Annotation Detail for TOP3B
Basic Information Top
| Gene Symbol: | TOP3B ( FLJ39376 ) |
|---|---|
| Gene Full Name: | topoisomerase (DNA) III beta |
| Band: | 22q11.22 |
| Quick Links | Entrez ID:8940; OMIM: 603582; Uniprot ID:TOP3B_HUMAN; ENSEMBL ID: ENSG00000100038; HGNC ID: 11993 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.436401
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 3 / 70761 | 42 |  |
| blastocyst | 6 / 62319 | 96 |  |
| fetus | 26 / 564012 | 46 | |
| neonate | 1 / 31097 | 32 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 2 / 55556 | 35 | |
| adult | 49 / 1939121 | 25 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 1 / 12794 | 78 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 7 / 94178 | 74 | |
| cervical tumor | 1 / 34366 | 29 | |
| chondrosarcoma | 2 / 82823 | 24 | |
| colorectal tumor | 2 / 114246 | 17 | |
| esophageal tumor | 3 / 17290 | 173 | |
| gastrointestinal tumor | 2 / 119369 | 16 | |
| germ cell tumor | 7 / 263845 | 26 | |
| glioma | 4 / 106883 | 37 | |
| head and neck tumor | 9 / 136302 | 66 | |
| kidney tumor | 0 / 68959 | 0 | |
| leukemia | 9 / 95842 | 93 | |
| liver tumor | 6 / 96359 | 62 | |
| lung tumor | 0 / 103127 | 0 | |
| lymphoma | 1 / 71755 | 13 | |
| non-neoplasia | 3 / 97250 | 30 | |
| normal | 127 / 3360307 | 37 | |
| ovarian tumor | 1 / 76682 | 13 | |
| pancreatic tumor | 4 / 104616 | 38 | |
| primitive neuroectodermal tumor of the CNS | 18 / 125680 | 143 | |
| prostate cancer | 4 / 102680 | 38 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 9 / 124949 | 72 | |
| soft tissue/muscle tissue tumor | 3 / 125191 | 23 | |
| uterine tumor | 2 / 90257 | 22 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 1 / 33197 | 30 | |
| ascites | 1 / 40015 | 24 | |
| bladder | 0 / 29757 | 0 | |
| blood | 8 / 123478 | 64 | |
| bone | 0 / 71655 | 0 | |
| bone marrow | 4 / 48801 | 81 | |
| brain | 60 / 1100989 | 54 | |
| cervix | 2 / 48171 | 41 | |
| connective tissue | 3 / 149255 | 20 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 15 / 215722 | 69 | |
| esophagus | 3 / 20209 | 148 | |
| eye | 8 / 211054 | 37 | |
| heart | 2 / 89626 | 22 | |
| intestine | 8 / 234472 | 34 | |
| kidney | 3 / 211777 | 14 | |
| larynx | 0 / 24145 | 0 | |
| liver | 6 / 207743 | 28 | |
| lung | 5 / 336974 | 14 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 5 / 91610 | 54 | |
| mammary gland | 7 / 153271 | 45 | |
| mouth | 9 / 67052 | 134 | |
| muscle | 4 / 107715 | 37 | |
| nerve | 1 / 15768 | 63 | |
| ovary | 1 / 102051 | 9 |  |
| pancreas | 4 / 214812 | 18 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 1 / 41328 | 24 | |
| pituitary gland | 1 / 16585 | 60 | |
| placenta | 2 / 280825 | 7 | |
| prostate | 4 / 189345 | 21 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 12 / 210574 | 56 | |
| spleen | 2 / 53952 | 37 | |
| stomach | 0 / 96619 | 0 | |
| testis | 9 / 330442 | 27 | |
| thymus | 39 / 81131 | 480 |  |
| thyroid | 0 / 47473 | 0 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 4 / 52413 | 76 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 11 / 232878 | 47 | |
| vascular | 3 / 51780 | 57 | |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 215781_s_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 5.2 | |
| Adipocyte | 4 | |
| AdrenalCortex | 4.15 | |
| Adrenalgland | 3.3 | |
| Amygdala | 4.2 | |
| Appendix | 4 | |
| AtrioventricularNode | 3.15 | |
| BDCA4+_DentriticCells | 4.6 | |
| Bonemarrow | 3.9 | |
| BronchialEpithelialCells | 3.95 | |
| CD105+_Endothelial | 4 | |
| CD14+_Monocytes | 4.25 | |
| CD19+_BCells(neg._sel.) | 4.65 | |
| CD33+_Myeloid | 5.25 | |
| CD34+ | 5.2 | |
| CD4+_Tcells | 4.45 | |
| CD56+_NKCells | 4.95 | |
| CD71+_EarlyErythroid | 3.75 | |
| CD8+_Tcells | 4 | |
| CardiacMyocytes | 5.1 | |
| Caudatenucleus | 3.6 | |
| Cerebellum | 3.25 | |
| CerebellumPeduncles | 4.5 | |
| CiliaryGanglion | 2.8 | |
| CingulateCortex | 4 | |
| Colorectaladenocarcinoma | 4 | |
| DorsalRootGanglion | 3 | |
| FetalThyroid | 3.95 | |
| Fetalbrain | 4 | |
| Fetalliver | 3.45 | |
| Fetallung | 3.3 | |
| GlobusPallidus | 2.95 | |
| Heart | 5.55 | |
| Hypothalamus | 4.35 | |
| Kidney | 3.2 | |
| Leukemia_chronicMyelogenousK-562 | 4.6 | |
| Leukemia_promyelocytic-HL-60 | 3.55 | |
| Leukemialymphoblastic(MOLT-4) | 3.25 | |
| Liver | 5.2 | |
| Lung | 4.45 | |
| Lymphnode | 3.5 | |
| Lymphoma_burkitts(Daudi) | 5.1 | |
| Lymphoma_burkitts(Raji) | 5.75 | |
| MedullaOblongata | 3.65 | |
| OccipitalLobe | 3.6 | |
| OlfactoryBulb | 3.2 | |
| Ovary | 2.7 | |
| Pancreas | 3.2 | |
| PancreaticIslet | 4.25 | |
| ParietalLobe | 4.2 | |
| Pituitary | 4.65 | |
| Placenta | 4.05 | |
| Pons | 3.8 | |
| PrefrontalCortex | 4.85 | |
| Prostate | 4.8 | |
| Salivarygland | 3.2 | |
| SkeletalMuscle | 4.6 | |
| Skin | 3 | |
| SmoothMuscle | 4.55 | |
| Spinalcord | 4.3 | |
| SubthalamicNucleus | 3.65 | |
| SuperiorCervicalGanglion | 4.45 | |
| TemporalLobe | 3.65 | |
| Testis | 3.45 | |
| TestisGermCell | 3.25 | |
| TestisIntersitial | 3.35 | |
| TestisLeydigCell | 3.95 | |
| TestisSeminiferousTubule | 3.45 | |
| Thalamus | 4.05 | |
| Thymus | 3.15 | |
| Thyroid | 5.1 | |
| Tongue | 3.9 | |
| Tonsil | 3.9 | |
| Trachea | 3.35 | |
| TrigeminalGanglion | 4 | |
| Uterus | 3.25 | |
| UterusCorpus | 3.55 | |
| WholeBlood | 4.45 | |
| Wholebrain | 3.45 | |
| colon | 4.05 | |
| pineal_day | 4.94 | |
| pineal_night | 4.86 | |
| retina | 4.825 | |
| small_intestine | 3.85 | |
- Probe name: CUST_7777_PI416261804
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 4.1 ± 0.64 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 3.63 ± 0.75 | |
| Basal Part of Pons | 3.77 ± 0.73 | |
| Cerebellar Cortex | 3.91 ± 0.56 | |
| Cerebellar Nuclei | 4.42 ± 0.34 | |
| Claustrum | 4.49 ± 0.97 | |
| Epithalamus | 3.45 ± 0.6 | |
| Frontal Lobe | 3.71 ± 0.72 | |
| Globus Pallidus | 4.32 ± 0.48 | |
| Hypothalamus | 3.44 ± 0.56 | |
| Insula | 3.57 ± 1 | |
| Limbic Lobe | 4.07 ± 0.8 | |
| Mesencephalon | 3.93 ± 0.57 | |
| Myelencephalon | 3.94 ± 0.71 | |
| Occipital Lobe | 4.45 ± 0.58 | |
| Parietal Lobe | 3.97 ± 0.64 | |
| Pontine Tegmentum | 4.02 ± 0.76 | |
| Striatum | 4.56 ± 0.74 | |
| Subthalamus | 4 ± 0.56 | |
| Temporal Lobe | 3.83 ± 0.63 | |
| Thalamus | 3.69 ± 0.67 | |
| White Matter | 4.73 ± 0.71 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Top3b | CB | Cerebellum | 6.78 | |
| 7.75 | | |||
| Top3b | CTX | Cerebral cortex | 17.1 | |
| 12.68 | | |||
| Top3b | HIP | Hippocampal region | 29.54 | |
| 31.29 | | |||
| Top3b | HPF | Hippocampal formation | 25.95 | |
| 25.3 | | |||
| Top3b | HY | Hypothalamus | 19.95 | |
| 16.21 | | |||
| Top3b | LSX | Lateral septal complex | 5.03 | |
| 3.55 | | |||
| Top3b | MB | Midbrain | 4.11 | |
| 4.45 | | |||
| Top3b | MY | Medulla | 11 | |
| 12.96 | | |||
| Top3b | OLF | Olfactory bulb | 35.41 | |
| 27.74 | | |||
| Top3b | P | Pons | 17.1 | |
| 19.85 | | |||
| Top3b | PAL | Pallidum | 6.48 | |
| 5.39 | | |||
| Top3b | RHP | Retrohippocampal region | 16.35 | |
| 13.71 | | |||
| Top3b | sAMY | Striatum-like amygdalar nuclei | 9.83 | |
| 7.24 | | |||
| Top3b | STR | Striatum | 7.65 | |
| 5.88 | | |||
| Top3b | STRd | Striatum dorsal region | 4.16 | |
| 3.26 | | |||
| Top3b | STRv | Striatum ventral region | 20.77 | |
| 15.27 | | |||
| Top3b | TH | Thalamus | 6.52 | |
| 5.64 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| PAp00025683 | 19 | 506 | 524 | HGIGTDASIPVHINNICQR | Peptide Atlas |
| TOP3B_HUMAN_296 | 13 | 296 | 308 | QRPLALNTVEMLR | PRIDE |