AutismKB 2.0

Annotation Detail for PRPF4B


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Basic Information Top
Gene Symbol:PRPF4B ( KIAA0536,PR4H,PRP4,PRP4H,PRP4K,dJ1013A10.1 )
Gene Full Name: PRP4 pre-mRNA processing factor 4 homolog B (yeast)
Band: 6p25.2
Quick LinksEntrez ID:8899; OMIM: 602338; Uniprot ID:PRP4B_HUMAN; ENSEMBL ID: ENSG00000112739; HGNC ID: 17346
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst6 / 6231996
fetus50 / 56401288
neonate1 / 3109732
infant1 / 2362042
juvenile2 / 5555635
adult163 / 193912184
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma2 / 17475114
breast (mammary gland) tumor4 / 9417842
cervical tumor1 / 3436629
chondrosarcoma9 / 82823108
colorectal tumor8 / 11424670
esophageal tumor2 / 17290115
gastrointestinal tumor11 / 11936992
germ cell tumor27 / 263845102
glioma2 / 10688318
head and neck tumor14 / 136302102
kidney tumor6 / 6895987
leukemia11 / 95842114
liver tumor7 / 9635972
lung tumor4 / 10312738
lymphoma9 / 71755125
non-neoplasia7 / 9725071
normal258 / 336030776
ovarian tumor1 / 7668213
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer7 / 10268068
retinoblastoma3 / 4635664
skin tumor2 / 12494916
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites0 / 400150 
bladder4 / 29757134
blood7 / 12347856
bone7 / 7165597
bone marrow9 / 48801184
brain64 / 110098958
cervix1 / 4817120
connective tissue9 / 14925560
ear2 / 16212123
embryonic tissue17 / 21572278
esophagus2 / 2020998
eye14 / 21105466
heart4 / 8962644
intestine16 / 23447268
kidney19 / 21177789
larynx0 / 241450 
liver24 / 207743115
lung26 / 33697477
lymph6 / 44270135
lymph node13 / 91610141
mammary gland11 / 15327171
mouth7 / 67052104
muscle9 / 10771583
nerve1 / 1576863
ovary1 / 1020519
pancreas8 / 21481237
parathyroid2 / 2053997
pharynx5 / 41328120
pituitary gland0 / 165850 
placenta25 / 28082589
prostate15 / 18934579
salivary gland0 / 201550 
skin3 / 21057414
spleen4 / 5395274
stomach11 / 96619113
testis36 / 330442108
thymus15 / 81131184
thyroid7 / 47473147
tonsil0 / 169990 
trachea13 / 52413248
umbilical cord0 / 136800 
uterus21 / 23287890
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211090_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts28.9
Adipocyte6.8
AdrenalCortex5.65
Adrenalgland4.3
Amygdala5
Appendix5.15
AtrioventricularNode4.1
BDCA4+_DentriticCells86.75
Bonemarrow4.95
BronchialEpithelialCells4.95
CD105+_Endothelial26.25
CD14+_Monocytes10.4
CD19+_BCells(neg._sel.)21.9
CD33+_Myeloid64.25
CD34+89.05
CD4+_Tcells87.7
CD56+_NKCells71.55
CD71+_EarlyErythroid6.25
CD8+_Tcells67.45
CardiacMyocytes9.8
Caudatenucleus4.4
Cerebellum3.95
CerebellumPeduncles5.75
CiliaryGanglion3.7
CingulateCortex5.15
Colorectaladenocarcinoma4.95
DorsalRootGanglion3.95
FetalThyroid4.85
Fetalbrain5.05
Fetalliver8.6
Fetallung4.6
GlobusPallidus3.8
Heart6.75
Hypothalamus5.3
Kidney4.1
Leukemia_chronicMyelogenousK-5624.95
Leukemia_promyelocytic-HL-604.35
Leukemialymphoblastic(MOLT-4)7.65
Liver6.8
Lung5.2
Lymphnode9
Lymphoma_burkitts(Daudi)6.5
Lymphoma_burkitts(Raji)7.05
MedullaOblongata4.3
OccipitalLobe4.4
OlfactoryBulb3.9
Ovary3.8
Pancreas4
PancreaticIslet5.4
ParietalLobe5.75
Pituitary5.95
Placenta4.8
Pons4.75
PrefrontalCortex6.05
Prostate5.45
Salivarygland4.05
SkeletalMuscle6.05
Skin4.25
SmoothMuscle5.55
Spinalcord5.1
SubthalamicNucleus4.65
SuperiorCervicalGanglion5.95
TemporalLobe4.55
Testis4.1
TestisGermCell4.9
TestisIntersitial6.35
TestisLeydigCell4.95
TestisSeminiferousTubule4.15
Thalamus5
Thymus3.8
Thyroid6.1
Tongue5
Tonsil7.6
Trachea4.3
TrigeminalGanglion5.15
Uterus8.75
UterusCorpus4.6
WholeBlood9.2
Wholebrain3.95
colon5.1
pineal_day11.68
pineal_night10.24
retina5.825
small_intestine4.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P403168
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.44 ± 0.37
Basal Forebrain6.48 ± 0.27
Basal Part of Pons6.48 ± 0.21
Cerebellar Cortex6.69 ± 0.36
Cerebellar Nuclei6.54 ± 0.33
Claustrum6.55 ± 0.53
Epithalamus7.07 ± 0.32
Frontal Lobe6.47 ± 0.4
Globus Pallidus6.49 ± 0.28
Hypothalamus6.74 ± 0.35
Insula6.56 ± 0.37
Limbic Lobe6.5 ± 0.38
Mesencephalon6.56 ± 0.36
Myelencephalon6.47 ± 0.42
Occipital Lobe6.66 ± 0.31
Parietal Lobe6.53 ± 0.38
Pontine Tegmentum6.6 ± 0.36
Striatum6.56 ± 0.44
Subthalamus6.63 ± 0.37
Temporal Lobe6.44 ± 0.33
Thalamus6.46 ± 0.4
White Matter6.9 ± 0.16
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Prpf4bCBCerebellum6
5.48
Prpf4bCTXCerebral cortex10.71
6.51
Prpf4bHIPHippocampal region13.86
13.16
Prpf4bHPFHippocampal formation11.74
9.93
Prpf4bHYHypothalamus3.41
2.34
Prpf4bLSXLateral septal complex3.6
2.17
Prpf4bMBMidbrain6.08
4.52
Prpf4bMYMedulla7.29
6.33
Prpf4bOLFOlfactory bulb18.34
14.45
Prpf4bPPons6.01
4.87
Prpf4bPALPallidum5.92
4.13
Prpf4bRHPRetrohippocampal region8.66
6
Prpf4bsAMYStriatum-like amygdalar nuclei1.2
0.71
Prpf4bSTRStriatum4.7
3.33
Prpf4bSTRdStriatum dorsal region4.54
3.64
Prpf4bSTRvStriatum ventral region7.17
4.05
Prpf4bTHThalamus6.43
4.62
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00009599 19 809 827 CNILHADIKPDNILVNESK Peptide Atlas
PRP4B_HUMAN_196 19 196 214 SDKKKSKGGIEIVKEKTTR PRIDE
PRP4B_HUMAN_2 9 2 10 AAAETQSLR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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