AutismKB 2.0

Annotation Detail for CDC23


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Basic Information Top
Gene Symbol:CDC23 ( ANAPC8,APC8 )
Gene Full Name: cell division cycle 23 homolog (S. cerevisiae)
Band: 5q31.2
Quick LinksEntrez ID:8697; OMIM: 603462; Uniprot ID:CDC23_HUMAN; ENSEMBL ID: ENSG00000094880; HGNC ID: 1724
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst9 / 62319144
fetus43 / 56401276
neonate3 / 3109796
infant1 / 2362042
juvenile2 / 5555635
adult121 / 193912162
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma7 / 17475400
breast (mammary gland) tumor4 / 9417842
cervical tumor2 / 3436658
chondrosarcoma4 / 8282348
colorectal tumor1 / 1142468
esophageal tumor1 / 1729057
gastrointestinal tumor3 / 11936925
germ cell tumor34 / 263845128
glioma5 / 10688346
head and neck tumor8 / 13630258
kidney tumor3 / 6895943
leukemia3 / 9584231
liver tumor0 / 963590 
lung tumor3 / 10312729
lymphoma1 / 7175513
non-neoplasia7 / 9725071
normal223 / 336030766
ovarian tumor7 / 7668291
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS10 / 12568079
prostate cancer3 / 10268029
retinoblastoma1 / 4635621
skin tumor9 / 12494972
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites0 / 400150 
bladder8 / 29757268
blood4 / 12347832
bone4 / 7165555
bone marrow2 / 4880140
brain78 / 110098970
cervix6 / 48171124
connective tissue7 / 14925546
ear2 / 16212123
embryonic tissue23 / 215722106
esophagus1 / 2020949
eye4 / 21105418
heart1 / 8962611
intestine8 / 23447234
kidney12 / 21177756
larynx0 / 241450 
liver5 / 20774324
lung14 / 33697441
lymph1 / 4427022
lymph node1 / 9161010
mammary gland6 / 15327139
mouth8 / 67052119
muscle13 / 107715120
nerve2 / 15768126
ovary8 / 10205178
pancreas11 / 21481251
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta27 / 28082596
prostate5 / 18934526
salivary gland3 / 20155148
skin15 / 21057471
spleen5 / 5395292
stomach2 / 9661920
testis48 / 330442145
thymus16 / 81131197
thyroid4 / 4747384
tonsil0 / 169990 
trachea5 / 5241395
umbilical cord0 / 136800 
uterus14 / 23287860
vascular6 / 51780115
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202892_at
Cell line Expression level Expression bar
721_B_lymphoblasts129.8
Adipocyte9.25
AdrenalCortex8.15
Adrenalgland4.7
Amygdala12.95
Appendix18.4
AtrioventricularNode7.7
BDCA4+_DentriticCells37.65
Bonemarrow9.2
BronchialEpithelialCells40.95
CD105+_Endothelial69.05
CD14+_Monocytes15.15
CD19+_BCells(neg._sel.)11.6
CD33+_Myeloid20.45
CD34+65
CD4+_Tcells32.45
CD56+_NKCells22.25
CD71+_EarlyErythroid19.35
CD8+_Tcells33.8
CardiacMyocytes15.95
Caudatenucleus7.5
Cerebellum6.7
CerebellumPeduncles9.6
CiliaryGanglion8.75
CingulateCortex8
Colorectaladenocarcinoma14.05
DorsalRootGanglion8.05
FetalThyroid8.9
Fetalbrain10.1
Fetalliver11.9
Fetallung10.5
GlobusPallidus7.45
Heart11.8
Hypothalamus10.7
Kidney7.2
Leukemia_chronicMyelogenousK-56233.6
Leukemia_promyelocytic-HL-6021.05
Leukemialymphoblastic(MOLT-4)25.4
Liver11.45
Lung10.3
Lymphnode8.75
Lymphoma_burkitts(Daudi)17.3
Lymphoma_burkitts(Raji)18.55
MedullaOblongata9.3
OccipitalLobe8.4
OlfactoryBulb8
Ovary6.15
Pancreas6.1
PancreaticIslet11.7
ParietalLobe8.9
Pituitary10.25
Placenta18.75
Pons10.85
PrefrontalCortex11.2
Prostate12.4
Salivarygland8.2
SkeletalMuscle8.35
Skin13
SmoothMuscle17.1
Spinalcord8.05
SubthalamicNucleus8.05
SuperiorCervicalGanglion12.2
TemporalLobe9.15
Testis8.75
TestisGermCell18.9
TestisIntersitial7.2
TestisLeydigCell10.05
TestisSeminiferousTubule8.45
Thalamus7.95
Thymus9.25
Thyroid16.6
Tongue9.25
Tonsil9.55
Trachea7.55
TrigeminalGanglion10.7
Uterus13.5
UterusCorpus6.65
WholeBlood10.95
Wholebrain6.25
colon26.5
pineal_day16.14
pineal_night14.52
retina15.025
small_intestine26.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_5579_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.45 ± 0.9
Basal Forebrain3.04 ± 0.54
Basal Part of Pons2.64 ± 0.78
Cerebellar Cortex3.49 ± 0.46
Cerebellar Nuclei3.36 ± 0.7
Claustrum3.43 ± 0.86
Epithalamus2.61 ± 0.98
Frontal Lobe2.64 ± 0.66
Globus Pallidus2.63 ± 0.86
Hypothalamus2.78 ± 0.91
Insula2.75 ± 0.78
Limbic Lobe2.91 ± 0.62
Mesencephalon2.95 ± 0.7
Myelencephalon2.93 ± 0.67
Occipital Lobe3.39 ± 0.65
Parietal Lobe2.92 ± 0.83
Pontine Tegmentum3.02 ± 0.78
Striatum2.93 ± 0.71
Subthalamus3.28 ± 0.47
Temporal Lobe2.83 ± 0.78
Thalamus2.9 ± 0.67
White Matter3.22 ± 0.89
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Cdc23CBCerebellum31.55
35.4
Cdc23CTXCerebral cortex56.7
39.89
Cdc23HIPHippocampal region51.71
77.9
Cdc23HPFHippocampal formation49.83
58.72
Cdc23HYHypothalamus17.32
12.59
Cdc23LSXLateral septal complex32.67
23.56
Cdc23MBMidbrain32.47
27.55
Cdc23MYMedulla18.71
16.15
Cdc23OLFOlfactory bulb36.59
27.67
Cdc23PPons29.42
28.62
Cdc23PALPallidum15.47
12.18
Cdc23RHPRetrohippocampal region47.59
38.1
Cdc23sAMYStriatum-like amygdalar nuclei16.96
11.5
Cdc23STRStriatum25.45
17.81
Cdc23STRdStriatum dorsal region26.79
19.36
Cdc23STRvStriatum ventral region22.62
14.14
Cdc23THThalamus35.43
31.23
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
CDC23_HUMAN_28 11 28 38 KQLLLIAGLTR PRIDE
CDC23_HUMAN_580 12 580 591 RVSPLNLSSVTP PRIDE
PAp00424992 15 129 143 KKDDETVDSLGPLEK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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