Annotation Detail for CBS
Basic Information Top
| Gene Symbol: | CBS ( HIP4 ) |
|---|---|
| Gene Full Name: | cystathionine-beta-synthase |
| Band: | 21q22.3 |
| Quick Links | Entrez ID:875; OMIM: 613381; Uniprot ID:CBS_HUMAN; ENSEMBL ID: ENSG00000160200; HGNC ID: 1550 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.533013
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 6 / 70761 | 84 |  |
| blastocyst | 22 / 62319 | 353 |  |
| fetus | 39 / 564012 | 69 | |
| neonate | 1 / 31097 | 32 |  |
| infant | 2 / 23620 | 84 | |
| juvenile | 6 / 55556 | 107 | |
| adult | 88 / 1939121 | 45 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 3 / 94178 | 31 | |
| cervical tumor | 10 / 34366 | 290 | |
| chondrosarcoma | 3 / 82823 | 36 | |
| colorectal tumor | 6 / 114246 | 52 | |
| esophageal tumor | 1 / 17290 | 57 | |
| gastrointestinal tumor | 5 / 119369 | 41 | |
| germ cell tumor | 16 / 263845 | 60 | |
| glioma | 17 / 106883 | 159 | |
| head and neck tumor | 2 / 136302 | 14 | |
| kidney tumor | 4 / 68959 | 58 | |
| leukemia | 3 / 95842 | 31 | |
| liver tumor | 7 / 96359 | 72 | |
| lung tumor | 22 / 103127 | 213 | |
| lymphoma | 28 / 71755 | 390 | |
| non-neoplasia | 1 / 97250 | 10 |  |
| normal | 171 / 3360307 | 50 | |
| ovarian tumor | 12 / 76682 | 156 | |
| pancreatic tumor | 5 / 104616 | 47 | |
| primitive neuroectodermal tumor of the CNS | 22 / 125680 | 175 | |
| prostate cancer | 10 / 102680 | 97 | |
| retinoblastoma | 32 / 46356 | 690 | |
| skin tumor | 1 / 124949 | 8 | |
| soft tissue/muscle tissue tumor | 20 / 125191 | 159 | |
| uterine tumor | 6 / 90257 | 66 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 1 / 29757 | 33 | |
| blood | 3 / 123478 | 24 | |
| bone | 3 / 71655 | 41 | |
| bone marrow | 0 / 48801 | 0 | |
| brain | 106 / 1100989 | 96 | |
| cervix | 12 / 48171 | 249 | |
| connective tissue | 3 / 149255 | 20 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 39 / 215722 | 180 | |
| esophagus | 1 / 20209 | 49 | |
| eye | 39 / 211054 | 184 | |
| heart | 0 / 89626 | 0 | |
| intestine | 9 / 234472 | 38 | |
| kidney | 4 / 211777 | 18 | |
| larynx | 0 / 24145 | 0 | |
| liver | 23 / 207743 | 110 | |
| lung | 26 / 336974 | 77 | |
| lymph | 28 / 44270 | 632 | |
| lymph node | 2 / 91610 | 21 | |
| mammary gland | 4 / 153271 | 26 | |
| mouth | 2 / 67052 | 29 | |
| muscle | 19 / 107715 | 176 | |
| nerve | 4 / 15768 | 253 | |
| ovary | 17 / 102051 | 166 | |
| pancreas | 12 / 214812 | 55 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 1 / 16585 | 60 | |
| placenta | 7 / 280825 | 24 | |
| prostate | 17 / 189345 | 89 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 4 / 210574 | 18 | |
| spleen | 2 / 53952 | 37 | |
| stomach | 4 / 96619 | 41 | |
| testis | 8 / 330442 | 24 | |
| thymus | 0 / 81131 | 0 | |
| thyroid | 1 / 47473 | 21 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 1 / 52413 | 19 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 9 / 232878 | 38 | |
| vascular | 1 / 51780 | 19 | |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 212816_s_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 6.8 | |
| Adipocyte | 7.6 | |
| AdrenalCortex | 6.8 | |
| Adrenalgland | 5.3 | |
| Amygdala | 22 | |
| Appendix | 6.3 | |
| AtrioventricularNode | 5.25 | |
| BDCA4+_DentriticCells | 6.05 | |
| Bonemarrow | 6.25 | |
| BronchialEpithelialCells | 7 | |
| CD105+_Endothelial | 6.1 | |
| CD14+_Monocytes | 6.15 | |
| CD19+_BCells(neg._sel.) | 6.3 | |
| CD33+_Myeloid | 7.6 | |
| CD34+ | 7.2 | |
| CD4+_Tcells | 6.35 | |
| CD56+_NKCells | 6.95 | |
| CD71+_EarlyErythroid | 5.8 | |
| CD8+_Tcells | 5.45 | |
| CardiacMyocytes | 22.5 | |
| Caudatenucleus | 6.7 | |
