AutismKB 2.0

Annotation Detail for USP13


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Basic Information Top
Gene Symbol:USP13 ( ISOT3,IsoT-3 )
Gene Full Name: ubiquitin specific peptidase 13 (isopeptidase T-3)
Band: 3q26.33
Quick LinksEntrez ID:8975; OMIM: 603591; Uniprot ID:UBP13_HUMAN; ENSEMBL ID: ENSG00000058056; HGNC ID: 12611
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst1 / 6231916
fetus26 / 56401246
neonate0 / 310970 
infant1 / 2362042
juvenile1 / 5555617
adult67 / 193912134
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor8 / 9417884
cervical tumor12 / 34366349
chondrosarcoma5 / 8282360
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor9 / 26384534
glioma3 / 10688328
head and neck tumor6 / 13630244
kidney tumor0 / 689590 
leukemia5 / 9584252
liver tumor0 / 963590 
lung tumor3 / 10312729
lymphoma5 / 7175569
non-neoplasia1 / 9725010
normal95 / 336030728
ovarian tumor1 / 7668213
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer2 / 10268019
retinoblastoma2 / 4635643
skin tumor5 / 12494940
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites1 / 4001524
bladder0 / 297570 
blood1 / 1234788
bone5 / 7165569
bone marrow1 / 4880120
brain12 / 110098910
cervix14 / 48171290
connective tissue5 / 14925533
ear1 / 1621261
embryonic tissue4 / 21572218
esophagus0 / 202090 
eye5 / 21105423
heart6 / 8962666
intestine1 / 2344724
kidney2 / 2117779
larynx4 / 24145165
liver7 / 20774333
lung10 / 33697429
lymph1 / 4427022
lymph node2 / 9161021
mammary gland10 / 15327165
mouth2 / 6705229
muscle13 / 107715120
nerve0 / 157680 
ovary2 / 10205119
pancreas9 / 21481241
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate7 / 18934536
salivary gland0 / 201550 
skin9 / 21057442
spleen0 / 539520 
stomach1 / 9661910
testis16 / 33044248
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus6 / 23287825
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205356_at
Cell line Expression level Expression bar
721_B_lymphoblasts69.4
Adipocyte7.1
AdrenalCortex22.6
Adrenalgland52.5
Amygdala6.65
Appendix6.4
AtrioventricularNode4.95
BDCA4+_DentriticCells10.75
Bonemarrow6.55
BronchialEpithelialCells6.35
CD105+_Endothelial5.05
CD14+_Monocytes6.3
CD19+_BCells(neg._sel.)6
CD33+_Myeloid7
CD34+8.4
CD4+_Tcells6.85
CD56+_NKCells6.4
CD71+_EarlyErythroid5.4
CD8+_Tcells7.4
CardiacMyocytes9.7
Caudatenucleus5.7
Cerebellum5.85
CerebellumPeduncles8.4
CiliaryGanglion5.75
CingulateCortex7.25
Colorectaladenocarcinoma8.1
DorsalRootGanglion5.5
FetalThyroid18.95
Fetalbrain7.85
Fetalliver5.7
Fetallung8.25
GlobusPallidus5.45
Heart17.25
Hypothalamus7.45
Kidney5.55
Leukemia_chronicMyelogenousK-5625.8
Leukemia_promyelocytic-HL-6012.45
Leukemialymphoblastic(MOLT-4)11.55
Liver8.65
Lung8.55
Lymphnode5.55
Lymphoma_burkitts(Daudi)28.6
Lymphoma_burkitts(Raji)9.25
MedullaOblongata7
OccipitalLobe7
OlfactoryBulb5.6
Ovary4.55
Pancreas5.35
PancreaticIslet7.05
ParietalLobe7.35
Pituitary48.3
Placenta7
Pons6.4
PrefrontalCortex10.7
Prostate15.95
Salivarygland5.2
SkeletalMuscle281
Skin5.35
SmoothMuscle8.6
Spinalcord7.05
SubthalamicNucleus7.45
SuperiorCervicalGanglion8.9
TemporalLobe6.2
Testis27.55
TestisGermCell51.45
TestisIntersitial8.7
TestisLeydigCell14.6
TestisSeminiferousTubule16.7
Thalamus6.5
Thymus6.9
Thyroid15.25
Tongue34.75
Tonsil7.35
Trachea5.35
TrigeminalGanglion6.6
Uterus7.5
UterusCorpus6.15
WholeBlood6.95
Wholebrain5.5
colon6.5
pineal_day46.12
pineal_night108.36
retina9.3
small_intestine6.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16514_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.51 ± 0.57
Basal Forebrain6.14 ± 0.1
Basal Part of Pons5.72 ± 0.36
Cerebellar Cortex6.22 ± 0.14
Cerebellar Nuclei5.92 ± 0.23
Claustrum5.33 ± 0.65
Epithalamus5.74 ± 0.52
Frontal Lobe5.76 ± 0.35
Globus Pallidus6.02 ± 0.18
Hypothalamus6.13 ± 0.26
Insula5.64 ± 0.28
Limbic Lobe5.62 ± 0.42
Mesencephalon5.97 ± 0.38
Myelencephalon5.87 ± 0.39
Occipital Lobe6.27 ± 0.33
Parietal Lobe5.93 ± 0.32
Pontine Tegmentum5.95 ± 0.41
Striatum5.63 ± 0.35
Subthalamus5.72 ± 0.12
Temporal Lobe5.87 ± 0.31
Thalamus6.16 ± 0.24
White Matter7.13 ± 0.18
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Usp13CBCerebellum6.65
7.03
Usp13CTXCerebral cortex19.46
11.31
Usp13HIPHippocampal region8.66
9.03
Usp13HPFHippocampal formation11.46
10.31
Usp13HYHypothalamus14.63
10.54
Usp13LSXLateral septal complex12.1
4.82
Usp13MBMidbrain5.27
4.06
Usp13MYMedulla7.89
6.9
Usp13OLFOlfactory bulb22.19
14.17
Usp13PPons7.11
5.88
Usp13PALPallidum13.07
8.37
Usp13RHPRetrohippocampal region16.34
12.3
Usp13sAMYStriatum-like amygdalar nuclei6.7
4.05
Usp13STRStriatum10.07
5.67
Usp13STRdStriatum dorsal region7.77
4.15
Usp13STRvStriatum ventral region19.84
11.91
Usp13THThalamus10.05
7.22
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
UBP13_HUMAN_19 18 19 36 MAAGDIGELLVPHMPTIR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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