AutismKB 2.0

Annotation Detail for CFLAR


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Basic Information Top
Gene Symbol:CFLAR ( CASH,CASP8AP1,CLARP,Casper,FLAME,FLAME-1,FLAME1,FLIP,I-FLICE,MRIT,c-FLIP,c-FLIPL,c-FLIPR,c-FLIPS )
Gene Full Name: CASP8 and FADD-like apoptosis regulator
Band: 2q33.1
Quick LinksEntrez ID:8837; OMIM: 603599; Uniprot ID:CFLAR_HUMAN; ENSEMBL ID: ENSG00000003402; HGNC ID: 1876
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst1 / 6231916
fetus38 / 56401267
neonate5 / 31097160
infant1 / 2362042
juvenile5 / 5555689
adult264 / 1939121136
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor1 / 9417810
cervical tumor1 / 3436629
chondrosarcoma5 / 8282360
colorectal tumor21 / 114246183
esophageal tumor1 / 1729057
gastrointestinal tumor19 / 119369159
germ cell tumor9 / 26384534
glioma2 / 10688318
head and neck tumor28 / 136302205
kidney tumor2 / 6895929
leukemia10 / 95842104
liver tumor14 / 96359145
lung tumor7 / 10312767
lymphoma16 / 71755222
non-neoplasia4 / 9725041
normal309 / 336030791
ovarian tumor1 / 7668213
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS6 / 12568047
prostate cancer3 / 10268029
retinoblastoma1 / 4635621
skin tumor3 / 12494924
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor16 / 90257177
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland2 / 3319760
ascites1 / 4001524
bladder5 / 29757168
blood45 / 123478364
bone1 / 7165513
bone marrow3 / 4880161
brain98 / 110098989
cervix1 / 4817120
connective tissue10 / 14925566
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus1 / 2020949
eye2 / 2110549
heart6 / 8962666
intestine41 / 234472174
kidney13 / 21177761
larynx14 / 24145579
liver28 / 207743134
lung59 / 336974175
lymph16 / 44270361
lymph node5 / 9161054
mammary gland20 / 153271130
mouth10 / 67052149
muscle2 / 10771518
nerve1 / 1576863
ovary3 / 10205129
pancreas15 / 21481269
parathyroid0 / 205390 
pharynx6 / 41328145
pituitary gland0 / 165850 
placenta24 / 28082585
prostate8 / 18934542
salivary gland0 / 201550 
skin10 / 21057447
spleen14 / 53952259
stomach17 / 96619175
testis4 / 33044212
thymus13 / 81131160
thyroid4 / 4747384
tonsil1 / 1699958
trachea6 / 52413114
umbilical cord3 / 13680219
uterus29 / 232878124
vascular8 / 51780154
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211316_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts166.8
Adipocyte116.05
AdrenalCortex171.9
Adrenalgland113.25
Amygdala136.15
Appendix136.4
AtrioventricularNode101.75
BDCA4+_DentriticCells283.1
Bonemarrow183.5
BronchialEpithelialCells76.8
CD105+_Endothelial144.2
CD14+_Monocytes292.35
CD19+_BCells(neg._sel.)146.7
CD33+_Myeloid671.9
CD34+277.35
CD4+_Tcells497.9
CD56+_NKCells612.5
CD71+_EarlyErythroid95.4
CD8+_Tcells371.7
CardiacMyocytes150.3
Caudatenucleus79.2
Cerebellum97.65
CerebellumPeduncles138.7
CiliaryGanglion94.3
CingulateCortex124
Colorectaladenocarcinoma103.35
DorsalRootGanglion113.4
FetalThyroid133.55
Fetalbrain126.8
Fetalliver103.75
Fetallung160.4
GlobusPallidus86.95
Heart141.85
Hypothalamus95.85
Kidney98.85
Leukemia_chronicMyelogenousK-562126.1
Leukemia_promyelocytic-HL-6082.05
Leukemialymphoblastic(MOLT-4)55.5
Liver151.9
Lung553.7
Lymphnode195.95
Lymphoma_burkitts(Daudi)116.1
Lymphoma_burkitts(Raji)189.75
MedullaOblongata110.3
OccipitalLobe108.45
OlfactoryBulb138.15
Ovary79.1
Pancreas126.55
PancreaticIslet154.85
ParietalLobe136.55
Pituitary144.7
Placenta202.85
Pons120.9
PrefrontalCortex222.35
Prostate307.4
Salivarygland96.45
SkeletalMuscle152
Skin152.4
SmoothMuscle78.65
Spinalcord78.7
SubthalamicNucleus113.25
SuperiorCervicalGanglion200
TemporalLobe89.75
Testis96.75
TestisGermCell112.05
TestisIntersitial107.95
TestisLeydigCell111.1
TestisSeminiferousTubule109.25
Thalamus66.25
Thymus243.05
Thyroid211.1
Tongue146.75
Tonsil203.15
Trachea115.15
TrigeminalGanglion132.7
Uterus252.3
UterusCorpus113.3
WholeBlood331.8
Wholebrain65.25
colon187.9
pineal_day205.24
pineal_night234.78
retina162.425
small_intestine180.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P209394
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.6 ± 0.4
Basal Forebrain6.53 ± 0.18
Basal Part of Pons6.53 ± 0.34
Cerebellar Cortex6.9 ± 0.17
Cerebellar Nuclei6.69 ± 0.39
Claustrum6.69 ± 0.39
Epithalamus6.85 ± 0.36
Frontal Lobe6.25 ± 0.46
Globus Pallidus7.13 ± 0.49
Hypothalamus6.32 ± 0.45
Insula6.49 ± 0.33
Limbic Lobe6.61 ± 0.53
Mesencephalon6.52 ± 0.47
Myelencephalon6.5 ± 0.41
Occipital Lobe6.67 ± 0.4
Parietal Lobe6.29 ± 0.48
Pontine Tegmentum6.55 ± 0.42
Striatum6.76 ± 0.58
Subthalamus6.51 ± 0.32
Temporal Lobe6.46 ± 0.39
Thalamus6.4 ± 0.35
White Matter7.72 ± 0.4
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
CflarCBCerebellum22.62
31
CflarCTXCerebral cortex11.65
12.83
CflarHIPHippocampal region14.42
15.95
CflarHPFHippocampal formation10.74
11.12
CflarHYHypothalamus3.78
3.42
CflarLSXLateral septal complex2.17
2.02
CflarMBMidbrain4.11
5.48
CflarMYMedulla10.66
12.36
CflarOLFOlfactory bulb10.2
8.53
CflarPPons5.64
11.54
CflarPALPallidum0.95
0.97
CflarRHPRetrohippocampal region2.17
2.1
CflarsAMYStriatum-like amygdalar nuclei2.46
4.87
CflarSTRStriatum2.43
3.24
CflarSTRdStriatum dorsal region2.92
3.85
CflarSTRvStriatum ventral region1.03
1.13
CflarTHThalamus4.14
5.35
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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