AutismKB 2.0

Annotation Detail for SPHK1


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Basic Information Top
Gene Symbol:SPHK1 ( SPHK )
Gene Full Name: sphingosine kinase 1
Band: 17q25.2
Quick LinksEntrez ID:8877; OMIM: 603730; Uniprot ID:SPHK1_HUMAN; ENSEMBL ID: ENSG00000176170; HGNC ID: 11240
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst0 / 623190 
fetus9 / 56401215
neonate2 / 3109764
infant0 / 236200 
juvenile1 / 5555617
adult54 / 193912127
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor1 / 3436629
chondrosarcoma1 / 8282312
colorectal tumor2 / 11424617
esophageal tumor4 / 17290231
gastrointestinal tumor4 / 11936933
germ cell tumor2 / 2638457
glioma1 / 1068839
head and neck tumor10 / 13630273
kidney tumor3 / 6895943
leukemia1 / 9584210
liver tumor3 / 9635931
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia6 / 9725061
normal81 / 336030724
ovarian tumor2 / 7668226
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor22 / 124949176
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder1 / 2975733
blood6 / 12347848
bone5 / 7165569
bone marrow1 / 4880120
brain19 / 110098917
cervix7 / 48171145
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus4 / 20209197
eye7 / 21105433
heart1 / 8962611
intestine4 / 23447217
kidney4 / 21177718
larynx2 / 2414582
liver3 / 20774314
lung14 / 33697441
lymph0 / 442700 
lymph node0 / 916100 
mammary gland10 / 15327165
mouth2 / 6705229
muscle0 / 1077150 
nerve0 / 157680 
ovary2 / 10205119
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta3 / 28082510
prostate4 / 18934521
salivary gland2 / 2015599
skin31 / 210574147
spleen2 / 5395237
stomach1 / 9661910
testis1 / 3304423
thymus6 / 8113173
thyroid7 / 47473147
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord2 / 13680146
uterus5 / 23287821
vascular8 / 51780154
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219257_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.1
Adipocyte6.45
AdrenalCortex5.75
Adrenalgland4.5
Amygdala5.45
Appendix5.4
AtrioventricularNode4.35
BDCA4+_DentriticCells7.4
Bonemarrow5.3
BronchialEpithelialCells43.45
CD105+_Endothelial6.3
CD14+_Monocytes5.8
CD19+_BCells(neg._sel.)5.55
CD33+_Myeloid6.5
CD34+6.35
CD4+_Tcells5.5
CD56+_NKCells5.95
CD71+_EarlyErythroid7.35
CD8+_Tcells4.85
CardiacMyocytes6.75
Caudatenucleus4.8
Cerebellum4.35
CerebellumPeduncles6.05
CiliaryGanglion5
CingulateCortex5.5
Colorectaladenocarcinoma5.4
DorsalRootGanglion4.3
FetalThyroid5.2
Fetalbrain5.45
Fetalliver4.65
Fetallung4.7
GlobusPallidus4.05
Heart6.75
Hypothalamus5.7
Kidney4.35
Leukemia_chronicMyelogenousK-5625
Leukemia_promyelocytic-HL-604.75
Leukemialymphoblastic(MOLT-4)4.35
Liver7
Lung6
Lymphnode4.7
Lymphoma_burkitts(Daudi)6.85
Lymphoma_burkitts(Raji)7.5
MedullaOblongata4.9
OccipitalLobe4.85
OlfactoryBulb4.25
Ovary3.55
Pancreas4.3
PancreaticIslet6.1
ParietalLobe5.75
Pituitary6.3
Placenta5.6
Pons5.15
PrefrontalCortex6.15
Prostate6.15
Salivarygland4.3
SkeletalMuscle6.7
Skin4.45
SmoothMuscle66.45
Spinalcord6.2
SubthalamicNucleus4.85
SuperiorCervicalGanglion6.15
TemporalLobe4.9
Testis4.65
TestisGermCell4.35
TestisIntersitial4.5
TestisLeydigCell5.35
TestisSeminiferousTubule4.65
Thalamus5.45
Thymus4.3
Thyroid6.55
Tongue6.3
Tonsil5.25
Trachea4.55
TrigeminalGanglion5.5
Uterus4.8
UterusCorpus4.85
WholeBlood5.6
Wholebrain4.6
colon5.15
pineal_day6.54
pineal_night6.4
retina6.725
small_intestine4.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14492_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.04 ± 1.07
Basal Forebrain2.64 ± 0.3
Basal Part of Pons2.46 ± 0.47
Cerebellar Cortex2.72 ± 0.72
Cerebellar Nuclei2.9 ± 0.76
Claustrum3.21 ± 0.76
Epithalamus2.33 ± 1.09
Frontal Lobe2.62 ± 0.73
Globus Pallidus2.83 ± 0.65
Hypothalamus2.74 ± 0.6
Insula2.3 ± 0.59
Limbic Lobe2.76 ± 0.7
Mesencephalon2.8 ± 0.72
Myelencephalon2.73 ± 0.7
Occipital Lobe2.85 ± 0.72
Parietal Lobe2.65 ± 0.79
Pontine Tegmentum2.62 ± 0.83
Striatum2.58 ± 0.7
Subthalamus2.78 ± 0.75
Temporal Lobe2.67 ± 0.83
Thalamus2.56 ± 0.68
White Matter3.2 ± 0.41
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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