AutismKB 2.0

Annotation Detail for ZNF259


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Basic Information Top
Gene Symbol:ZNF259 ( MGC110983,ZPR1 )
Gene Full Name: zinc finger protein 259
Band: 11q23.3
Quick LinksEntrez ID:8882; OMIM: 603901; Uniprot ID:ZPR1_HUMAN; ENSEMBL ID: ENSG00000109917; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst0 / 623190 
fetus13 / 56401223
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult100 / 193912151
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor15 / 94178159
cervical tumor1 / 3436629
chondrosarcoma4 / 8282348
colorectal tumor13 / 114246113
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor11 / 26384541
glioma6 / 10688356
head and neck tumor14 / 136302102
kidney tumor11 / 68959159
leukemia3 / 9584231
liver tumor13 / 96359134
lung tumor14 / 103127135
lymphoma5 / 7175569
non-neoplasia1 / 9725010
normal99 / 336030729
ovarian tumor8 / 76682104
pancreatic tumor12 / 104616114
primitive neuroectodermal tumor of the CNS11 / 12568087
prostate cancer6 / 10268058
retinoblastoma4 / 4635686
skin tumor14 / 124949112
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites2 / 4001549
bladder3 / 29757100
blood5 / 12347840
bone6 / 7165583
bone marrow1 / 4880120
brain26 / 110098923
cervix2 / 4817141
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue6 / 21572227
esophagus0 / 202090 
eye21 / 21105499
heart0 / 896260 
intestine15 / 23447263
kidney19 / 21177789
larynx0 / 241450 
liver14 / 20774367
lung25 / 33697474
lymph0 / 442700 
lymph node3 / 9161032
mammary gland15 / 15327197
mouth3 / 6705244
muscle0 / 1077150 
nerve1 / 1576863
ovary9 / 10205188
pancreas12 / 21481255
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta12 / 28082542
prostate13 / 18934568
salivary gland8 / 20155396
skin14 / 21057466
spleen1 / 5395218
stomach1 / 9661910
testis12 / 33044236
thymus0 / 811310 
thyroid3 / 4747363
tonsil3 / 16999176
trachea0 / 524130 
umbilical cord0 / 136800 
uterus18 / 23287877
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 200054_at
Cell line Expression level Expression bar
721_B_lymphoblasts22.55
Adipocyte8.2
AdrenalCortex8.45
Adrenalgland7.6
Amygdala7.95
Appendix8.9
AtrioventricularNode7.3
BDCA4+_DentriticCells12.8
Bonemarrow8.2
BronchialEpithelialCells12
CD105+_Endothelial14.65
CD14+_Monocytes11.35
CD19+_BCells(neg._sel.)8.8
CD33+_Myeloid16.75
CD34+17.8
CD4+_Tcells9.1
CD56+_NKCells13.1
CD71+_EarlyErythroid8.25
CD8+_Tcells8.15
CardiacMyocytes7.95
Caudatenucleus7.85
Cerebellum7.15
CerebellumPeduncles8.75
CiliaryGanglion6.85
CingulateCortex8.3
Colorectaladenocarcinoma9.25
DorsalRootGanglion7.2
FetalThyroid8
Fetalbrain8.15
Fetalliver7.8
Fetallung7.25
GlobusPallidus7
Heart8.75
Hypothalamus8.3
Kidney7.4
Leukemia_chronicMyelogenousK-56212.25
Leukemia_promyelocytic-HL-608.6
Leukemialymphoblastic(MOLT-4)7.3
Liver9.4
Lung8.8
Lymphnode7.5
Lymphoma_burkitts(Daudi)11.95
Lymphoma_burkitts(Raji)9.15
MedullaOblongata7.7
OccipitalLobe7.65
OlfactoryBulb7.2
Ovary6.55
Pancreas7.35
PancreaticIslet8.55
ParietalLobe7.95
Pituitary8.65
Placenta8.25
Pons8
PrefrontalCortex8.55
Prostate8.75
Salivarygland7.3
SkeletalMuscle8.9
Skin7.2
SmoothMuscle8.75
Spinalcord8.4
SubthalamicNucleus7.8
SuperiorCervicalGanglion8.85
TemporalLobe7.8
Testis17.1
TestisGermCell10.35
TestisIntersitial9
TestisLeydigCell8.15
TestisSeminiferousTubule7.45
Thalamus8.35
Thymus7.35
Thyroid8.85
Tongue8.2
Tonsil7.8
Trachea7.75
TrigeminalGanglion8.25
Uterus7
UterusCorpus7.7
WholeBlood8.5
Wholebrain7.5
colon8.1
pineal_day8.7
pineal_night8.8
retina8.775
small_intestine8.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_3106_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.31 ± 0.35
Basal Forebrain6.1 ± 0.15
Basal Part of Pons5.96 ± 0.2
Cerebellar Cortex5.82 ± 0.26
Cerebellar Nuclei6.31 ± 0.39
Claustrum6.47 ± 0.48
Epithalamus5.65 ± 0.27
Frontal Lobe6.1 ± 0.34
Globus Pallidus6.05 ± 0.16
Hypothalamus6.15 ± 0.37
Insula5.89 ± 0.21
Limbic Lobe6.24 ± 0.35
Mesencephalon6.15 ± 0.36
Myelencephalon6.1 ± 0.32
Occipital Lobe6.08 ± 0.38
Parietal Lobe6.09 ± 0.3
Pontine Tegmentum6.04 ± 0.36
Striatum6.16 ± 0.36
Subthalamus6 ± 0.25
Temporal Lobe6.06 ± 0.32
Thalamus5.97 ± 0.32
White Matter5.98 ± 0.43
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Zfp259CBCerebellum0.68
1.11
Zfp259CTXCerebral cortex0.85
1.09
Zfp259HIPHippocampal region6.5
7.25
Zfp259HPFHippocampal formation4.64
4.96
Zfp259HYHypothalamus0.7
0.88
Zfp259LSXLateral septal complex0.42
1.35
Zfp259MBMidbrain0.44
1.33
Zfp259MYMedulla0.51
1.06
Zfp259OLFOlfactory bulb3.35
3.92
Zfp259PPons0.82
1.93
Zfp259PALPallidum0.33
0.61
Zfp259RHPRetrohippocampal region0.37
0.67
Zfp259sAMYStriatum-like amygdalar nuclei0.63
0.62
Zfp259STRStriatum1.23
0.56
Zfp259STRdStriatum dorsal region1.26
0.14
Zfp259STRvStriatum ventral region2.18
1.88
Zfp259THThalamus0.67
0.98
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00075615 16 368 383 NPFTLGDSSNPGQTER Peptide Atlas
ZPR1_HUMAN_227 23 227 249 QQEEMLGLQEEAPAEKPEEEDLR PRIDE
ZPR1_HUMAN_295 16 295 310 TNEVKSGGAVEPLGTR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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