AutismKB 2.0

Annotation Detail for TIMELESS


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Basic Information Top
Gene Symbol:TIMELESS ( FLJ12640,FLJ20714,TIM,TIM1,hTIM )
Gene Full Name: timeless homolog (Drosophila)
Band: 12q13.3
Quick LinksEntrez ID:8914; OMIM: 603887; Uniprot ID:TIM_HUMAN; ENSEMBL ID: ENSG00000111602; HGNC ID: 11813
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst11 / 62319176
fetus9 / 56401215
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult94 / 193912148
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor9 / 9417895
cervical tumor2 / 3436658
chondrosarcoma6 / 8282372
colorectal tumor9 / 11424678
esophageal tumor0 / 172900 
gastrointestinal tumor10 / 11936983
germ cell tumor31 / 263845117
glioma9 / 10688384
head and neck tumor14 / 136302102
kidney tumor7 / 68959101
leukemia2 / 9584220
liver tumor0 / 963590 
lung tumor16 / 103127155
lymphoma12 / 71755167
non-neoplasia0 / 972500 
normal77 / 336030722
ovarian tumor5 / 7668265
pancreatic tumor9 / 10461686
primitive neuroectodermal tumor of the CNS11 / 12568087
prostate cancer23 / 102680223
retinoblastoma5 / 46356107
skin tumor20 / 124949160
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites8 / 40015199
bladder2 / 2975767
blood3 / 12347824
bone7 / 7165597
bone marrow1 / 4880120
brain24 / 110098921
cervix4 / 4817183
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue20 / 21572292
esophagus0 / 202090 
eye15 / 21105471
heart0 / 896260 
intestine13 / 23447255
kidney7 / 21177733
larynx1 / 2414541
liver0 / 2077430 
lung22 / 33697465
lymph7 / 44270158
lymph node8 / 9161087
mammary gland9 / 15327158
mouth8 / 67052119
muscle3 / 10771527
nerve0 / 157680 
ovary12 / 102051117
pancreas12 / 21481255
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta13 / 28082546
prostate28 / 189345147
salivary gland2 / 2015599
skin20 / 21057494
spleen1 / 5395218
stomach1 / 9661910
testis9 / 33044227
thymus3 / 8113136
thyroid2 / 4747342
tonsil3 / 16999176
trachea0 / 524130 
umbilical cord0 / 136800 
uterus12 / 23287851
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 215455_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.65
Adipocyte3.7
AdrenalCortex4.05
Adrenalgland3.2
Amygdala3.9
Appendix4.05
AtrioventricularNode2.9
BDCA4+_DentriticCells4.1
Bonemarrow3.75
BronchialEpithelialCells3.65
CD105+_Endothelial3.8
CD14+_Monocytes4
CD19+_BCells(neg._sel.)4
CD33+_Myeloid4.75
CD34+4.75
CD4+_Tcells4.1
CD56+_NKCells4.5
CD71+_EarlyErythroid3.45
CD8+_Tcells3.65
CardiacMyocytes4.85
Caudatenucleus3.35
Cerebellum3
CerebellumPeduncles4.35
CiliaryGanglion2.8
CingulateCortex3.9
Colorectaladenocarcinoma3.7
DorsalRootGanglion2.95
FetalThyroid3.6
Fetalbrain3.75
Fetalliver3.2
Fetallung3.15
GlobusPallidus2.75
Heart4.9
Hypothalamus4.05
Kidney3.05
Leukemia_chronicMyelogenousK-5623.35
Leukemia_promyelocytic-HL-603.3
Leukemialymphoblastic(MOLT-4)3
Liver5
Lung4.1
Lymphnode3.25
Lymphoma_burkitts(Daudi)4.85
Lymphoma_burkitts(Raji)5.3
MedullaOblongata3.45
OccipitalLobe3.35
OlfactoryBulb2.95
Ovary2.5
Pancreas3
PancreaticIslet4.05
ParietalLobe3.95
Pituitary4.4
Placenta3.85
Pons3.85
PrefrontalCortex4.65
Prostate4.4
Salivarygland3
SkeletalMuscle4.5
Skin3.1
SmoothMuscle4.2
Spinalcord4
SubthalamicNucleus3.45
SuperiorCervicalGanglion4.8
TemporalLobe3.45
Testis3.2
TestisGermCell3.15
TestisIntersitial3.15
TestisLeydigCell3.7
TestisSeminiferousTubule3.2
Thalamus3.8
Thymus2.9
Thyroid4.7
Tongue3.8
Tonsil3.7
Trachea3.1
TrigeminalGanglion3.85
Uterus3.05
UterusCorpus3.35
WholeBlood4.1
Wholebrain3.15
colon3.75
pineal_day4.7
pineal_night4.62
retina4.5
small_intestine3.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P231004
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.58 ± 0.95
Basal Forebrain2.16 ± 0.45
Basal Part of Pons1.5 ± 0.42
Cerebellar Cortex2.24 ± 0.71
Cerebellar Nuclei2.67 ± 0.85
Claustrum2.95 ± 0.88
Epithalamus2.01 ± 0.97
Frontal Lobe2.11 ± 0.72
Globus Pallidus3.2 ± 0.74
Hypothalamus2.43 ± 0.4
Insula2.37 ± 0.66
Limbic Lobe2.19 ± 0.8
Mesencephalon2.37 ± 0.71
Myelencephalon2.32 ± 0.76
Occipital Lobe2.3 ± 0.68
Parietal Lobe2.2 ± 0.88
Pontine Tegmentum2.28 ± 0.73
Striatum2.18 ± 0.7
Subthalamus2.42 ± 0.97
Temporal Lobe2.1 ± 0.77
Thalamus2.34 ± 0.65
White Matter3.45 ± 0.82
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
TimelessCBCerebellum43.6
64.22
TimelessCTXCerebral cortex90.25
75.09
TimelessHIPHippocampal region56.61
75.09
TimelessHPFHippocampal formation65.44
71.6
TimelessHYHypothalamus44.67
35.66
TimelessLSXLateral septal complex64.36
49.02
TimelessMBMidbrain69.12
62.13
TimelessMYMedulla68.32
70.96
TimelessOLFOlfactory bulb91.19
87.4
TimelessPPons63.13
60.69
TimelessPALPallidum50.46
45.08
TimelessRHPRetrohippocampal region81.83
67.25
TimelesssAMYStriatum-like amygdalar nuclei35.27
26.07
TimelessSTRStriatum48.05
35.7
TimelessSTRdStriatum dorsal region45.24
34.17
TimelessSTRvStriatum ventral region60.88
42.13
TimelessTHThalamus64.9
58.88
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00040988 18 603 620 IQDCLLAGQAPQALTLLR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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