AutismKB 2.0

Annotation Detail for SUCLA2


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Basic Information Top
Gene Symbol:SUCLA2 ( A-BETA,SCS-betaA )
Gene Full Name: succinate-CoA ligase, ADP-forming, beta subunit
Band: 13q14.2
Quick LinksEntrez ID:8803; OMIM: 603921; Uniprot ID:SUCB1_HUMAN; ENSEMBL ID: ENSG00000136143; HGNC ID: 11448
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus2 / 5640123
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult14 / 19391217
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma2 / 10688318
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal17 / 33603075
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain8 / 11009897
cervix0 / 481710 
connective tissue0 / 1492550 
ear1 / 1621261
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye6 / 21105428
heart0 / 896260 
intestine0 / 2344720 
kidney1 / 2117774
larynx0 / 241450 
liver0 / 2077430 
lung2 / 3369745
lymph0 / 442700 
lymph node0 / 916100 
mammary gland2 / 15327113
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate2 / 18934510
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach1 / 9661910
testis3 / 3304429
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202930_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts147
Adipocyte29
AdrenalCortex13.5
Adrenalgland14.15
Amygdala228.55
Appendix19.9
AtrioventricularNode10.6
BDCA4+_DentriticCells35.35
Bonemarrow11.3
BronchialEpithelialCells54.85
CD105+_Endothelial33.25
CD14+_Monocytes28.2
CD19+_BCells(neg._sel.)17.35
CD33+_Myeloid24
CD34+48.95
CD4+_Tcells15.3
CD56+_NKCells21.8
CD71+_EarlyErythroid11.15
CD8+_Tcells15.55
CardiacMyocytes21.5
Caudatenucleus69.2
Cerebellum20.8
CerebellumPeduncles31.7
CiliaryGanglion12.75
CingulateCortex63.55
Colorectaladenocarcinoma45.4
DorsalRootGanglion17.25
FetalThyroid20.2
Fetalbrain63
Fetalliver19.9
Fetallung18.45
GlobusPallidus46.5
Heart14.8
Hypothalamus157.5
Kidney13.95
Leukemia_chronicMyelogenousK-56220.05
Leukemia_promyelocytic-HL-6083.4
Leukemialymphoblastic(MOLT-4)17.45
Liver12.95
Lung10.2
Lymphnode12.75
Lymphoma_burkitts(Daudi)42.05
Lymphoma_burkitts(Raji)31.5
MedullaOblongata72.15
OccipitalLobe133.4
OlfactoryBulb22.35
Ovary8.25
Pancreas58.35
PancreaticIslet24.5
ParietalLobe71.15
Pituitary55.7
Placenta9.8
Pons19.35
PrefrontalCortex116.55
Prostate21.25
Salivarygland14.95
SkeletalMuscle20
Skin14.1
SmoothMuscle28.25
Spinalcord70.1
SubthalamicNucleus80.75
SuperiorCervicalGanglion17.75
TemporalLobe48.1
Testis7.45
TestisGermCell12.05
TestisIntersitial15.05
TestisLeydigCell12
TestisSeminiferousTubule9.85
Thalamus69.35
Thymus8.3
Thyroid183.2
Tongue53.95
Tonsil14.25
Trachea15.45
TrigeminalGanglion16.35
Uterus67.05
UterusCorpus11.1
WholeBlood20.55
Wholebrain132.3
colon54.5
pineal_day217.28
pineal_night222
retina25.825
small_intestine27.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P181275
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.36 ± 0.31
Basal Forebrain8.1 ± 0.3
Basal Part of Pons8.32 ± 0.37
Cerebellar Cortex8 ± 0.43
Cerebellar Nuclei8.87 ± 0.39
Claustrum8.66 ± 0.5
Epithalamus7.75 ± 0.62
Frontal Lobe8.31 ± 0.46
Globus Pallidus8.53 ± 0.32
Hypothalamus8.09 ± 0.32
Insula8.16 ± 0.33
Limbic Lobe8.4 ± 0.4
Mesencephalon8.41 ± 0.52
Myelencephalon8.26 ± 0.43
Occipital Lobe8.56 ± 0.42
Parietal Lobe8.4 ± 0.43
Pontine Tegmentum8.31 ± 0.4
Striatum8.04 ± 0.43
Subthalamus8.67 ± 0.22
Temporal Lobe8.17 ± 0.42
Thalamus8.41 ± 0.34
White Matter8.03 ± 0.28
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Sucla2CBCerebellum42.14
100
Sucla2CTXCerebral cortex100
100
Sucla2HIPHippocampal region100
100
Sucla2HPFHippocampal formation100
100
Sucla2HYHypothalamus100
100
Sucla2LSXLateral septal complex100
100
Sucla2MBMidbrain100
100
Sucla2MYMedulla100
100
Sucla2OLFOlfactory bulb98
100
Sucla2PPons97.88
100
Sucla2PALPallidum100
100
Sucla2RHPRetrohippocampal region100
100
Sucla2sAMYStriatum-like amygdalar nuclei100
100
Sucla2STRStriatum100
100
Sucla2STRdStriatum dorsal region100
100
Sucla2STRvStriatum ventral region100
100
Sucla2THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00003905 12 427 438 ILACDDLDEAAR Peptide Atlas
SUCB1_HUMAN_0 0 0 0 LHGGTPANFLDVGGGATVHQVTEAFK PRIDE
SUCB1_HUMAN_217 9 217 225 EQALQLAQK PRIDE
SUCB1_HUMAN_275 10 275 284 INFDSNSAYR PRIDE
SUCB1_HUMAN_427 12 427 438 ILACDDLDEAAR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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