Annotation Detail for HDAC3
Basic Information Top
| Gene Symbol: | HDAC3 ( HD3,RPD3,RPD3-2 ) |
|---|---|
| Gene Full Name: | histone deacetylase 3 |
| Band: | 5q31.3 |
| Quick Links | Entrez ID:8841; OMIM: 605166; Uniprot ID:HDAC3_HUMAN; ENSEMBL ID: ENSG00000171720; HGNC ID: 4854 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.519632
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 6 / 70761 | 84 |  |
| blastocyst | 9 / 62319 | 144 | |
| fetus | 34 / 564012 | 60 | |
| neonate | 0 / 31097 | 0 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 2 / 55556 | 35 |  |
| adult | 110 / 1939121 | 56 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 1 / 12794 | 78 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 3 / 94178 | 31 | |
| cervical tumor | 1 / 34366 | 29 | |
| chondrosarcoma | 8 / 82823 | 96 | |
| colorectal tumor | 9 / 114246 | 78 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 8 / 119369 | 67 | |
| germ cell tumor | 9 / 263845 | 34 | |
| glioma | 8 / 106883 | 74 | |
| head and neck tumor | 3 / 136302 | 22 | |
| kidney tumor | 3 / 68959 | 43 | |
| leukemia | 10 / 95842 | 104 | |
| liver tumor | 4 / 96359 | 41 | |
| lung tumor | 10 / 103127 | 96 | |
| lymphoma | 3 / 71755 | 41 | |
| non-neoplasia | 1 / 97250 | 10 |  |
| normal | 157 / 3360307 | 46 | |
| ovarian tumor | 5 / 76682 | 65 | |
| pancreatic tumor | 10 / 104616 | 95 | |
| primitive neuroectodermal tumor of the CNS | 15 / 125680 | 119 | |
| prostate cancer | 5 / 102680 | 48 | |
| retinoblastoma | 1 / 46356 | 21 | |
| skin tumor | 18 / 124949 | 144 | |
| soft tissue/muscle tissue tumor | 10 / 125191 | 79 | |
| uterine tumor | 3 / 90257 | 33 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 1 / 13106 | 76 | |
| adrenal gland | 1 / 33197 | 30 | |
| ascites | 1 / 40015 | 24 | |
| bladder | 1 / 29757 | 33 | |
| blood | 12 / 123478 | 97 | |
| bone | 4 / 71655 | 55 | |
| bone marrow | 0 / 48801 | 0 | |
| brain | 27 / 1100989 | 24 | |
| cervix | 7 / 48171 | 145 | |
| connective tissue | 3 / 149255 | 20 | |
| ear | 1 / 16212 | 61 | |
| embryonic tissue | 23 / 215722 | 106 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 11 / 211054 | 52 | |
| heart | 3 / 89626 | 33 | |
| intestine | 13 / 234472 | 55 | |
| kidney | 7 / 211777 | 33 | |
| larynx | 0 / 24145 | 0 | |
| liver | 8 / 207743 | 38 | |
| lung | 28 / 336974 | 83 | |
| lymph | 3 / 44270 | 67 | |
| lymph node | 7 / 91610 | 76 | |
| mammary gland | 5 / 153271 | 32 | |
| mouth | 0 / 67052 | 0 | |
| muscle | 9 / 107715 | 83 | |
| nerve | 1 / 15768 | 63 | |
| ovary | 12 / 102051 | 117 | |
| pancreas | 17 / 214812 | 79 | |
| parathyroid | 1 / 20539 | 48 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 14 / 280825 | 49 | |
| prostate | 8 / 189345 | 42 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 18 / 210574 | 85 | |
| spleen | 1 / 53952 | 18 | |
| stomach | 7 / 96619 | 72 | |
| testis | 12 / 330442 | 36 | |
| thymus | 0 / 81131 | 0 | |
| thyroid | 3 / 47473 | 63 | |
| tonsil | 3 / 16999 | 176 | |
| trachea | 0 / 52413 | 0 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 12 / 232878 | 51 | |
| vascular | 0 / 51780 | 0 |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 216326_s_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 250.65 |  |
| Adipocyte | 28.25 | |
| AdrenalCortex | 35.35 | |
| Adrenalgland | 28.55 | |
| Amygdala | 23.65 | |
| Appendix | 33.4 | |
| AtrioventricularNode | 27.15 | |
| BDCA4+_DentriticCells | 69.25 | |
| Bonemarrow | 50.4 | |
| BronchialEpithelialCells | 56.1 | |
| CD105+_Endothelial | 133.15 | |
| CD14+_Monocytes | 35.8 | |
| CD19+_BCells(neg._sel.) | 100.4 | |
| CD33+_Myeloid | 89.35 | |
| CD34+ | 79.25 | |
| CD4+_Tcells | 49.8 | |
| CD56+_NKCells | 42.6 | |
| CD71+_EarlyErythroid | 101.6 | |
| CD8+_Tcells | 99.55 | |
