AutismKB 2.0

Annotation Detail for TNFRSF11A


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Basic Information Top
Gene Symbol:TNFRSF11A ( CD265,FEO,LOH18CR1,ODFR,OFE,OPTB7,OSTS,PDB2,RANK,TRANCER )
Gene Full Name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Band: 18q21.33
Quick LinksEntrez ID:8792; OMIM: 603499; Uniprot ID:TNR11_HUMAN; ENSEMBL ID: ENSG00000141655; HGNC ID: 11908
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus4 / 5640127
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult14 / 19391217
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma1 / 8282312
colorectal tumor5 / 11424643
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor0 / 2638450 
glioma1 / 1068839
head and neck tumor3 / 13630222
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor1 / 9635910
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal13 / 33603073
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain3 / 11009892
cervix1 / 4817120
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye0 / 2110540 
heart2 / 8962622
intestine6 / 23447225
kidney3 / 21177714
larynx2 / 2414582
liver1 / 2077434
lung1 / 3369742
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach1 / 9661910
testis0 / 3304420 
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207037_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.45
Adipocyte4.95
AdrenalCortex5.7
Adrenalgland4.4
Amygdala5.2
Appendix7.7
AtrioventricularNode4.05
BDCA4+_DentriticCells5.55
Bonemarrow5.2
BronchialEpithelialCells4.9
CD105+_Endothelial5.05
CD14+_Monocytes5.4
CD19+_BCells(neg._sel.)5.35
CD33+_Myeloid6.5
CD34+6.35
CD4+_Tcells5.45
CD56+_NKCells6.15
CD71+_EarlyErythroid4.75
CD8+_Tcells4.9
CardiacMyocytes7.25
Caudatenucleus4.55
Cerebellum4.15
CerebellumPeduncles5.9
CiliaryGanglion3.8
CingulateCortex5.35
Colorectaladenocarcinoma5.1
DorsalRootGanglion4
FetalThyroid5
Fetalbrain4.9
Fetalliver4.45
Fetallung3.95
GlobusPallidus3.85
Heart6.65
Hypothalamus5.45
Kidney4.25
Leukemia_chronicMyelogenousK-5624.6
Leukemia_promyelocytic-HL-604.55
Leukemialymphoblastic(MOLT-4)4.05
Liver7
Lung5.5
Lymphnode4.35
Lymphoma_burkitts(Daudi)6.65
Lymphoma_burkitts(Raji)7.6
MedullaOblongata4.6
OccipitalLobe4.55
OlfactoryBulb3.95
Ovary3.4
Pancreas4.15
PancreaticIslet6.75
ParietalLobe5.5
Pituitary5.9
Placenta5.15
Pons4.95
PrefrontalCortex6.25
Prostate5.9
Salivarygland4.15
SkeletalMuscle6.5
Skin4
SmoothMuscle5.75
Spinalcord5.45
SubthalamicNucleus4.6
SuperiorCervicalGanglion6.6
TemporalLobe4.75
Testis4.35
TestisGermCell4.2
TestisIntersitial4.3
TestisLeydigCell5.2
TestisSeminiferousTubule4.3
Thalamus5.2
Thymus3.95
Thyroid6.35
Tongue5.25
Tonsil5
Trachea4.3
TrigeminalGanglion6.05
Uterus4.15
UterusCorpus4.85
WholeBlood5.55
Wholebrain4.25
colon6
pineal_day6.3
pineal_night6.18
retina6.2
small_intestine5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P390518
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.65 ± 0.95
Basal Forebrain3.01 ± 0.33
Basal Part of Pons2.94 ± 0.54
Cerebellar Cortex2.98 ± 0.66
Cerebellar Nuclei3.54 ± 0.61
Claustrum3.44 ± 0.7
Epithalamus3.09 ± 0.78
Frontal Lobe3.44 ± 0.74
Globus Pallidus2.92 ± 0.94
Hypothalamus3.16 ± 0.71
Insula3.76 ± 0.42
Limbic Lobe3.32 ± 0.72
Mesencephalon3.35 ± 0.75
Myelencephalon3.44 ± 0.78
Occipital Lobe2.8 ± 1.02
Parietal Lobe3.31 ± 0.75
Pontine Tegmentum3.36 ± 0.78
Striatum2.56 ± 0.81
Subthalamus4.29 ± 2.28
Temporal Lobe3.78 ± 0.68
Thalamus3.44 ± 0.67
White Matter2.78 ± 0.98
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tnfrsf11aCBCerebellum0.92
1.05
Tnfrsf11aCTXCerebral cortex5.36
2.79
Tnfrsf11aHIPHippocampal region0.23
0.31
Tnfrsf11aHPFHippocampal formation0.31
0.45
Tnfrsf11aHYHypothalamus0.16
0.19
Tnfrsf11aLSXLateral septal complex0.11
0.13
Tnfrsf11aMBMidbrain1.02
0.85
Tnfrsf11aMYMedulla0.33
0.27
Tnfrsf11aOLFOlfactory bulb1.31
0.82
Tnfrsf11aPPons0.35
0.31
Tnfrsf11aPALPallidum0.1
0.08
Tnfrsf11aRHPRetrohippocampal region0.43
0.66
Tnfrsf11asAMYStriatum-like amygdalar nuclei0.15
0.13
Tnfrsf11aSTRStriatum0.34
0.24
Tnfrsf11aSTRdStriatum dorsal region0.21
0.18
Tnfrsf11aSTRvStriatum ventral region0.94
0.48
Tnfrsf11aTHThalamus1.89
0.93
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
TNR11_HUMAN_578 10 578 587 RDSFAGNGPR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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