AutismKB 2.0

Annotation Detail for SOCS2


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Basic Information Top
Gene Symbol:SOCS2 ( CIS2,Cish2,SOCS-2,SSI-2,SSI2,STATI2 )
Gene Full Name: suppressor of cytokine signaling 2
Band: 12q
Quick LinksEntrez ID:8835; OMIM: 605117; Uniprot ID:SOCS2_HUMAN; ENSEMBL ID: ENSG00000120833; HGNC ID: 19382
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst0 / 623190 
fetus44 / 56401278
neonate1 / 3109732
infant0 / 236200 
juvenile1 / 5555617
adult116 / 193912159
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor1 / 9417810
cervical tumor1 / 3436629
chondrosarcoma3 / 8282336
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor16 / 26384560
glioma0 / 1068830 
head and neck tumor1 / 1363027
kidney tumor1 / 6895914
leukemia6 / 9584262
liver tumor11 / 96359114
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia4 / 9725041
normal184 / 336030754
ovarian tumor2 / 7668226
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer14 / 102680136
retinoblastoma1 / 4635621
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland0 / 331970 
ascites1 / 4001524
bladder4 / 29757134
blood5 / 12347840
bone3 / 7165541
bone marrow8 / 48801163
brain30 / 110098927
cervix4 / 4817183
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye1 / 2110544
heart7 / 8962678
intestine6 / 23447225
kidney15 / 21177770
larynx0 / 241450 
liver17 / 20774381
lung23 / 33697468
lymph0 / 442700 
lymph node2 / 9161021
mammary gland4 / 15327126
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary2 / 10205119
pancreas13 / 21481260
parathyroid7 / 20539340
pharynx3 / 4132872
pituitary gland0 / 165850 
placenta27 / 28082596
prostate23 / 189345121
salivary gland1 / 2015549
skin1 / 2105744
spleen0 / 539520 
stomach1 / 9661910
testis10 / 33044230
thymus3 / 8113136
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord1 / 1368073
uterus17 / 23287872
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203373_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.1
Adipocyte5.95
AdrenalCortex12.7
Adrenalgland13.45
Amygdala5.85
Appendix12.9
AtrioventricularNode5.15
BDCA4+_DentriticCells5.5
Bonemarrow6.15
BronchialEpithelialCells6.25
CD105+_Endothelial90.4
CD14+_Monocytes5.8
CD19+_BCells(neg._sel.)5.8
CD33+_Myeloid7.55
CD34+183.95
CD4+_Tcells7.8
CD56+_NKCells20.85
CD71+_EarlyErythroid5.8
CD8+_Tcells9.65
CardiacMyocytes7.9
Caudatenucleus5.1
Cerebellum4.9
CerebellumPeduncles6.65
CiliaryGanglion4.75
CingulateCortex6.45
Colorectaladenocarcinoma7.55
DorsalRootGanglion5.5
FetalThyroid9.5
Fetalbrain11.8
Fetalliver13.75
Fetallung8
GlobusPallidus4.6
Heart7.9
Hypothalamus5.75
Kidney5.65
Leukemia_chronicMyelogenousK-562288.35
Leukemia_promyelocytic-HL-604.85
Leukemialymphoblastic(MOLT-4)4.35
Liver10.45
Lung41.05
Lymphnode7.8
Lymphoma_burkitts(Daudi)7.45
Lymphoma_burkitts(Raji)8.1
MedullaOblongata5.75
OccipitalLobe5.45
OlfactoryBulb11.7
Ovary4.9
Pancreas4.9
PancreaticIslet38.6
ParietalLobe6.25
Pituitary56.25
Placenta26.55
Pons6.65
PrefrontalCortex6.7
Prostate129.05
Salivarygland5.35
SkeletalMuscle11.35
Skin8.1
SmoothMuscle6.1
Spinalcord6.4
SubthalamicNucleus5.9
SuperiorCervicalGanglion8.55
TemporalLobe6.15
Testis6.25
TestisGermCell5.3
TestisIntersitial5.4
TestisLeydigCell6.7
TestisSeminiferousTubule5.5
Thalamus6.25
Thymus5.85
Thyroid11.45
Tongue6
Tonsil5.5
Trachea7.5
TrigeminalGanglion8.3
Uterus196.75
UterusCorpus39.4
WholeBlood6.7
Wholebrain5.3
colon26.8
pineal_day9.84
pineal_night8.5
retina18.05
small_intestine27.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P230675
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.95 ± 0.6
Basal Forebrain4.5 ± 0.49
Basal Part of Pons4.99 ± 0.57
Cerebellar Cortex4.62 ± 0.69
Cerebellar Nuclei4.89 ± 0.47
Claustrum6.23 ± 0.77
Epithalamus5.06 ± 0.45
Frontal Lobe4.94 ± 0.55
Globus Pallidus4.75 ± 0.89
Hypothalamus4.3 ± 0.49
Insula4.86 ± 0.34
Limbic Lobe5.38 ± 0.74
Mesencephalon4.96 ± 0.6
Myelencephalon4.99 ± 0.65
Occipital Lobe5.48 ± 0.78
Parietal Lobe4.92 ± 0.6
Pontine Tegmentum4.84 ± 0.81
Striatum4.91 ± 0.69
Subthalamus4.69 ± 0.76
Temporal Lobe4.99 ± 0.58
Thalamus4.74 ± 0.44
White Matter3.09 ± 0.63
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Socs2CBCerebellum43.64
38.43
Socs2CTXCerebral cortex50.42
36.72
Socs2HIPHippocampal region24.3
34.14
Socs2HPFHippocampal formation38.02
43.13
Socs2HYHypothalamus7.7
10.82
Socs2LSXLateral septal complex10.33
6.7
Socs2MBMidbrain8.77
9.44
Socs2MYMedulla16.38
16.86
Socs2OLFOlfactory bulb38.72
30.43
Socs2PPons12.8
13.47
Socs2PALPallidum10.22
8.92
Socs2RHPRetrohippocampal region62.58
57.49
Socs2sAMYStriatum-like amygdalar nuclei25.29
22.59
Socs2STRStriatum16.51
12.51
Socs2STRdStriatum dorsal region16.8
12.55
Socs2STRvStriatum ventral region13.66
9.71
Socs2THThalamus37.34
35.03
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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