AutismKB 2.0

Annotation Detail for TNFSF10


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:TNFSF10 ( APO2L,Apo-2L,CD253,TL2,TRAIL )
Gene Full Name: tumor necrosis factor (ligand) superfamily, member 10
Band: 3q26
Quick LinksEntrez ID:8743; OMIM: 603598; Uniprot ID:TNF10_HUMAN; ENSEMBL ID: ENSG00000121858; HGNC ID: 11925
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus13 / 56401223
neonate2 / 3109764
infant0 / 236200 
juvenile3 / 5555653
adult158 / 193912181
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma1 / 1747557
breast (mammary gland) tumor9 / 9417895
cervical tumor1 / 3436629
chondrosarcoma2 / 8282324
colorectal tumor5 / 11424643
esophageal tumor6 / 17290347
gastrointestinal tumor4 / 11936933
germ cell tumor5 / 26384518
glioma0 / 1068830 
head and neck tumor10 / 13630273
kidney tumor2 / 6895929
leukemia2 / 9584220
liver tumor4 / 9635941
lung tumor0 / 1031270 
lymphoma3 / 7175541
non-neoplasia8 / 9725082
normal212 / 336030763
ovarian tumor13 / 76682169
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland7 / 33197210
ascites0 / 400150 
bladder3 / 29757100
blood8 / 12347864
bone0 / 716550 
bone marrow2 / 4880140
brain22 / 110098919
cervix1 / 4817120
connective tissue5 / 14925533
ear2 / 16212123
embryonic tissue0 / 2157220 
esophagus6 / 20209296
eye4 / 21105418
heart3 / 8962633
intestine21 / 23447289
kidney37 / 211777174
larynx4 / 24145165
liver6 / 20774328
lung34 / 336974100
lymph1 / 4427022
lymph node5 / 9161054
mammary gland21 / 153271137
mouth4 / 6705259
muscle5 / 10771546
nerve0 / 157680 
ovary16 / 102051156
pancreas13 / 21481260
parathyroid3 / 20539146
pharynx11 / 41328266
pituitary gland0 / 165850 
placenta49 / 280825174
prostate21 / 189345110
salivary gland0 / 201550 
skin5 / 21057423
spleen2 / 5395237
stomach6 / 9661962
testis3 / 3304429
thymus1 / 8113112
thyroid3 / 4747363
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord2 / 13680146
uterus13 / 23287855
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 214329_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts10.15
Adipocyte8.45
AdrenalCortex12.15
Adrenalgland8
Amygdala9.25
Appendix13.45
AtrioventricularNode8.5
BDCA4+_DentriticCells13.45
Bonemarrow9.35
BronchialEpithelialCells8.45
CD105+_Endothelial9.1
CD14+_Monocytes83.65
CD19+_BCells(neg._sel.)10.9
CD33+_Myeloid47.75
CD34+11
CD4+_Tcells9.45
CD56+_NKCells10.7
CD71+_EarlyErythroid8.3
CD8+_Tcells8.75
CardiacMyocytes12.9
Caudatenucleus8.05
Cerebellum7.15
CerebellumPeduncles10.8
CiliaryGanglion8.1
CingulateCortex9.4
Colorectaladenocarcinoma18.4
DorsalRootGanglion7.6
FetalThyroid8.85
Fetalbrain8.5
Fetalliver8.05
Fetallung9.3
GlobusPallidus7.1
Heart12.75
Hypothalamus9.6
Kidney8.4
Leukemia_chronicMyelogenousK-5627.75
Leukemia_promyelocytic-HL-607.85
Leukemialymphoblastic(MOLT-4)6.95
Liver13.3
Lung11.65
Lymphnode38.5
Lymphoma_burkitts(Daudi)11.9
Lymphoma_burkitts(Raji)13.9
MedullaOblongata8
OccipitalLobe7.95
OlfactoryBulb7.1
Ovary6.25
Pancreas7.9
PancreaticIslet9.75
ParietalLobe10.05
Pituitary10.2
Placenta12.15
Pons8.9
PrefrontalCortex10.75
Prostate109.55
Salivarygland7.55
SkeletalMuscle11.45
Skin8.35
SmoothMuscle9.85
Spinalcord10.6
SubthalamicNucleus8.95
SuperiorCervicalGanglion13.05
TemporalLobe8.6
Testis7.45
TestisGermCell7.1
TestisIntersitial7.6
TestisLeydigCell9.25
TestisSeminiferousTubule7.4
Thalamus9.3
Thymus6.75
Thyroid34.7
Tongue10.45
Tonsil9.2
Trachea14.05
TrigeminalGanglion13
Uterus15.75
UterusCorpus8.85
WholeBlood377.7
Wholebrain6.6
colon94.05
pineal_day11.04
pineal_night10.9
retina15.65
small_intestine52.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P126023
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.26 ± 0.96
Basal Forebrain1.75 ± 0.19
Basal Part of Pons1.41 ± 0.36
Cerebellar Cortex1.61 ± 0.68
Cerebellar Nuclei2.1 ± 0.72
Claustrum2.68 ± 0.88
Epithalamus1.5 ± 0.61
Frontal Lobe1.6 ± 0.55
Globus Pallidus2.44 ± 0.27
Hypothalamus2.02 ± 0.55
Insula1.66 ± 0.47
Limbic Lobe1.78 ± 0.6
Mesencephalon1.93 ± 0.63
Myelencephalon1.8 ± 0.64
Occipital Lobe1.83 ± 0.55
Parietal Lobe1.79 ± 0.65
Pontine Tegmentum1.84 ± 0.68
Striatum2.06 ± 0.87
Subthalamus1.91 ± 0.56
Temporal Lobe1.67 ± 0.6
Thalamus1.78 ± 0.72
White Matter2.36 ± 0.42
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved