AutismKB 2.0

Annotation Detail for MPDZ


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Basic Information Top
Gene Symbol:MPDZ ( DKFZp781P216,FLJ25909,FLJ34626,FLJ90240,MUPP1 )
Gene Full Name: multiple PDZ domain protein
Band: 9p23
Quick LinksEntrez ID:8777; OMIM: 603785; Uniprot ID:MPDZ_HUMAN; ENSEMBL ID: ENSG00000107186; HGNC ID: 7208
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body9 / 70761127
blastocyst2 / 6231932
fetus26 / 56401246
neonate2 / 3109764
infant2 / 2362084
juvenile5 / 5555689
adult97 / 193912150
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor2 / 9417821
cervical tumor1 / 3436629
chondrosarcoma2 / 8282324
colorectal tumor1 / 1142468
esophageal tumor1 / 1729057
gastrointestinal tumor0 / 1193690 
germ cell tumor5 / 26384518
glioma2 / 10688318
head and neck tumor3 / 13630222
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor11 / 96359114
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal169 / 336030750
ovarian tumor1 / 7668213
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor3 / 12494924
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone2 / 7165527
bone marrow0 / 488010 
brain69 / 110098962
cervix1 / 4817120
connective tissue1 / 1492556
ear1 / 1621261
embryonic tissue17 / 21572278
esophagus1 / 2020949
eye11 / 21105452
heart8 / 8962689
intestine2 / 2344728
kidney10 / 21177747
larynx0 / 241450 
liver25 / 207743120
lung5 / 33697414
lymph0 / 442700 
lymph node0 / 916100 
mammary gland19 / 153271123
mouth2 / 6705229
muscle6 / 10771555
nerve4 / 15768253
ovary2 / 10205119
pancreas2 / 2148129
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland2 / 16585120
placenta5 / 28082517
prostate4 / 18934521
salivary gland0 / 201550 
skin4 / 21057418
spleen1 / 5395218
stomach0 / 966190 
testis8 / 33044224
thymus2 / 8113124
thyroid2 / 4747342
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord2 / 13680146
uterus11 / 23287847
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205079_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.6
Adipocyte7.9
AdrenalCortex6.5
Adrenalgland5.25
Amygdala25.35
Appendix11.95
AtrioventricularNode12.1
BDCA4+_DentriticCells5.85
Bonemarrow6.15
BronchialEpithelialCells5.85
CD105+_Endothelial5.85
CD14+_Monocytes6.2
CD19+_BCells(neg._sel.)6.1
CD33+_Myeloid7.25
CD34+7.3
CD4+_Tcells6.05
CD56+_NKCells6.45
CD71+_EarlyErythroid5.5
CD8+_Tcells5.5
CardiacMyocytes9.6
Caudatenucleus8.9
Cerebellum4.8
CerebellumPeduncles6.8
CiliaryGanglion6.6
CingulateCortex11.45
Colorectaladenocarcinoma6.1
DorsalRootGanglion10.45
FetalThyroid9.45
Fetalbrain10.75
Fetalliver5.65
Fetallung6.95
GlobusPallidus7.15
Heart8.3
Hypothalamus20
Kidney4.8
Leukemia_chronicMyelogenousK-5625.4
Leukemia_promyelocytic-HL-605.15
Leukemialymphoblastic(MOLT-4)4.55
Liver8.6
Lung6.65
Lymphnode4.95
Lymphoma_burkitts(Daudi)7.55
Lymphoma_burkitts(Raji)8.55
MedullaOblongata13.95
OccipitalLobe13.05
OlfactoryBulb30.7
Ovary5
Pancreas4.9
PancreaticIslet6.4
ParietalLobe11.35
Pituitary16.3
Placenta5.8
Pons10.2
PrefrontalCortex23.3
Prostate10.5
Salivarygland5
SkeletalMuscle8.35
Skin5.15
SmoothMuscle6.7
Spinalcord15.35
SubthalamicNucleus5.9
SuperiorCervicalGanglion16
TemporalLobe6.5
Testis5.05
TestisGermCell10.55
TestisIntersitial5.7
TestisLeydigCell6.1
TestisSeminiferousTubule6.05
Thalamus7.65
Thymus4.55
Thyroid9.55
Tongue6.2
Tonsil5.75
Trachea5.1
TrigeminalGanglion17.75
Uterus35.1
UterusCorpus6.4
WholeBlood6.55
Wholebrain6.85
colon6
pineal_day106.66
pineal_night101.26
retina22.35
small_intestine5.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P396328
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.53 ± 0.46
Basal Forebrain7.69 ± 0.21
Basal Part of Pons7.8 ± 0.51
Cerebellar Cortex7.76 ± 0.24
Cerebellar Nuclei7.88 ± 0.32
Claustrum7.07 ± 0.81
Epithalamus8.78 ± 0.58
Frontal Lobe7.76 ± 0.5
Globus Pallidus8.35 ± 0.27
Hypothalamus7.77 ± 0.32
Insula7.91 ± 0.37
Limbic Lobe7.48 ± 0.48
Mesencephalon7.69 ± 0.5
Myelencephalon7.67 ± 0.47
Occipital Lobe7.37 ± 0.42
Parietal Lobe7.61 ± 0.43
Pontine Tegmentum7.61 ± 0.38
Striatum7.37 ± 0.5
Subthalamus7.96 ± 0.21
Temporal Lobe7.73 ± 0.33
Thalamus7.59 ± 0.39
White Matter9.32 ± 0.35
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
MpdzCBCerebellum21.22
52.25
MpdzCTXCerebral cortex69.4
61.83
MpdzHIPHippocampal region65.99
100
MpdzHPFHippocampal formation63.92
82.75
MpdzHYHypothalamus15.76
11.81
MpdzLSXLateral septal complex24.24
20.76
MpdzMBMidbrain17.39
16.34
MpdzMYMedulla29.19
35.08
MpdzOLFOlfactory bulb55.14
51.26
MpdzPPons23.61
26.78
MpdzPALPallidum20.55
19.77
MpdzRHPRetrohippocampal region59.84
54.52
MpdzsAMYStriatum-like amygdalar nuclei28.73
29.69
MpdzSTRStriatum13.24
12.16
MpdzSTRdStriatum dorsal region10.88
10.01
MpdzSTRvStriatum ventral region7.33
5.48
MpdzTHThalamus40.87
37.23
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
MPDZ_HUMAN_305 19 305 323 IGDTDLAGMSSEQVAQVLR PRIDE
MPDZ_HUMAN_450 12 450 461 HTGQTVLLTLMR PRIDE
PAp00438663 10 1161 1170 SLGISIVGGR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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