AutismKB 2.0

Annotation Detail for PLOD3


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Basic Information Top
Gene Symbol:PLOD3 ( LH3 )
Gene Full Name: procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
Band: 7q22.1
Quick LinksEntrez ID:8985; OMIM: 603066; Uniprot ID:PLOD3_HUMAN; ENSEMBL ID: ENSG00000106397; HGNC ID: 9083
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body8 / 70761113
blastocyst9 / 62319144
fetus61 / 564012108
neonate24 / 31097771
infant0 / 236200 
juvenile21 / 55556377
adult281 / 1939121144
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma1 / 1747557
breast (mammary gland) tumor19 / 94178201
cervical tumor0 / 343660 
chondrosarcoma18 / 82823217
colorectal tumor21 / 114246183
esophageal tumor2 / 17290115
gastrointestinal tumor56 / 119369469
germ cell tumor55 / 263845208
glioma34 / 106883318
head and neck tumor22 / 136302161
kidney tumor9 / 68959130
leukemia11 / 95842114
liver tumor12 / 96359124
lung tumor5 / 10312748
lymphoma1 / 7175513
non-neoplasia11 / 97250113
normal415 / 3360307123
ovarian tumor25 / 76682326
pancreatic tumor10 / 10461695
primitive neuroectodermal tumor of the CNS41 / 125680326
prostate cancer10 / 10268097
retinoblastoma2 / 4635643
skin tumor28 / 124949224
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland9 / 33197271
ascites43 / 400151074
bladder0 / 297570 
blood11 / 12347889
bone14 / 71655195
bone marrow6 / 48801122
brain165 / 1100989149
cervix4 / 4817183
connective tissue30 / 149255200
ear0 / 162120 
embryonic tissue22 / 215722101
esophagus2 / 2020998
eye13 / 21105461
heart7 / 8962678
intestine40 / 234472170
kidney40 / 211777188
larynx0 / 241450 
liver17 / 20774381
lung39 / 336974115
lymph1 / 4427022
lymph node7 / 9161076
mammary gland23 / 153271150
mouth16 / 67052238
muscle5 / 10771546
nerve1 / 1576863
ovary27 / 102051264
pancreas29 / 214812135
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta41 / 280825145
prostate21 / 189345110
salivary gland1 / 2015549
skin68 / 210574322
spleen17 / 53952315
stomach8 / 9661982
testis30 / 33044290
thymus10 / 81131123
thyroid11 / 47473231
tonsil2 / 16999117
trachea2 / 5241338
umbilical cord4 / 13680292
uterus13 / 23287855
vascular20 / 51780386
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202185_at
Cell line Expression level Expression bar
721_B_lymphoblasts44
Adipocyte112.1
AdrenalCortex72.45
Adrenalgland58.6
Amygdala48.1
Appendix72.95
AtrioventricularNode49.8
BDCA4+_DentriticCells104.05
Bonemarrow50.5
BronchialEpithelialCells96.9
CD105+_Endothelial74.1
CD14+_Monocytes107.7
CD19+_BCells(neg._sel.)51.8
CD33+_Myeloid169.95
CD34+103.7
CD4+_Tcells67.65
CD56+_NKCells94.45
CD71+_EarlyErythroid140.25
CD8+_Tcells53.85
CardiacMyocytes162.75
Caudatenucleus59.45
Cerebellum45.05
CerebellumPeduncles53.55
CiliaryGanglion43.6
CingulateCortex73.1
Colorectaladenocarcinoma367.75
DorsalRootGanglion51.8
FetalThyroid113.7
Fetalbrain42.1
Fetalliver51.55
Fetallung78.3
GlobusPallidus32.6
Heart107.05
Hypothalamus86.7
Kidney53.95
Leukemia_chronicMyelogenousK-562121.4
Leukemia_promyelocytic-HL-6032.15
Leukemialymphoblastic(MOLT-4)42.65
Liver227.1
Lung160.6
Lymphnode75.8
Lymphoma_burkitts(Daudi)55.6
Lymphoma_burkitts(Raji)117.35
MedullaOblongata58.3
OccipitalLobe44.1
OlfactoryBulb210.4
Ovary43.15
Pancreas94.55
PancreaticIslet77
ParietalLobe75.95
Pituitary79.25
Placenta272.85
Pons46.25
PrefrontalCortex64.95
Prostate73.55
Salivarygland23.45
SkeletalMuscle55.7
Skin32.85
SmoothMuscle167.05
Spinalcord145.55
SubthalamicNucleus29.75
SuperiorCervicalGanglion81.95
TemporalLobe48.2
Testis60.4
TestisGermCell56.75
TestisIntersitial53.95
TestisLeydigCell43.4
TestisSeminiferousTubule61.1
Thalamus74.15
Thymus48.2
Thyroid103.8
Tongue49.2
Tonsil58.05
Trachea34.5
TrigeminalGanglion78.35
Uterus102.45
UterusCorpus98.65
WholeBlood49.25
Wholebrain63.5
colon55.15
pineal_day40.5
pineal_night25.42
retina129.325
small_intestine51.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9309_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.31 ± 0.68
Basal Forebrain3.39 ± 0.54
Basal Part of Pons3.7 ± 0.69
Cerebellar Cortex3.48 ± 0.56
Cerebellar Nuclei3.95 ± 0.84
Claustrum3.2 ± 0.7
Epithalamus3.91 ± 0.53
Frontal Lobe3.56 ± 0.73
Globus Pallidus4.59 ± 0.31
Hypothalamus3.69 ± 0.77
Insula3.1 ± 0.62
Limbic Lobe3.18 ± 0.52
Mesencephalon3.46 ± 0.75
Myelencephalon3.53 ± 0.6
Occipital Lobe3.58 ± 0.73
Parietal Lobe3.45 ± 0.58
Pontine Tegmentum3.66 ± 0.58
Striatum3.5 ± 0.6
Subthalamus3.33 ± 0.24
Temporal Lobe3.41 ± 0.57
Thalamus3.93 ± 0.51
White Matter5.85 ± 0.29
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Plod3CBCerebellum9.7
9.89
Plod3CTXCerebral cortex12.97
8.64
Plod3HIPHippocampal region17.68
16.91
Plod3HPFHippocampal formation16.58
13.94
Plod3HYHypothalamus4.75
3.69
Plod3LSXLateral septal complex2.22
1.62
Plod3MBMidbrain8.12
6.8
Plod3MYMedulla15.19
15.1
Plod3OLFOlfactory bulb13.03
9.02
Plod3PPons11.31
11.61
Plod3PALPallidum5.8
4.49
Plod3RHPRetrohippocampal region15.95
11.14
Plod3sAMYStriatum-like amygdalar nuclei3.27
1.88
Plod3STRStriatum4.24
3.06
Plod3STRdStriatum dorsal region4.13
3.12
Plod3STRvStriatum ventral region5.54
3.66
Plod3THThalamus8.22
5.89
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00001833 16 480 495 DVFSGSDTDPDMAFCK Peptide Atlas
PLOD3_HUMAN_648 8 648 655 AVMNFVVR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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