbrain72.38
78.96
Becn1MYMedulla62.28
85.17
Becn1OLFOlfactory bulb89.56
97.41
Becn1PPons60.64
78.95
Becn1PALPallidum86.49
95.81
Becn1RHPRetrohippocampal region95.05
94.03
Becn1sAMYStriatum-like amygdalar nuclei100
99.35
Becn1STRStriatum92.71
79.08
Becn1STRdStriatum dorsal region84
70.39
Becn1STRvStriatum ventral region100
89.87
Becn1THThalamus99.11
100
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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