AutismKB 2.0

Annotation Detail for CPNE3


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Basic Information Top
Gene Symbol:CPNE3 ( CPN3,KIAA0636,PRO1071 )
Gene Full Name: copine III
Band: 8q21.3
Quick LinksEntrez ID:8895; OMIM: 604207; Uniprot ID:CPNE3_HUMAN; ENSEMBL ID: ENSG00000085719; HGNC ID: 2316
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst3 / 6231948
fetus35 / 56401262
neonate0 / 310970 
infant1 / 2362042
juvenile1 / 5555617
adult129 / 193912166
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma3 / 17475171
breast (mammary gland) tumor8 / 9417884
cervical tumor1 / 3436629
chondrosarcoma10 / 82823120
colorectal tumor4 / 11424635
esophageal tumor2 / 17290115
gastrointestinal tumor4 / 11936933
germ cell tumor5 / 26384518
glioma14 / 106883130
head and neck tumor37 / 136302271
kidney tumor0 / 689590 
leukemia5 / 9584252
liver tumor4 / 9635941
lung tumor4 / 10312738
lymphoma1 / 7175513
non-neoplasia2 / 9725020
normal245 / 336030772
ovarian tumor0 / 766820 
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer14 / 102680136
retinoblastoma0 / 463560 
skin tumor4 / 12494932
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue4 / 13106305
adrenal gland0 / 331970 
ascites1 / 4001524
bladder4 / 29757134
blood3 / 12347824
bone8 / 71655111
bone marrow7 / 48801143
brain64 / 110098958
cervix6 / 48171124
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue13 / 21572260
esophagus2 / 2020998
eye5 / 21105423
heart6 / 8962666
intestine10 / 23447242
kidney23 / 211777108
larynx1 / 2414541
liver14 / 20774367
lung24 / 33697471
lymph0 / 442700 
lymph node34 / 91610371
mammary gland17 / 153271110
mouth34 / 67052507
muscle12 / 107715111
nerve0 / 157680 
ovary1 / 1020519
pancreas13 / 21481260
parathyroid6 / 20539292
pharynx2 / 4132848
pituitary gland1 / 1658560
placenta18 / 28082564
prostate25 / 189345132
salivary gland1 / 2015549
skin13 / 21057461
spleen1 / 5395218
stomach1 / 9661910
testis4 / 33044212
thymus4 / 8113149
thyroid5 / 47473105
tonsil2 / 16999117
trachea19 / 52413362
umbilical cord0 / 136800 
uterus13 / 23287855
vascular8 / 51780154
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202118_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts17.2
Adipocyte5.7
AdrenalCortex7.05
Adrenalgland5
Amygdala5.75
Appendix6.85
AtrioventricularNode4.7
BDCA4+_DentriticCells175.45
Bonemarrow22.9
BronchialEpithelialCells71.7
CD105+_Endothelial11.6
CD14+_Monocytes15
CD19+_BCells(neg._sel.)16.55
CD33+_Myeloid58.65
CD34+18.4
CD4+_Tcells19.5
CD56+_NKCells54.95
CD71+_EarlyErythroid5.2
CD8+_Tcells18.8
CardiacMyocytes7.8
Caudatenucleus5
Cerebellum4.5
CerebellumPeduncles6.4
CiliaryGanglion5.2
CingulateCortex5.65
Colorectaladenocarcinoma4.95
DorsalRootGanglion4.8
FetalThyroid7.3
Fetalbrain5.45
Fetalliver5.15
Fetallung4.75
