Annotation Detail for RIPK1
Basic Information Top
| Gene Symbol: | RIPK1 ( FLJ39204,RIP,RIP1 ) |
|---|---|
| Gene Full Name: | receptor (TNFRSF)-interacting serine-threonine kinase 1 |
| Band: | 6p25.2 |
| Quick Links | Entrez ID:8737; OMIM: 603453; Uniprot ID:RIPK1_HUMAN; ENSEMBL ID: ENSG00000137275; HGNC ID: 10019 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.519842
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 0 / 70761 | 0 | |
| blastocyst | 2 / 62319 | 32 |  |
| fetus | 20 / 564012 | 35 | |
| neonate | 0 / 31097 | 0 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 0 / 55556 | 0 | |
| adult | 82 / 1939121 | 42 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 1 / 17475 | 57 |  |
| breast (mammary gland) tumor | 4 / 94178 | 42 | |
| cervical tumor | 1 / 34366 | 29 | |
| chondrosarcoma | 7 / 82823 | 84 | |
| colorectal tumor | 4 / 114246 | 35 | |
| esophageal tumor | 2 / 17290 | 115 | |
| gastrointestinal tumor | 6 / 119369 | 50 | |
| germ cell tumor | 7 / 263845 | 26 | |
| glioma | 2 / 106883 | 18 | |
| head and neck tumor | 1 / 136302 | 7 |  |
| kidney tumor | 4 / 68959 | 58 | |
| leukemia | 2 / 95842 | 20 | |
| liver tumor | 7 / 96359 | 72 | |
| lung tumor | 0 / 103127 | 0 | |
| lymphoma | 2 / 71755 | 27 | |
| non-neoplasia | 3 / 97250 | 30 | |
| normal | 116 / 3360307 | 34 | |
| ovarian tumor | 5 / 76682 | 65 | |
| pancreatic tumor | 6 / 104616 | 57 | |
| primitive neuroectodermal tumor of the CNS | 2 / 125680 | 15 | |
| prostate cancer | 1 / 102680 | 9 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 1 / 124949 | 8 | |
| soft tissue/muscle tissue tumor | 2 / 125191 | 15 | |
| uterine tumor | 1 / 90257 | 11 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 2 / 33197 | 60 | |
| ascites | 3 / 40015 | 74 | |
| bladder | 3 / 29757 | 100 | |
| blood | 0 / 123478 | 0 | |
| bone | 6 / 71655 | 83 | |
| bone marrow | 3 / 48801 | 61 | |
| brain | 28 / 1100989 | 25 | |
| cervix | 1 / 48171 | 20 | |
| connective tissue | 4 / 149255 | 26 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 2 / 215722 | 9 | |
| esophagus | 2 / 20209 | 98 | |
| eye | 10 / 211054 | 47 | |
| heart | 0 / 89626 | 0 | |
| intestine | 12 / 234472 | 51 | |
| kidney | 8 / 211777 | 37 | |
| larynx | 0 / 24145 | 0 | |
| liver | 10 / 207743 | 48 | |
| lung | 7 / 336974 | 20 | |
| lymph | 1 / 44270 | 22 | |
| lymph node | 2 / 91610 | 21 | |
| mammary gland | 5 / 153271 | 32 | |
| mouth | 0 / 67052 | 0 | |
| muscle | 4 / 107715 | 37 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 6 / 102051 | 58 | |
| pancreas | 7 / 214812 | 32 | |
| parathyroid | 1 / 20539 | 48 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 16 / 280825 | 56 | |
| prostate | 10 / 189345 | 52 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 4 / 210574 | 18 | |
| spleen | 1 / 53952 | 18 | |
| stomach | 4 / 96619 | 41 | |
| testis | 8 / 330442 | 24 | |
| thymus | 2 / 81131 | 24 | |
| thyroid | 1 / 47473 | 21 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 2 / 52413 | 38 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 6 / 232878 | 25 | |
| vascular | 3 / 51780 | 57 | |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 209941_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 6.35 | |
| Adipocyte | 4.95 | |
| AdrenalCortex | 5.15 | |
| Adrenalgland | 4.2 | |
| Amygdala | 5.1 | |
| Appendix | 5.1 | |
| AtrioventricularNode | 4.1 | |
| BDCA4+_DentriticCells | 8.45 | |
| Bonemarrow | 5.1 | |
| BronchialEpithelialCells | 4.85 | |
| CD105+_Endothelial | 5 | |
| CD14+_Monocytes | 5.7 | |
| CD19+_BCells(neg._sel.) | 5.4 | |
| CD33+_Myeloid | 6.45 | |
| CD34+ | 6.4 | |
| CD4+_Tcells | 21.2 | |
| CD56+_NKCells | 23.35 | |
| CD71+_EarlyErythroid | 6.05 | |
