AutismKB 2.0

Annotation Detail for KYNU


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Basic Information Top
Gene Symbol:KYNU ( - )
Gene Full Name: kynureninase (L-kynurenine hydrolase)
Band: 2q22.2
Quick LinksEntrez ID:8942; OMIM: 605197; Uniprot ID:KYNU_HUMAN; ENSEMBL ID: ENSG00000115919; HGNC ID: 6469
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus23 / 56401240
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult115 / 193912159
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor2 / 9417821
cervical tumor8 / 34366232
chondrosarcoma10 / 82823120
colorectal tumor2 / 11424617
esophageal tumor1 / 1729057
gastrointestinal tumor5 / 11936941
germ cell tumor1 / 2638453
glioma5 / 10688346
head and neck tumor3 / 13630222
kidney tumor1 / 6895914
leukemia5 / 9584252
liver tumor9 / 9635993
lung tumor4 / 10312738
lymphoma2 / 7175527
non-neoplasia3 / 9725030
normal139 / 336030741
ovarian tumor0 / 766820 
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor9 / 12494972
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor26 / 90257288
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites4 / 4001599
bladder1 / 2975733
blood7 / 12347856
bone7 / 7165597
bone marrow5 / 48801102
brain6 / 11009895
cervix8 / 48171166
connective tissue10 / 14925566
ear2 / 16212123
embryonic tissue1 / 2157224
esophagus2 / 2020998
eye1 / 2110544
heart0 / 896260 
intestine3 / 23447212
kidney18 / 21177784
larynx2 / 2414582
liver20 / 20774396
lung22 / 33697465
lymph0 / 442700 
lymph node8 / 9161087
mammary gland8 / 15327152
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx12 / 41328290
pituitary gland0 / 165850 
placenta30 / 280825106
prostate1 / 1893455
salivary gland0 / 201550 
skin9 / 21057442
spleen0 / 539520 
stomach1 / 9661910
testis13 / 33044239
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus26 / 232878111
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204385_at
Cell line Expression level Expression bar
721_B_lymphoblasts211.45
Adipocyte16
AdrenalCortex18.35
Adrenalgland18.65
Amygdala15.7
Appendix43.5
AtrioventricularNode45.05
BDCA4+_DentriticCells89.75
Bonemarrow27.65
BronchialEpithelialCells136.2
CD105+_Endothelial22.65
CD14+_Monocytes140.7
CD19+_BCells(neg._sel.)53.9
CD33+_Myeloid95.55
CD34+31.7
CD4+_Tcells17.5
CD56+_NKCells22.05
CD71+_EarlyErythroid48.35
CD8+_Tcells14.7
CardiacMyocytes21.7
Caudatenucleus15.45
Cerebellum15.55
CerebellumPeduncles22.3
CiliaryGanglion26.85
CingulateCortex23.45
Colorectaladenocarcinoma16.75
DorsalRootGanglion66.15
FetalThyroid21.4
Fetalbrain16.65
Fetalliver31.2
Fetallung15.55
GlobusPallidus21.15
Heart23.3
Hypothalamus14.15
Kidney16.85
Leukemia_chronicMyelogenousK-56218.1
Leukemia_promyelocytic-HL-6017.7
Leukemialymphoblastic(MOLT-4)14.8
Liver33.05
Lung17.75
Lymphnode16.05
Lymphoma_burkitts(Daudi)27
Lymphoma_burkitts(Raji)22.45
MedullaOblongata16.45
OccipitalLobe12.7
OlfactoryBulb17.05
Ovary23.25
Pancreas19.85
PancreaticIslet21.15
ParietalLobe20
Pituitary19.35
Placenta18.15
Pons21.9
PrefrontalCortex14.95
Prostate22.15
Salivarygland31.2
SkeletalMuscle47.35
Skin56
SmoothMuscle19.7
Spinalcord20.05
SubthalamicNucleus24.35
SuperiorCervicalGanglion63.4
TemporalLobe21.85
Testis20.8
TestisGermCell18.25
TestisIntersitial22.95
TestisLeydigCell42.1
TestisSeminiferousTubule19.65
Thalamus19.35
Thymus12.2
Thyroid14.75
Tongue28.05
Tonsil22.8
Trachea15.75
TrigeminalGanglion46.1
Uterus13.1
UterusCorpus18.4
WholeBlood20.85
Wholebrain12.75
colon9
pineal_day20.68
pineal_night17.16
retina15.775
small_intestine9.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P56898
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.59 ± 0.79
Basal Forebrain3.83 ± 0.61
Basal Part of Pons3.62 ± 0.36
Cerebellar Cortex3 ± 0.66
Cerebellar Nuclei4.35 ± 0.55
Claustrum4.17 ± 0.8
Epithalamus3.58 ± 0.94
Frontal Lobe3.96 ± 0.59
Globus Pallidus3.85 ± 0.34
Hypothalamus3.75 ± 0.59
Insula3.73 ± 0.7
Limbic Lobe3.42 ± 0.72
Mesencephalon3.58 ± 0.78
Myelencephalon3.67 ± 0.77
Occipital Lobe2.88 ± 0.71
Parietal Lobe3.33 ± 0.75
Pontine Tegmentum3.53 ± 0.79
Striatum4.77 ± 0.43
Subthalamus3.9 ± 0.52
Temporal Lobe3.21 ± 0.72
Thalamus3.22 ± 0.66
White Matter3.28 ± 0.73
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
KynuCBCerebellum100
100
KynuCTXCerebral cortex100
100
KynuHIPHippocampal region100
100
KynuHPFHippocampal formation100
100
KynuHYHypothalamus100
100
KynuLSXLateral septal complex100
100
KynuMBMidbrain100
100
KynuMYMedulla100
100
KynuOLFOlfactory bulb100
100
KynuPPons100
100
KynuPALPallidum100
100
KynuRHPRetrohippocampal region100
100
KynusAMYStriatum-like amygdalar nuclei100
100
KynuSTRStriatum100
100
KynuSTRdStriatum dorsal region100
100
KynuSTRvStriatum ventral region100
100
KynuTHThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
KYNU_HUMAN_0 0 0 0 VALHLDEEDKLR PRIDE
KYNU_HUMAN_386 14 386 399 PVVNIITPSHVEER PRIDE
PAp00035397 15 385 399 KPVVNIITPSHVEER Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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