AutismKB 2.0

Annotation Detail for TNFRSF25


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Basic Information Top
Gene Symbol:TNFRSF25 ( APO-3,DDR3,DR3,LARD,TNFRSF12,TR3,TRAMP,WSL-1,WSL-LR )
Gene Full Name: tumor necrosis factor receptor superfamily, member 25
Band: 1p36.31
Quick LinksEntrez ID:8718; OMIM: 603366; Uniprot ID:TNR25_HUMAN; ENSEMBL ID: ENSG00000215788; HGNC ID: 11910
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst1 / 6231916
fetus15 / 56401226
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult31 / 193912115
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor9 / 11936975
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia3 / 9584231
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal55 / 336030716
ovarian tumor1 / 7668213
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites9 / 40015224
bladder0 / 297570 
blood1 / 1234788
bone0 / 716550 
bone marrow0 / 488010 
brain20 / 110098918
cervix2 / 4817141
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye3 / 21105414
heart2 / 8962622
intestine7 / 23447229
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung10 / 33697429
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary1 / 1020519
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate0 / 1893450 
salivary gland0 / 201550 
skin1 / 2105744
spleen6 / 53952111
stomach0 / 966190 
testis1 / 3304423
thymus3 / 8113136
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211841_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.25
Adipocyte4.1
AdrenalCortex4.55
Adrenalgland3.5
Amygdala4.3
Appendix4.25
AtrioventricularNode3.45
BDCA4+_DentriticCells4.7
Bonemarrow4.2
BronchialEpithelialCells4.2
CD105+_Endothelial4.25
CD14+_Monocytes4.55
CD19+_BCells(neg._sel.)4.5
CD33+_Myeloid5.35
CD34+5.4
CD4+_Tcells255
CD56+_NKCells5.7
CD71+_EarlyErythroid3.9
CD8+_Tcells137.8
CardiacMyocytes5.25
Caudatenucleus3.75
Cerebellum3.75
CerebellumPeduncles48.8
CiliaryGanglion3.05
CingulateCortex4.3
Colorectaladenocarcinoma4.2
DorsalRootGanglion3.35
FetalThyroid4.1
Fetalbrain15.1
Fetalliver3.6
Fetallung3.55
GlobusPallidus3.35
Heart5.3
Hypothalamus4.55
Kidney3.45
Leukemia_chronicMyelogenousK-5623.8
Leukemia_promyelocytic-HL-603.65
Leukemialymphoblastic(MOLT-4)3.35
Liver5.45
Lung4.6
Lymphnode15.75
Lymphoma_burkitts(Daudi)5.3
Lymphoma_burkitts(Raji)5.8
MedullaOblongata3.85
OccipitalLobe3.85
OlfactoryBulb3.7
Ovary2.75
Pancreas3.35
PancreaticIslet4.45
ParietalLobe4.4
Pituitary4.9
Placenta4.2
Pons4
PrefrontalCortex5.4
Prostate4.85
Salivarygland3.3
SkeletalMuscle4.8
Skin3.3
SmoothMuscle4.65
Spinalcord4.5
SubthalamicNucleus9.3
SuperiorCervicalGanglion4.8
TemporalLobe3.75
Testis3.5
TestisGermCell3.45
TestisIntersitial3.45
TestisLeydigCell4.15
TestisSeminiferousTubule3.6
Thalamus4.25
Thymus3.35
Thyroid5.1
Tongue4.15
Tonsil6.1
Trachea3.45
TrigeminalGanglion4.3
Uterus3.4
UterusCorpus3.75
WholeBlood4.8
Wholebrain3.55
colon4.15
pineal_day5.18
pineal_night5.04
retina5.025
small_intestine4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9203_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.22 ± 0.87
Basal Forebrain1.49 ± 0.47
Basal Part of Pons1.52 ± 0.41
Cerebellar Cortex2.72 ± 0.52
Cerebellar Nuclei1.87 ± 0.66
Claustrum2.48 ± 0.82
Epithalamus1.95 ± 0.6
Frontal Lobe1.85 ± 0.83
Globus Pallidus1.35 ± 0.42
Hypothalamus1.65 ± 0.79
Insula1.72 ± 0.69
Limbic Lobe2.04 ± 0.84
Mesencephalon1.91 ± 0.9
Myelencephalon1.86 ± 0.75
Occipital Lobe1.85 ± 0.95
Parietal Lobe2.05 ± 0.93
Pontine Tegmentum1.89 ± 0.78
Striatum1.12 ± 0.66
Subthalamus1.87 ± 0.73
Temporal Lobe1.73 ± 0.76
Thalamus1.62 ± 0.7
White Matter1.22 ± 0.24
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tnfrsf25CBCerebellum9.81
13.43
Tnfrsf25CTXCerebral cortex59.01
38.96
Tnfrsf25HIPHippocampal region58.82
79.61
Tnfrsf25HPFHippocampal formation54.34
58.78
Tnfrsf25HYHypothalamus4.52
3.58
Tnfrsf25LSXLateral septal complex10.78
9.47
Tnfrsf25MBMidbrain10.47
10.16
Tnfrsf25MYMedulla11.02
12.46
Tnfrsf25OLFOlfactory bulb43.07
29.99
Tnfrsf25PPons13.46
13.89
Tnfrsf25PALPallidum10.42
8.72
Tnfrsf25RHPRetrohippocampal region48.8
35.99
Tnfrsf25sAMYStriatum-like amygdalar nuclei10.35
7.03
Tnfrsf25STRStriatum20.12
13.25
Tnfrsf25STRdStriatum dorsal region20.79
13.7
Tnfrsf25STRvStriatum ventral region23.14
14.12
Tnfrsf25THThalamus21.8
24.86
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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