AutismKB 2.0

Annotation Detail for IER3


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:IER3 ( DIF-2,DIF2,GLY96,IEX-1,IEX-1L,IEX1,PRG1 )
Gene Full Name: immediate early response 3
Band: 6p21.33
Quick LinksEntrez ID:8870; OMIM: 602996; Uniprot ID:IEX1_HUMAN; ENSEMBL ID: ENSG00000137331; HGNC ID: 5392
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body18 / 70761254
blastocyst7 / 62319112
fetus13 / 56401223
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult157 / 193912180
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma3 / 17475171
breast (mammary gland) tumor8 / 9417884
cervical tumor5 / 34366145
chondrosarcoma20 / 82823241
colorectal tumor16 / 114246140
esophageal tumor0 / 172900 
gastrointestinal tumor9 / 11936975
germ cell tumor3 / 26384511
glioma0 / 1068830 
head and neck tumor13 / 13630295
kidney tumor4 / 6895958
leukemia1 / 9584210
liver tumor21 / 96359217
lung tumor9 / 10312787
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal170 / 336030750
ovarian tumor7 / 7668291
pancreatic tumor16 / 104616152
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor22 / 124949176
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor12 / 90257132
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites4 / 4001599
bladder3 / 29757100
blood3 / 12347824
bone7 / 7165597
bone marrow1 / 4880120
brain14 / 110098912
cervix8 / 48171166
connective tissue10 / 14925566
ear4 / 16212246
embryonic tissue31 / 215722143
esophagus0 / 202090 
eye8 / 21105437
heart2 / 8962622
intestine36 / 234472153
kidney10 / 21177747
larynx1 / 2414541
liver25 / 207743120
lung35 / 336974103
lymph0 / 442700 
lymph node0 / 916100 
mammary gland11 / 15327171
mouth4 / 6705259
muscle1 / 1077159
nerve1 / 1576863
ovary9 / 10205188
pancreas22 / 214812102
parathyroid0 / 205390 
pharynx9 / 41328217
pituitary gland0 / 165850 
placenta27 / 28082596
prostate6 / 18934531
salivary gland0 / 201550 
skin33 / 210574156
spleen0 / 539520 
stomach11 / 96619113
testis0 / 3304420 
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus20 / 23287885
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201631_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts600.1
Adipocyte3.65
AdrenalCortex498.85
Adrenalgland27.1
Amygdala4.6
Appendix12.65
AtrioventricularNode4
BDCA4+_DentriticCells544.5
Bonemarrow55.75
BronchialEpithelialCells2202.55
CD105+_Endothelial4.5
CD14+_Monocytes331.4
CD19+_BCells(neg._sel.)3.85
CD33+_Myeloid1401.8
CD34+5.9
CD4+_Tcells3.95
CD56+_NKCells6.55
CD71+_EarlyErythroid3.4
CD8+_Tcells3.5
CardiacMyocytes724.05
Caudatenucleus3.35
Cerebellum2.9
CerebellumPeduncles4.75
CiliaryGanglion83.8
CingulateCortex4.15
Colorectaladenocarcinoma2370.4
DorsalRootGanglion3.55
FetalThyroid7.65
Fetalbrain5.95
Fetalliver3
Fetallung218.15
GlobusPallidus2.8
Heart93.2
Hypothalamus12.9
Kidney45.45
Leukemia_chronicMyelogenousK-56260.2
Leukemia_promyelocytic-HL-603.2
Leukemialymphoblastic(MOLT-4)3.9
Liver4.8
Lung252.65
Lymphnode68.75
Lymphoma_burkitts(Daudi)4.55
Lymphoma_burkitts(Raji)4.8
MedullaOblongata3.35
OccipitalLobe4.15
OlfactoryBulb62.25
Ovary3.35
Pancreas166.4
PancreaticIslet1912.4
ParietalLobe3.6
Pituitary5.95
Placenta79.2
Pons11.1
PrefrontalCortex4.85
Prostate111.1
Salivarygland12.05
SkeletalMuscle6.2
Skin5.35
SmoothMuscle1543.95
Spinalcord42.5
SubthalamicNucleus4.5
SuperiorCervicalGanglion11
TemporalLobe3.4
Testis3.25
TestisGermCell4.95
TestisIntersitial3.1
TestisLeydigCell3.7
TestisSeminiferousTubule3.3
Thalamus4.65
Thymus19.75
Thyroid35.3
Tongue225.6
Tonsil30.35
Trachea118.4
TrigeminalGanglion16.2
Uterus120.1
UterusCorpus396.65
WholeBlood154.8
Wholebrain3.65
colon290.4
pineal_day10.68
pineal_night48.34
retina84.925
small_intestine19
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16264_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.24 ± 0.85
Basal Forebrain1.82 ± 0.6
Basal Part of Pons1.85 ± 0.71
Cerebellar Cortex1.69 ± 0.69
Cerebellar Nuclei1.89 ± 0.66
Claustrum2.46 ± 0.76
Epithalamus1.76 ± 0.68
Frontal Lobe1.91 ± 0.85
Globus Pallidus2.13 ± 0.66
Hypothalamus1.75 ± 0.88
Insula1.91 ± 0.61
Limbic Lobe1.99 ± 0.64
Mesencephalon2.13 ± 0.79
Myelencephalon2.04 ± 0.69
Occipital Lobe1.88 ± 0.77
Parietal Lobe2.04 ± 0.7
Pontine Tegmentum1.82 ± 0.74
Striatum2.28 ± 0.65
Subthalamus1.62 ± 0.65
Temporal Lobe1.89 ± 0.76
Thalamus2.16 ± 0.81
White Matter2.06 ± 0.67
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ier3CBCerebellum16.08
27
Ier3CTXCerebral cortex13.36
6.7
Ier3HIPHippocampal region1.97
1.82
Ier3HPFHippocampal formation2.15
1.72
Ier3HYHypothalamus1.86
0.92
Ier3LSXLateral septal complex1.06
0.8
Ier3MBMidbrain3.67
3.21
Ier3MYMedulla8.69
8.52
Ier3OLFOlfactory bulb5.83
3.45
Ier3PPons5.95
5.76
Ier3PALPallidum1.82
1.36
Ier3RHPRetrohippocampal region2.31
1.5
Ier3sAMYStriatum-like amygdalar nuclei4.74
2.37
Ier3STRStriatum4.24
2.6
Ier3STRdStriatum dorsal region4.92
3.14
Ier3STRvStriatum ventral region2.7
1.45
Ier3THThalamus10.13
6.67
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved