AutismKB 2.0

Annotation Detail for DLK1


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Basic Information Top
Gene Symbol:DLK1 ( DLK,FA1,PREF1,Pref-1,ZOG,pG2 )
Gene Full Name: delta-like 1 homolog (Drosophila)
Band: 14q32.2
Quick LinksEntrez ID:8788; OMIM: 176290; Uniprot ID:DLK1_HUMAN; ENSEMBL ID: ENSG00000185559; HGNC ID: 2907
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body8 / 70761113
blastocyst2 / 6231932
fetus55 / 56401297
neonate3 / 3109796
infant0 / 236200 
juvenile2 / 5555635
adult751 / 1939121387
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor39 / 127943048
bladder carcinoma0 / 174750 
breast (mammary gland) tumor7 / 9417874
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor3 / 26384511
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor3 / 9635931
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal866 / 3360307257
ovarian tumor0 / 766820 
pancreatic tumor102 / 104616974
primitive neuroectodermal tumor of the CNS214 / 1256801702
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland51 / 331971536
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow1 / 4880120
brain29 / 110098926
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue25 / 215722115
esophagus0 / 202090 
eye5 / 21105423
heart3 / 8962633
intestine0 / 2344720 
kidney7 / 21177733
larynx0 / 241450 
liver16 / 20774377
lung8 / 33697423
lymph0 / 442700 
lymph node0 / 916100 
mammary gland7 / 15327145
mouth18 / 67052268
muscle0 / 1077150 
nerve3 / 15768190
ovary1 / 1020519
pancreas106 / 214812493
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland33 / 165851989
placenta718 / 2808252556
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis5 / 33044215
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord3 / 13680219
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209560_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.6
Adipocyte3.6
AdrenalCortex5784.3
Adrenalgland6516.2
Amygdala3.85
Appendix6.1
AtrioventricularNode2.8
BDCA4+_DentriticCells4.1
Bonemarrow3.65
BronchialEpithelialCells3.6
CD105+_Endothelial3.8
CD14+_Monocytes3.9
CD19+_BCells(neg._sel.)3.95
CD33+_Myeloid4.75
CD34+5.75
CD4+_Tcells4
CD56+_NKCells4.4
CD71+_EarlyErythroid3.45
CD8+_Tcells3.55
CardiacMyocytes4.8
Caudatenucleus3.25
Cerebellum3
CerebellumPeduncles4.15
CiliaryGanglion2.6
CingulateCortex3.75
Colorectaladenocarcinoma3.7
DorsalRootGanglion2.9
FetalThyroid102.25
Fetalbrain3.65
Fetalliver2842.5
Fetallung666.65
GlobusPallidus2.7
Heart74.9
Hypothalamus5.5
Kidney3
Leukemia_chronicMyelogenousK-56293.8
Leukemia_promyelocytic-HL-603.3
Leukemialymphoblastic(MOLT-4)3
Liver4.85
Lung4
Lymphnode3.15
Lymphoma_burkitts(Daudi)4.85
Lymphoma_burkitts(Raji)5.15
MedullaOblongata3.35
OccipitalLobe3.25
OlfactoryBulb2.9
Ovary1331.4
Pancreas6
PancreaticIslet293.05
ParietalLobe3.9
Pituitary6702.45
Placenta8649.65
Pons3.5
PrefrontalCortex4.6
Prostate4.3
Salivarygland3
SkeletalMuscle4.25
Skin3.05
SmoothMuscle4.15
Spinalcord3.9
SubthalamicNucleus3.35
SuperiorCervicalGanglion4.15
TemporalLobe3.35
Testis293.25
TestisGermCell96.5
TestisIntersitial9.65
TestisLeydigCell93.85
TestisSeminiferousTubule278.9
Thalamus3.7
Thymus2.95
Thyroid4.6
Tongue3.7
Tonsil3.6
Trachea3.05
TrigeminalGanglion3.65
Uterus3
UterusCorpus3.5
WholeBlood4
Wholebrain3.15
colon3.7
pineal_day4.64
pineal_night4.58
retina4.475
small_intestine3.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P236251
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.18 ± 1.21
Basal Forebrain4.48 ± 0.85
Basal Part of Pons3.41 ± 0.82
Cerebellar Cortex4.87 ± 1.11
Cerebellar Nuclei4.69 ± 1.3
Claustrum4.74 ± 1.02
Epithalamus4.55 ± 2.9
Frontal Lobe3.86 ± 1.61
Globus Pallidus6.03 ± 1.5
Hypothalamus5.96 ± 1.9
Insula3.1 ± 1.28
Limbic Lobe3.65 ± 1.08
Mesencephalon4.84 ± 1.65
Myelencephalon4.47 ± 1.45
Occipital Lobe4.77 ± 1.68
Parietal Lobe4.27 ± 1.84
Pontine Tegmentum4.55 ± 1.41
Striatum4.35 ± 1.72
Subthalamus5.14 ± 0.28
Temporal Lobe3.7 ± 1.59
Thalamus4.11 ± 1.15
White Matter3.77 ± 0.82
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dlk1CBCerebellum6.1
9.45
Dlk1CTXCerebral cortex2.27
3.1
Dlk1HIPHippocampal region3.12
6.17
Dlk1HPFHippocampal formation6.15
12.02
Dlk1HYHypothalamus84.76
100
Dlk1LSXLateral septal complex52.93
78.31
Dlk1MBMidbrain26.59
51.76
Dlk1MYMedulla25.92
50.42
Dlk1OLFOlfactory bulb9.95
12.8
Dlk1PPons28.42
51.37
Dlk1PALPallidum38.48
59.11
Dlk1RHPRetrohippocampal region10.43
18.91
Dlk1sAMYStriatum-like amygdalar nuclei45.76
64.66
Dlk1STRStriatum22.35
28.27
Dlk1STRdStriatum dorsal region5.45
6.21
Dlk1STRvStriatum ventral region49.64
54.01
Dlk1THThalamus6.62
8.99
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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