AutismKB 2.0

Annotation Detail for CDK5R1


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Basic Information Top
Gene Symbol:CDK5R1 ( CDK5P35,CDK5R,MGC33831,NCK5A,p23,p25,p35,p35nck5a )
Gene Full Name: cyclin-dependent kinase 5, regulatory subunit 1 (p35)
Band: 17q11.2
Quick LinksEntrez ID:8851; OMIM: 603460; Uniprot ID:CD5R1_HUMAN; ENSEMBL ID: ENSG00000176749; HGNC ID: 1775
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus101 / 564012179
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult17 / 19391218
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor7 / 26384526
glioma3 / 10688328
head and neck tumor2 / 13630214
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor1 / 9635910
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal212 / 336030763
ovarian tumor0 / 766820 
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer2 / 10268019
retinoblastoma2 / 4635643
skin tumor6 / 12494948
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain202 / 1100989183
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye9 / 21105442
heart0 / 896260 
intestine1 / 2344724
kidney2 / 2117779
larynx0 / 241450 
liver1 / 2077434
lung4 / 33697411
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth2 / 6705229
muscle1 / 1077159
nerve0 / 157680 
ovary2 / 10205119
pancreas5 / 21481223
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate2 / 18934510
salivary gland0 / 201550 
skin11 / 21057452
spleen1 / 5395218
stomach0 / 966190 
testis4 / 33044212
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204996_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts3.8
Adipocyte2.95
AdrenalCortex3.05
Adrenalgland2.45
Amygdala3.2
Appendix3
AtrioventricularNode2.25
BDCA4+_DentriticCells3.35
Bonemarrow2.9
BronchialEpithelialCells2.95
CD105+_Endothelial3
CD14+_Monocytes3.2
CD19+_BCells(neg._sel.)3.2
CD33+_Myeloid3.9
CD34+3.85
CD4+_Tcells3.3
CD56+_NKCells3.65
CD71+_EarlyErythroid2.85
CD8+_Tcells2.95
CardiacMyocytes3.75
Caudatenucleus2.65
Cerebellum2.4
CerebellumPeduncles3.35
CiliaryGanglion2.05
CingulateCortex3
Colorectaladenocarcinoma3
DorsalRootGanglion2.25
FetalThyroid2.85
Fetalbrain3
Fetalliver2.55
Fetallung2.5
GlobusPallidus2.15
Heart3.75
Hypothalamus3.3
Kidney2.4
Leukemia_chronicMyelogenousK-5622.65
Leukemia_promyelocytic-HL-602.6
Leukemialymphoblastic(MOLT-4)2.45
Liver3.85
Lung3.3
Lymphnode2.6
Lymphoma_burkitts(Daudi)3.75
Lymphoma_burkitts(Raji)4.1
MedullaOblongata2.75
OccipitalLobe2.65
OlfactoryBulb2.35
Ovary1.95
Pancreas2.35
PancreaticIslet3.15
ParietalLobe3.1
Pituitary3.5
Placenta3.15
Pons2.8
PrefrontalCortex3.75
Prostate3.5
Salivarygland2.4
SkeletalMuscle3.4
Skin2.25
SmoothMuscle3.4
Spinalcord3.15
SubthalamicNucleus2.7
SuperiorCervicalGanglion3.35
TemporalLobe2.7
Testis2.6
TestisGermCell2.5
TestisIntersitial2.5
TestisLeydigCell2.9
TestisSeminiferousTubule2.55
Thalamus3
Thymus2.35
Thyroid3.75
Tongue2.85
Tonsil2.9
Trachea2.5
TrigeminalGanglion2.95
Uterus2.5
UterusCorpus2.65
WholeBlood3.3
Wholebrain2.65
colon3
pineal_day3.76
pineal_night3.66
retina3.625
small_intestine2.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_360_PI417507815
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.56 ± 0.41
Basal Forebrain6.79 ± 0.18
Basal Part of Pons7.04 ± 0.31
Cerebellar Cortex6.81 ± 0.26
Cerebellar Nuclei6.06 ± 0.35
Claustrum7.22 ± 0.47
Epithalamus5.93 ± 0.51
Frontal Lobe6.95 ± 0.54
Globus Pallidus5.45 ± 0.79
Hypothalamus6.44 ± 0.58
Insula7.1 ± 0.41
Limbic Lobe7.54 ± 0.5
Mesencephalon6.76 ± 0.6
Myelencephalon6.92 ± 0.52
Occipital Lobe7.16 ± 0.52
Parietal Lobe6.98 ± 0.58
Pontine Tegmentum6.79 ± 0.54
Striatum6.58 ± 0.62
Subthalamus6.16 ± 0.29
Temporal Lobe7.17 ± 0.4
Thalamus7.01 ± 0.44
White Matter4.94 ± 0.24
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Cdk5r1CBCerebellum28.78
29.18
Cdk5r1CTXCerebral cortex100
100
Cdk5r1HIPHippocampal region91.26
100
Cdk5r1HPFHippocampal formation89.6
100
Cdk5r1HYHypothalamus10.55
9.13
Cdk5r1LSXLateral septal complex67.32
69.72
Cdk5r1MBMidbrain14.44
13.25
Cdk5r1MYMedulla7.77
8.09
Cdk5r1OLFOlfactory bulb100
100
Cdk5r1PPons10.32
8.26
Cdk5r1PALPallidum24.33
24.55
Cdk5r1RHPRetrohippocampal region82.08
85.07
Cdk5r1sAMYStriatum-like amygdalar nuclei45.52
44.4
Cdk5r1STRStriatum75.39
71.61
Cdk5r1STRdStriatum dorsal region76.85
72.12
Cdk5r1STRvStriatum ventral region95.43
88.18
Cdk5r1THThalamus58.24
74.82
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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