GlobusPallidus4.2
Heart7.5
Hypothalamus6
Kidney17.5
Leukemia_chronicMyelogenousK-5625
Leukemia_promyelocytic-HL-604.7
Leukemialymphoblastic(MOLT-4)4.55
Liver7.25
Lung7.6
Lymphnode4.75
Lymphoma_burkitts(Daudi)6.9
Lymphoma_burkitts(Raji)8.05
MedullaOblongata5.15
OccipitalLobe4.7
OlfactoryBulb5.2
Ovary4.15
Pancreas4.7
PancreaticIslet25.95
ParietalLobe6
Pituitary9.45
Placenta5.8
Pons5.25
PrefrontalCortex6.95
Prostate29.3
Salivarygland5.1
SkeletalMuscle7.4
Skin4.65
SmoothMuscle7.95
Spinalcord5.9
SubthalamicNucleus5.05
SuperiorCervicalGanglion14.8
TemporalLobe5.05
Testis4.5
TestisGermCell4.6
TestisIntersitial4.6
TestisLeydigCell5.6
TestisSeminiferousTubule4.8
Thalamus5.65
Thymus27.7
Thyroid12.9
Tongue10.75
Tonsil9.05
Trachea5.35
TrigeminalGanglion6.4
Uterus20
UterusCorpus5.4
WholeBlood8.8
Wholebrain4.55
colon75.9
pineal_day14.46
pineal_night18.18
retina8.4
small_intestine185.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P94370
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8 ± 0.39
Basal Forebrain7.89 ± 0.16
Basal Part of Pons7.16 ± 0.27
Cerebellar Cortex7.47 ± 0.26
Cerebellar Nuclei7.72 ± 0.45
Claustrum7.94 ± 0.57
Epithalamus8.18 ± 0.38
Frontal Lobe7.5 ± 0.38
Globus Pallidus8.57 ± 0.25
Hypothalamus8.04 ± 0.42
Insula7.61 ± 0.37
Limbic Lobe7.74 ± 0.47
Mesencephalon7.87 ± 0.35
Myelencephalon7.72 ± 0.46
Occipital Lobe7.89 ± 0.42
Parietal Lobe7.51 ± 0.39
Pontine Tegmentum7.73 ± 0.25
Striatum7.96 ± 0.4
Subthalamus7.34 ± 0.23
Temporal Lobe7.64 ± 0.37
Thalamus7.62 ± 0.31
White Matter8.52 ± 0.28
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Cpne3CBCerebellum2.84
4.35
Cpne3CTXCerebral cortex0.95
0.64
Cpne3HIPHippocampal region0.38
0.37
Cpne3HPFHippocampal formation0.67
0.49
Cpne3HYHypothalamus0.37
0.33
Cpne3LSXLateral septal complex0.26
1.11
Cpne3MBMidbrain0.85
0.82
Cpne3MYMedulla3.46
2.87
Cpne3OLFOlfactory bulb3.69
2.64
Cpne3PPons2.52
2.23
Cpne3PALPallidum1.19
0.77
Cpne3RHPRetrohippocampal region1.04
0.62
Cpne3sAMYStriatum-like amygdalar nuclei0.27
0.13
Cpne3STRStriatum0.47
0.53
Cpne3STRdStriatum dorsal region0.39
0.4
Cpne3STRvStriatum ventral region0.9
0.99
Cpne3THThalamus0.54
0.84
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
CPNE3_HUMAN_110 9 110 118 KLTRPLVMK PRIDE
CPNE3_HUMAN_125 14 125 138 GSITISAEEIKDNR PRIDE
CPNE3_HUMAN_139 9 139 147 VVLFEMEAR PRIDE
CPNE3_HUMAN_140 9 140 148 VVLFEMEAR PRIDE
CPNE3_HUMAN_168 12 168 179 QTSDGNWLMVHR PRIDE
CPNE3_HUMAN_390 16 390 405 LYGPTNFSPIINHVAR PRIDE
CPNE3_HUMAN_439 8 439 446 QAIVNASR PRIDE
CPNE3_HUMAN_484 9 484 492 DIVQFVPFR PRIDE
CPNE3_HUMAN_500 23 500 522 EALAQCVLAEIPQQVVGYFNTYK PRIDE
CPNE3_HUMAN_8 18 8 25 VALNVSCANLLDKDIGSK PRIDE
PAp00001907 23 501 523 EALAQCVLAEIPQQVVGYFNTYK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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