AutismKB 2.0

Annotation Detail for TNFRSF10B


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Basic Information Top
Gene Symbol:TNFRSF10B ( CD262,DR5,KILLER,KILLER/DR5,TRAIL-R2,TRAILR2,TRICK2,TRICK2A,TRICK2B,TRICKB,ZTNFR9 )
Gene Full Name: tumor necrosis factor receptor superfamily, member 10b
Band: 8p21.3
Quick LinksEntrez ID:8795; OMIM: 603612; Uniprot ID:TR10B_HUMAN; ENSEMBL ID: ENSG00000120889; HGNC ID: 11905
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body16 / 70761226
blastocyst14 / 62319224
fetus17 / 56401230
neonate5 / 31097160
infant0 / 236200 
juvenile6 / 55556107
adult278 / 1939121143
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor2 / 3436658
chondrosarcoma6 / 8282372
colorectal tumor101 / 114246884
esophageal tumor0 / 172900 
gastrointestinal tumor8 / 11936967
germ cell tumor75 / 263845284
glioma2 / 10688318
head and neck tumor12 / 13630288
kidney tumor2 / 6895929
leukemia3 / 9584231
liver tumor8 / 9635983
lung tumor9 / 10312787
lymphoma3 / 7175541
non-neoplasia6 / 9725061
normal187 / 336030755
ovarian tumor13 / 76682169
pancreatic tumor14 / 104616133
primitive neuroectodermal tumor of the CNS10 / 12568079
prostate cancer22 / 102680214
retinoblastoma8 / 46356172
skin tumor4 / 12494932
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor10 / 90257110
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites1 / 4001524
bladder0 / 297570 
blood5 / 12347840
bone0 / 716550 
bone marrow1 / 4880120
brain36 / 110098932
cervix4 / 4817183
connective tissue10 / 14925566
ear0 / 162120 
embryonic tissue38 / 215722176
esophagus0 / 202090 
eye18 / 21105485
heart0 / 896260 
intestine105 / 234472447
kidney8 / 21177737
larynx1 / 2414541
liver10 / 20774348
lung20 / 33697459
lymph1 / 4427022
lymph node2 / 9161021
mammary gland8 / 15327152
mouth7 / 67052104
muscle14 / 107715129
nerve0 / 157680 
ovary15 / 102051146
pancreas14 / 21481265
parathyroid1 / 2053948
pharynx3 / 4132872
pituitary gland0 / 165850 
placenta4 / 28082514
prostate33 / 189345174
salivary gland0 / 201550 
skin9 / 21057442
spleen7 / 53952129
stomach13 / 96619134
testis70 / 330442211
thymus7 / 8113186
thyroid2 / 4747342
tonsil0 / 169990 
trachea10 / 52413190
umbilical cord2 / 13680146
uterus20 / 23287885
vascular8 / 51780154
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210405_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts46.5
Adipocyte3.9
AdrenalCortex4.05
Adrenalgland3.15
Amygdala3.85
Appendix3.95
AtrioventricularNode2.95
BDCA4+_DentriticCells4.35
Bonemarrow3.75
BronchialEpithelialCells12.95
CD105+_Endothelial3.8
CD14+_Monocytes5
CD19+_BCells(neg._sel.)4.3
CD33+_Myeloid22.75
CD34+4.95
CD4+_Tcells4.2
CD56+_NKCells4.6
CD71+_EarlyErythroid3.5
CD8+_Tcells3.7
CardiacMyocytes47.95
Caudatenucleus3.35
Cerebellum3.05
CerebellumPeduncles4.25
CiliaryGanglion2.75
CingulateCortex3.85
Colorectaladenocarcinoma5.05
DorsalRootGanglion2.85
FetalThyroid3.65
Fetalbrain3.75
Fetalliver3.9
Fetallung4.7
GlobusPallidus2.7
Heart4.8
Hypothalamus4.05
Kidney3.05
Leukemia_chronicMyelogenousK-5623.45
Leukemia_promyelocytic-HL-604.5
Leukemialymphoblastic(MOLT-4)3
Liver5
Lung8.05
Lymphnode3.25
Lymphoma_burkitts(Daudi)4.8
Lymphoma_burkitts(Raji)7.5
MedullaOblongata3.4
OccipitalLobe3.35
OlfactoryBulb4.05
Ovary2.5
Pancreas3.1
PancreaticIslet4
ParietalLobe4
Pituitary4.4
Placenta5.45
Pons3.6
PrefrontalCortex4.7
Prostate4.5
Salivarygland3.05
SkeletalMuscle5.3
Skin2.85
SmoothMuscle31
Spinalcord4.05
SubthalamicNucleus3.45
SuperiorCervicalGanglion5.2
TemporalLobe3.45
Testis3.2
TestisGermCell3.1
TestisIntersitial3.15
TestisLeydigCell3.75
TestisSeminiferousTubule3.25
Thalamus3.85
Thymus3
Thyroid4.7
Tongue3.7
Tonsil3.7
Trachea3.15
TrigeminalGanglion3.7
Uterus3.65
UterusCorpus5.5
WholeBlood4.2
Wholebrain3.2
colon3.8
pineal_day4.7
pineal_night4.58
retina4.6
small_intestine3.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P169030
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.53 ± 0.88
Basal Forebrain2.95 ± 0.62
Basal Part of Pons3.36 ± 0.73
Cerebellar Cortex2.92 ± 0.55
Cerebellar Nuclei3.5 ± 0.67
Claustrum3.44 ± 0.75
Epithalamus4.68 ± 0.98
Frontal Lobe3.47 ± 0.84
Globus Pallidus4.65 ± 0.82
Hypothalamus2.89 ± 0.8
Insula3.23 ± 0.68
Limbic Lobe3.85 ± 0.93
Mesencephalon3.5 ± 0.68
Myelencephalon3.55 ± 0.86
Occipital Lobe3.37 ± 1.01
Parietal Lobe3.61 ± 0.72
Pontine Tegmentum3.59 ± 0.93
Striatum3.41 ± 0.93
Subthalamus3.3 ± 0.9
Temporal Lobe3.64 ± 0.77
Thalamus3.24 ± 0.66
White Matter3.64 ± 0.95
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tnfrsf10bCBCerebellum9.62
11.56
Tnfrsf10bCTXCerebral cortex19.54
14.8
Tnfrsf10bHIPHippocampal region13.78
15.07
Tnfrsf10bHPFHippocampal formation17.41
15.38
Tnfrsf10bHYHypothalamus10.52
7.31
Tnfrsf10bLSXLateral septal complex10.51
6.47
Tnfrsf10bMBMidbrain11.39
9.29
Tnfrsf10bMYMedulla15.46
14.22
Tnfrsf10bOLFOlfactory bulb35.08
25.61
Tnfrsf10bPPons13.48
12.19
Tnfrsf10bPALPallidum8.88
6.68
Tnfrsf10bRHPRetrohippocampal region24.49
16.54
Tnfrsf10bsAMYStriatum-like amygdalar nuclei4.37
2.65
Tnfrsf10bSTRStriatum12.19
7.84
Tnfrsf10bSTRdStriatum dorsal region12.9
8.73
Tnfrsf10bSTRvStriatum ventral region16.61
9.33
Tnfrsf10bTHThalamus14.3
11.52
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00039622 15 119 133 CDSGEVELSPCTTTR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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