| Cerebellum | 25.5 | |
| CerebellumPeduncles | 22.7 | |
| CiliaryGanglion | 4.35 | |
| CingulateCortex | 8.6 | |
| Colorectaladenocarcinoma | 70.25 | |
| DorsalRootGanglion | 4.7 | |
| FetalThyroid | 6.3 | |
| Fetalbrain | 8.2 | |
| Fetalliver | 21.15 | |
| Fetallung | 5.95 | |
| GlobusPallidus | 4.65 | |
| Heart | 8.05 | |
| Hypothalamus | 9.8 | |
| Kidney | 5.05 | |
| Leukemia_chronicMyelogenousK-562 | 116.05 | |
| Leukemia_promyelocytic-HL-60 | 18.8 | |
| Leukemialymphoblastic(MOLT-4) | 10.6 | |
| Liver | 134.05 | |
| Lung | 7.15 | |
| Lymphnode | 5.1 | |
| Lymphoma_burkitts(Daudi) | 7.85 | |
| Lymphoma_burkitts(Raji) | 96.95 | |
| MedullaOblongata | 7.05 | |
| OccipitalLobe | 5.9 | |
| OlfactoryBulb | 10.65 | |
| Ovary | 4.25 | |
| Pancreas | 32.55 | |
| PancreaticIslet | 24.35 | |
| ParietalLobe | 9.2 | |
| Pituitary | 7.35 | |
| Placenta | 5.8 | |
| Pons | 6.05 | |
| PrefrontalCortex | 15.3 | |
| Prostate | 17.2 | |
| Salivarygland | 4.8 | |
| SkeletalMuscle | 7.3 | |
| Skin | 4.7 | |
| SmoothMuscle | 12.7 | |
| Spinalcord | 12.25 | |
| SubthalamicNucleus | 7.8 | |
| SuperiorCervicalGanglion | 7.35 | |
| TemporalLobe | 5.8 | |
| Testis | 5 | |
| TestisGermCell | 4.9 | |
| TestisIntersitial | 5.2 | |
| TestisLeydigCell | 6.25 | |
| TestisSeminiferousTubule | 5.2 | |
| Thalamus | 9.6 | |
| Thymus | 4.6 | |
| Thyroid | 15.8 | |
| Tongue | 6.05 | |
| Tonsil | 5.9 | |
| Trachea | 5.45 | |
| TrigeminalGanglion | 6.45 | |
| Uterus | 4.8 | |
| UterusCorpus | 5.5 | |
| WholeBlood | 6.55 | |
| Wholebrain | 20.9 | |
| colon | 6.05 | |
| pineal_day | 7.74 | |
| pineal_night | 7.46 | |
| retina | 9.5 | |
| small_intestine | 5.85 | |
- Probe name: A_24_P48856
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 4.84 ± 0.65 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 5.41 ± 0.28 | |
| Basal Part of Pons | 5.66 ± 0.33 | |
| Cerebellar Cortex | 5.75 ± 0.37 | |
| Cerebellar Nuclei | 5 ± 0.54 | |
| Claustrum | 5.51 ± 0.52 | |
| Epithalamus | 5.3 ± 0.57 | |
| Frontal Lobe | 5.42 ± 0.55 | |
| Globus Pallidus | 4.92 ± 0.39 | |
| Hypothalamus | 5.52 ± 0.32 | |
| Insula | 5.05 ± 0.51 | |
| Limbic Lobe | 4.96 ± 0.62 | |
| Mesencephalon | 5.09 ± 0.62 | |
| Myelencephalon | 5.19 ± 0.57 | |
| Occipital Lobe | 4.86 ± 0.59 | |
| Parietal Lobe | 5.04 ± 0.51 | |
| Pontine Tegmentum | 4.93 ± 0.67 | |
| Striatum | 4.61 ± 0.44 | |
| Subthalamus | 4.1 ± 0.86 | |
| Temporal Lobe | 5.01 ± 0.59 | |
| Thalamus | 5.57 ± 0.38 | |
| White Matter | 4.89 ± 0.53 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Cbs | CB | Cerebellum | 17.08 | |
| 27.32 | | |||
| Cbs | CTX | Cerebral cortex | 11.86 | |
| 7.31 | | |||
| Cbs | HIP | Hippocampal region | 20.43 | |
| 16.37 | | |||
| Cbs | HPF | Hippocampal formation | 21.62 | |
| 16.42 | | |||
| Cbs | HY | Hypothalamus | 7.69 | |
| 5.23 | | |||
| Cbs | LSX | Lateral septal complex | 15.87 | |
| 11.51 | | |||
| Cbs | MB | Midbrain | 6.58 | |
| 5.38 | | |||
| Cbs | MY | Medulla | 8.54 | |
| 8.21 | | |||
| Cbs | OLF | Olfactory bulb | 13.93 | |
| 9.5 | | |||
| Cbs | P | Pons | 10.13 | |
| 9 | | |||
| Cbs | PAL | Pallidum | 10.22 | |
| 6.89 | | |||
| Cbs | RHP | Retrohippocampal region | 24.01 | |
| 16.71 | | |||
| Cbs | sAMY | Striatum-like amygdalar nuclei | 13.41 | |
| 8.83 | | |||
| Cbs | STR | Striatum | 11.49 | |
| 7.72 | | |||
| Cbs | STRd | Striatum dorsal region | 11.04 | |
| 7.88 | | |||
| Cbs | STRv | Striatum ventral region | 9.93 | |
| 5.37 | | |||
| Cbs | TH | Thalamus | 6.79 | |
| 4.93 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| CBS_HUMAN_1 | 17 | 1 | 17 | PSETPQAEVGPTGCPHR | PRIDE |
| PAp00006297 | 17 | 2 | 18 | PSETPQAEVGPTGCPHR | Peptide Atlas |