| CardiacMyocytes | 33.7 | |
| Caudatenucleus | 29.8 | |
| Cerebellum | 26.55 | |
| CerebellumPeduncles | 38.3 | |
| CiliaryGanglion | 24.7 | |
| CingulateCortex | 33.95 | |
| Colorectaladenocarcinoma | 33.5 | |
| DorsalRootGanglion | 24 | |
| FetalThyroid | 34.1 | |
| Fetalbrain | 40.35 | |
| Fetalliver | 28.7 | |
| Fetallung | 31.75 | |
| GlobusPallidus | 27.85 | |
| Heart | 35.75 | |
| Hypothalamus | 35.1 | |
| Kidney | 28.2 | |
| Leukemia_chronicMyelogenousK-562 | 37.35 | |
| Leukemia_promyelocytic-HL-60 | 34.2 | |
| Leukemialymphoblastic(MOLT-4) | 46.85 | |
| Liver | 41.4 | |
| Lung | 38.4 | |
| Lymphnode | 42.45 | |
| Lymphoma_burkitts(Daudi) | 50.95 | |
| Lymphoma_burkitts(Raji) | 59.05 | |
| MedullaOblongata | 29.25 | |
| OccipitalLobe | 28.8 | |
| OlfactoryBulb | 27.9 | |
| Ovary | 21.9 | |
| Pancreas | 26.65 | |
| PancreaticIslet | 35.6 | |
| ParietalLobe | 34.25 | |
| Pituitary | 42.3 | |
| Placenta | 42.4 | |
| Pons | 29.55 | |
| PrefrontalCortex | 40.85 | |
| Prostate | 38.35 | |
| Salivarygland | 27.85 | |
| SkeletalMuscle | 37.75 | |
| Skin | 26.85 | |
| SmoothMuscle | 37.45 | |
| Spinalcord | 35.3 | |
| SubthalamicNucleus | 29.55 | |
| SuperiorCervicalGanglion | 42.6 | |
| TemporalLobe | 29.45 | |
| Testis | 30 | |
| TestisGermCell | 27.25 | |
| TestisIntersitial | 28 | |
| TestisLeydigCell | 33.2 | |
| TestisSeminiferousTubule | 27.5 | |
| Thalamus | 29.6 | |
| Thymus | 39.55 | |
| Thyroid | 55.8 | |
| Tongue | 33.55 | |
| Tonsil | 34.15 | |
| Trachea | 27.6 | |
| TrigeminalGanglion | 38.5 | |
| Uterus | 28.3 | |
| UterusCorpus | 30.95 | |
| WholeBlood | 31.3 | |
| Wholebrain | 26.05 | |
| colon | 36.9 | |
| pineal_day | 40.68 | |
| pineal_night | 41.46 | |
| retina | 42.425 | |
| small_intestine | 38.6 | |
- Probe name: CUST_14406_PI416261804
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 7.3 ± 0.53 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 7.25 ± 0.54 | |
| Basal Part of Pons | 7.12 ± 0.3 | |
| Cerebellar Cortex | 7.28 ± 0.37 | |
| Cerebellar Nuclei | 7.17 ± 0.52 | |
| Claustrum | 7.69 ± 0.57 | |
| Epithalamus | 6.79 ± 0.33 | |
| Frontal Lobe | 7.09 ± 0.45 | |
| Globus Pallidus | 7.26 ± 0.53 | |
| Hypothalamus | 6.97 ± 0.41 | |
| Insula | 7.02 ± 0.36 | |
| Limbic Lobe | 7.23 ± 0.49 | |
| Mesencephalon | 7.1 ± 0.42 | |
| Myelencephalon | 7.16 ± 0.48 | |
| Occipital Lobe | 7.27 ± 0.44 | |
| Parietal Lobe | 7.09 ± 0.41 | |
| Pontine Tegmentum | 7.1 ± 0.43 | |
| Striatum | 6.98 ± 0.46 | |
| Subthalamus | 7.09 ± 0.14 | |
| Temporal Lobe | 7.13 ± 0.48 | |
| Thalamus | 7.1 ± 0.41 | |
| White Matter | 7.46 ± 0.58 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Hdac3 | CB | Cerebellum | 38.21 | |
| 49.89 | | |||
| Hdac3 | CTX | Cerebral cortex | 100 | |
| 99.51 | | |||
| Hdac3 | HIP | Hippocampal region | 57.77 | |
| 97.89 | | |||
| Hdac3 | HPF | Hippocampal formation | 74.05 | |
| 98.56 | | |||
| Hdac3 | HY | Hypothalamus | 100 | |
| 100 | | |||
| Hdac3 | LSX | Lateral septal complex | 100 | |
| 81.72 | | |||
| Hdac3 | MB | Midbrain | 99.27 | |
| 99.73 | | |||
| Hdac3 | MY | Medulla | 90.94 | |
| 100 | | |||
| Hdac3 | OLF | Olfactory bulb | 95.6 | |
| 89.23 | | |||
| Hdac3 | P | Pons | 91.44 | |
| 100 | | |||
| Hdac3 | PAL | Pallidum | 100 | |
| 100 | | |||
| Hdac3 | RHP | Retrohippocampal region | 100 | |
| 100 | | |||
| Hdac3 | sAMY | Striatum-like amygdalar nuclei | 100 | |
| 100 | | |||
| Hdac3 | STR | Striatum | 64.29 | |
| 50.87 | | |||
| Hdac3 | STRd | Striatum dorsal region | 47.85 | |
| 37.63 | | |||
| Hdac3 | STRv | Striatum ventral region | 74.53 | |
| 56.06 | | |||
| Hdac3 | TH | Thalamus | 79.17 | |
| 71.46 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| HDAC3_HUMAN_187 | 8 | 187 | 194 | VMTVSFHK | PRIDE |
| PAp00074811 | 22 | 368 | 389 | MLNHAPSVQIHDVPADLLTYDR | Peptide Atlas |