| CD8+_Tcells | 25.65 | |
| CardiacMyocytes | 6.55 | |
| Caudatenucleus | 4.35 | |
| Cerebellum | 4 | |
| CerebellumPeduncles | 5.65 | |
| CiliaryGanglion | 3.8 | |
| CingulateCortex | 5.05 | |
| Colorectaladenocarcinoma | 5.9 | |
| DorsalRootGanglion | 3.9 | |
| FetalThyroid | 4.7 | |
| Fetalbrain | 4.9 | |
| Fetalliver | 4.35 | |
| Fetallung | 3.9 | |
| GlobusPallidus | 3.65 | |
| Heart | 6.45 | |
| Hypothalamus | 5.2 | |
| Kidney | 4.05 | |
| Leukemia_chronicMyelogenousK-562 | 4.45 | |
| Leukemia_promyelocytic-HL-60 | 4.35 | |
| Leukemialymphoblastic(MOLT-4) | 3.9 | |
| Liver | 6.65 | |
| Lung | 5.3 | |
| Lymphnode | 4.8 | |
| Lymphoma_burkitts(Daudi) | 6.35 | |
| Lymphoma_burkitts(Raji) | 6.9 | |
| MedullaOblongata | 4.4 | |
| OccipitalLobe | 4.4 | |
| OlfactoryBulb | 3.85 | |
| Ovary | 3.4 | |
| Pancreas | 4 | |
| PancreaticIslet | 7.4 | |
| ParietalLobe | 5.2 | |
| Pituitary | 5.7 | |
| Placenta | 7.85 | |
| Pons | 4.7 | |
| PrefrontalCortex | 6.05 | |
| Prostate | 5.65 | |
| Salivarygland | 3.95 | |
| SkeletalMuscle | 6.2 | |
| Skin | 5.2 | |
| SmoothMuscle | 5.9 | |
| Spinalcord | 5.3 | |
| SubthalamicNucleus | 4.5 | |
| SuperiorCervicalGanglion | 5.9 | |
| TemporalLobe | 4.45 | |
| Testis | 4.15 | |
| TestisGermCell | 3.95 | |
| TestisIntersitial | 4.1 | |
| TestisLeydigCell | 4.9 | |
| TestisSeminiferousTubule | 4.15 | |
| Thalamus | 5 | |
| Thymus | 3.85 | |
| Thyroid | 8.1 | |
| Tongue | 4.8 | |
| Tonsil | 4.85 | |
| Trachea | 4.15 | |
| TrigeminalGanglion | 5.6 | |
| Uterus | 4.1 | |
| UterusCorpus | 4.45 | |
| WholeBlood | 9.15 | |
| Wholebrain | 4 | |
| colon | 5 | |
| pineal_day | 6.12 | |
| pineal_night | 6.06 | |
| retina | 6.075 | |
| small_intestine | 4.8 | |
- Probe name: CUST_16284_PI416261804
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 5.2 ± 0.58 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 4.92 ± 0.25 | |
| Basal Part of Pons | 4.81 ± 0.41 | |
| Cerebellar Cortex | 5.25 ± 0.31 | |
| Cerebellar Nuclei | 4.83 ± 0.56 | |
| Claustrum | 5.36 ± 0.59 | |
| Epithalamus | 5.03 ± 0.33 | |
| Frontal Lobe | 4.64 ± 0.49 | |
| Globus Pallidus | 5.08 ± 0.31 | |
| Hypothalamus | 4.88 ± 0.34 | |
| Insula | 4.98 ± 0.42 | |
| Limbic Lobe | 4.94 ± 0.56 | |
| Mesencephalon | 5.02 ± 0.49 | |
| Myelencephalon | 4.96 ± 0.48 | |
| Occipital Lobe | 5.33 ± 0.48 | |
| Parietal Lobe | 4.96 ± 0.46 | |
| Pontine Tegmentum | 4.85 ± 0.57 | |
| Striatum | 4.64 ± 0.38 | |
| Subthalamus | 4.53 ± 0.22 | |
| Temporal Lobe | 4.92 ± 0.43 | |
| Thalamus | 5.07 ± 0.46 | |
| White Matter | 5.31 ± 0.33 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Ripk1 | CB | Cerebellum | 3.35 | |
| 3.92 | | |||
| Ripk1 | CTX | Cerebral cortex | 3.75 | |
| 3.02 | | |||
| Ripk1 | HIP | Hippocampal region | 5.79 | |
| 5.44 | | |||
| Ripk1 | HPF | Hippocampal formation | 4.7 | |
| 4.27 | | |||
| Ripk1 | HY | Hypothalamus | 0.68 | |
| 0.94 | | |||
| Ripk1 | LSX | Lateral septal complex | 0.28 | |
| 0.19 | | |||
| Ripk1 | MB | Midbrain | 1.04 | |
| 1.32 | | |||
| Ripk1 | MY | Medulla | 1.8 | |
| 2.14 | | |||
| Ripk1 | OLF | Olfactory bulb | 4.6 | |
| 4.42 | | |||
| Ripk1 | P | Pons | 1.99 | |
| 2.74 | | |||
| Ripk1 | PAL | Pallidum | 0.85 | |
| 0.85 | | |||
| Ripk1 | RHP | Retrohippocampal region | 3.2 | |
| 2.87 | | |||
| Ripk1 | sAMY | Striatum-like amygdalar nuclei | 2.47 | |
| 1.91 | | |||
| Ripk1 | STR | Striatum | 1.28 | |
| 1.29 | | |||
| Ripk1 | STRd | Striatum dorsal region | 1.29 | |
| 1.41 | | |||
| Ripk1 | STRv | Striatum ventral region | 1.13 | |
| 1.04 | | |||
| Ripk1 | TH | Thalamus | 1.42 | |
| 1.63 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| PAp00096310 | 10 | 649 | 658 | LAQALHQCSR | Peptide Atlas |