AutismKB 2.0

Annotation Detail for CCNB1


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Basic Information Top
Gene Symbol:CCNB1 ( CCNB )
Gene Full Name: cyclin B1
Band: 5q13.2
Quick LinksEntrez ID:891; OMIM: 123836; Uniprot ID:CCNB1_HUMAN; ENSEMBL ID: ENSG00000134057; HGNC ID: 1579
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body14 / 70761197
blastocyst22 / 62319353
fetus28 / 56401249
neonate2 / 3109764
infant12 / 23620508
juvenile13 / 55556233
adult185 / 193912195
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma3 / 17475171
breast (mammary gland) tumor24 / 94178254
cervical tumor14 / 34366407
chondrosarcoma14 / 82823169
colorectal tumor29 / 114246253
esophageal tumor6 / 17290347
gastrointestinal tumor25 / 119369209
germ cell tumor68 / 263845257
glioma13 / 106883121
head and neck tumor7 / 13630251
kidney tumor19 / 68959275
leukemia5 / 9584252
liver tumor30 / 96359311
lung tumor24 / 103127232
lymphoma36 / 71755501
non-neoplasia0 / 972500 
normal237 / 336030770
ovarian tumor22 / 76682286
pancreatic tumor23 / 104616219
primitive neuroectodermal tumor of the CNS91 / 125680724
prostate cancer35 / 102680340
retinoblastoma12 / 46356258
skin tumor62 / 124949496
soft tissue/muscle tissue tumor59 / 125191471
uterine tumor9 / 9025799
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland3 / 3319790
ascites11 / 40015274
bladder5 / 29757168
blood14 / 123478113
bone16 / 71655223
bone marrow3 / 4880161
brain95 / 110098986
cervix14 / 48171290
connective tissue6 / 14925540
ear2 / 16212123
embryonic tissue57 / 215722264
esophagus6 / 20209296
eye25 / 211054118
heart2 / 8962622
intestine38 / 234472162
kidney19 / 21177789
larynx1 / 2414541
liver42 / 207743202
lung42 / 336974124
lymph27 / 44270609
lymph node10 / 91610109
mammary gland26 / 153271169
mouth3 / 6705244
muscle31 / 107715287
nerve0 / 157680 
ovary29 / 102051284
pancreas23 / 214812107
parathyroid0 / 205390 
pharynx6 / 41328145
pituitary gland1 / 1658560
placenta75 / 280825267
prostate35 / 189345184
salivary gland5 / 20155248
skin63 / 210574299
spleen3 / 5395255
stomach12 / 96619124
testis21 / 33044263
thymus7 / 8113186
thyroid2 / 4747342
tonsil4 / 16999235
trachea1 / 5241319
umbilical cord2 / 13680146
uterus37 / 232878158
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 214710_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts376.5
Adipocyte4.45
AdrenalCortex4.85
Adrenalgland3.75
Amygdala4.45
Appendix4.85
AtrioventricularNode3.8
BDCA4+_DentriticCells5.05
Bonemarrow19.3
BronchialEpithelialCells95.35
CD105+_Endothelial218.05
CD14+_Monocytes4.6
CD19+_BCells(neg._sel.)4.35
CD33+_Myeloid7
CD34+76.05
CD4+_Tcells4.15
CD56+_NKCells5.55
CD71+_EarlyErythroid331.75
CD8+_Tcells3.8
CardiacMyocytes152.4
Caudatenucleus3.95
Cerebellum3.5
CerebellumPeduncles5.1
CiliaryGanglion3.2
CingulateCortex4.35
Colorectaladenocarcinoma70.5
DorsalRootGanglion4.4
FetalThyroid4.35
Fetalbrain4.45
Fetalliver44.05
Fetallung3.8
GlobusPallidus3.35
Heart5.85
Hypothalamus4.85
Kidney3.65
Leukemia_chronicMyelogenousK-56264.1
Leukemia_promyelocytic-HL-60107.4
Leukemialymphoblastic(MOLT-4)79.2
Liver6.5
Lung4.7
Lymphnode3.65
Lymphoma_burkitts(Daudi)145.55
Lymphoma_burkitts(Raji)6.25
MedullaOblongata4.1
OccipitalLobe3.85
OlfactoryBulb3.35
Ovary3.15
Pancreas3.6
PancreaticIslet4.8
ParietalLobe4.6
Pituitary4.9
Placenta5.1
Pons4.25
PrefrontalCortex5.25
Prostate5.3
Salivarygland3.6
SkeletalMuscle5.45
Skin3.6
SmoothMuscle15.6
Spinalcord4.6
SubthalamicNucleus4
SuperiorCervicalGanglion5.05
TemporalLobe4.1
Testis20.7
TestisGermCell7.6
TestisIntersitial12.9
TestisLeydigCell4.7
TestisSeminiferousTubule6.5
Thalamus4.55
Thymus60.1
Thyroid5.7
Tongue4.45
Tonsil13.15
Trachea3.8
TrigeminalGanglion4.9
Uterus3.3
UterusCorpus4
WholeBlood4.65
Wholebrain3.9
colon5.65
pineal_day5.18
pineal_night5.08
retina5
small_intestine43.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16017_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.76 ± 0.48
Basal Forebrain6.81 ± 0.26
Basal Part of Pons7.23 ± 0.17
Cerebellar Cortex6.99 ± 0.27
Cerebellar Nuclei6.96 ± 0.28
Claustrum6.2 ± 0.74
Epithalamus6.4 ± 0.33
Frontal Lobe6.77 ± 0.38
Globus Pallidus6.44 ± 0.38
Hypothalamus6.76 ± 0.38
Insula6.69 ± 0.27
Limbic Lobe6.61 ± 0.37
Mesencephalon6.56 ± 0.41
Myelencephalon6.66 ± 0.45
Occipital Lobe6.41 ± 0.38
Parietal Lobe6.67 ± 0.35
Pontine Tegmentum6.61 ± 0.26
Striatum6.32 ± 0.44
Subthalamus6.71 ± 0.51
Temporal Lobe6.72 ± 0.35
Thalamus6.74 ± 0.41
White Matter5.87 ± 0.05
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ccnb1CBCerebellum0.87
2.41
Ccnb1CTXCerebral cortex0.74
1.15
Ccnb1HIPHippocampal region0.8
1.03
Ccnb1HPFHippocampal formation0.99
1.26
Ccnb1HYHypothalamus11.09
16.25
Ccnb1LSXLateral septal complex0.38
0.39
Ccnb1MBMidbrain1.05
1.48
Ccnb1MYMedulla0.56
1.08
Ccnb1OLFOlfactory bulb3.28
6.23
Ccnb1PPons2.34
4.31
Ccnb1PALPallidum2.22
3.25
Ccnb1RHPRetrohippocampal region1.03
1.19
Ccnb1sAMYStriatum-like amygdalar nuclei5.12
8.26
Ccnb1STRStriatum1.16
1.9
Ccnb1STRdStriatum dorsal region0.28
0.29
Ccnb1STRvStriatum ventral region2.67
4.96
Ccnb1THThalamus0.22
0.23
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
CCNB1_HUMAN_284 8 284 291 QMEMKILR PRIDE
PAp00070277 13 312 324 IGEVDVEQHTLAK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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