AutismKB 2.0

Annotation Detail for RIPK2


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Basic Information Top
Gene Symbol:RIPK2 ( CARD3,CARDIAK,CCK,GIG30,RICK,RIP2 )
Gene Full Name: receptor-interacting serine-threonine kinase 2
Band: 8q21.3
Quick LinksEntrez ID:8767; OMIM: 603455; Uniprot ID:RIPK2_HUMAN; ENSEMBL ID: ENSG00000104312; HGNC ID: 10020
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst1 / 6231916
fetus5 / 5640128
neonate1 / 3109732
infant0 / 236200 
juvenile3 / 5555653
adult94 / 193912148
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor4 / 34366116
chondrosarcoma5 / 8282360
colorectal tumor6 / 11424652
esophageal tumor2 / 17290115
gastrointestinal tumor18 / 119369150
germ cell tumor9 / 26384534
glioma2 / 10688318
head and neck tumor1 / 1363027
kidney tumor1 / 6895914
leukemia5 / 9584252
liver tumor4 / 9635941
lung tumor4 / 10312738
lymphoma5 / 7175569
non-neoplasia3 / 9725030
normal82 / 336030724
ovarian tumor0 / 766820 
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor5 / 12494940
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites3 / 4001574
bladder1 / 2975733
blood3 / 12347824
bone5 / 7165569
bone marrow1 / 4880120
brain28 / 110098925
cervix6 / 48171124
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus2 / 2020998
eye2 / 2110549
heart2 / 8962622
intestine11 / 23447246
kidney6 / 21177728
larynx1 / 2414541
liver4 / 20774319
lung12 / 33697435
lymph3 / 4427067
lymph node8 / 9161087
mammary gland10 / 15327165
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary1 / 1020519
pancreas3 / 21481213
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta22 / 28082578
prostate4 / 18934521
salivary gland1 / 2015549
skin6 / 21057428
spleen2 / 5395237
stomach11 / 96619113
testis8 / 33044224
thymus2 / 8113124
thyroid0 / 474730 
tonsil1 / 1699958
trachea1 / 5241319
umbilical cord0 / 136800 
uterus5 / 23287821
vascular7 / 51780135
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209544_at
Cell line Expression level Expression bar
721_B_lymphoblasts12.25
Adipocyte12.2
AdrenalCortex21.4
Adrenalgland13.1
Amygdala11.15
Appendix24
AtrioventricularNode21.25
BDCA4+_DentriticCells9.9
Bonemarrow17.65
BronchialEpithelialCells11.05
CD105+_Endothelial11.95
CD14+_Monocytes13.85
CD19+_BCells(neg._sel.)12.45
CD33+_Myeloid20.35
CD34+14.2
CD4+_Tcells10.85
CD56+_NKCells12.3
CD71+_EarlyErythroid13
CD8+_Tcells9.05
CardiacMyocytes34.85
Caudatenucleus15.05
Cerebellum11.15
CerebellumPeduncles18.2
CiliaryGanglion19.4
CingulateCortex14.05
Colorectaladenocarcinoma12.1
DorsalRootGanglion15.8
FetalThyroid14.25
Fetalbrain11.75
Fetalliver12.05
Fetallung8.8
GlobusPallidus12.75
Heart29.8
Hypothalamus11.7
Kidney14.2
Leukemia_chronicMyelogenousK-56211.6
Leukemia_promyelocytic-HL-6011.15
Leukemialymphoblastic(MOLT-4)8.85
Liver25.35
Lung13.8
Lymphnode10.35
Lymphoma_burkitts(Daudi)18.75
Lymphoma_burkitts(Raji)32
MedullaOblongata15.1
OccipitalLobe10.85
OlfactoryBulb10.15
Ovary12.1
Pancreas11.55
PancreaticIslet14.5
ParietalLobe17.4
Pituitary23.25
Placenta11.9
Pons13.8
PrefrontalCortex12.45
Prostate13.3
Salivarygland11.85
SkeletalMuscle32.75
Skin19.65
SmoothMuscle17.55
Spinalcord19.8
SubthalamicNucleus14.9
SuperiorCervicalGanglion36.1
TemporalLobe13.05
Testis11.2
TestisGermCell8.65
TestisIntersitial11.25
TestisLeydigCell14.95
TestisSeminiferousTubule10.85
Thalamus14.05
Thymus10.3
Thyroid12.95
Tongue19.25
Tonsil13.7
Trachea10.8
TrigeminalGanglion23.85
Uterus8.9
UterusCorpus16.65
WholeBlood13.05
Wholebrain9.2
colon12.85
pineal_day14.26
pineal_night13.94
retina14.8
small_intestine10.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P252106
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.83 ± 0.33
Basal Forebrain6.58 ± 0.29
Basal Part of Pons6.44 ± 0.23
Cerebellar Cortex6.36 ± 0.29
Cerebellar Nuclei6.67 ± 0.34
Claustrum7.07 ± 0.3
Epithalamus7.3 ± 0.37
Frontal Lobe6.71 ± 0.36
Globus Pallidus7.25 ± 0.11
Hypothalamus6.84 ± 0.58
Insula6.91 ± 0.17
Limbic Lobe6.92 ± 0.26
Mesencephalon6.75 ± 0.35
Myelencephalon6.75 ± 0.41
Occipital Lobe6.51 ± 0.3
Parietal Lobe6.68 ± 0.39
Pontine Tegmentum6.76 ± 0.31
Striatum6.5 ± 0.49
Subthalamus6.35 ± 0.39
Temporal Lobe6.84 ± 0.3
Thalamus6.41 ± 0.36
White Matter7.41 ± 0.29
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ripk2CBCerebellum2.63
3.98
Ripk2CTXCerebral cortex1.72
1.71
Ripk2HIPHippocampal region1.74
1.52
Ripk2HPFHippocampal formation1.45
1.18
Ripk2HYHypothalamus0.65
0.5
Ripk2LSXLateral septal complex0.31
0.31
Ripk2MBMidbrain1.13
1.14
Ripk2MYMedulla1.02
1.1
Ripk2OLFOlfactory bulb1.87
2.84
Ripk2PPons0.84
0.89
Ripk2PALPallidum0.38
0.35
Ripk2RHPRetrohippocampal region1.03
0.76
Ripk2sAMYStriatum-like amygdalar nuclei0.48
0.3
Ripk2STRStriatum0.36
0.35
Ripk2STRdStriatum dorsal region0.36
0.4
Ripk2STRvStriatum ventral region0.33
0.27
Ripk2THThalamus0.93
1.02
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00079553 20 411 430 TTPCSSAIINPLSTAGNSER Peptide Atlas
RIPK2_HUMAN_514 15 514 528 QMGLQPYPEILVVSR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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