AutismKB 2.0

Annotation Detail for KLHL6


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Basic Information Top
Gene Symbol:KLHL6 ( FLJ00029 )
Gene Full Name: kelch-like 6 (Drosophila)
Band: 3q27.1
Quick LinksEntrez ID:89857; OMIM: NA; Uniprot ID:KLHL6_HUMAN; ENSEMBL ID: ENSG00000172578; HGNC ID: 18653
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus4 / 5640127
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult17 / 19391218
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor0 / 1142460 
esophageal tumor1 / 1729057
gastrointestinal tumor0 / 1193690 
germ cell tumor2 / 2638457
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia4 / 9584241
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma9 / 71755125
non-neoplasia1 / 9725010
normal53 / 336030715
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood2 / 12347816
bone0 / 716550 
bone marrow4 / 4880181
brain6 / 11009895
cervix0 / 481710 
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus1 / 2020949
eye0 / 2110540 
heart0 / 896260 
intestine3 / 23447212
kidney3 / 21177714
larynx0 / 241450 
liver0 / 2077430 
lung5 / 33697414
lymph6 / 44270135
lymph node27 / 91610294
mammary gland0 / 1532710 
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary0 / 1020510 
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen2 / 5395237
stomach0 / 966190 
testis0 / 3304420 
thymus10 / 81131123
thyroid0 / 474730 
tonsil2 / 16999117
trachea3 / 5241357
umbilical cord0 / 136800 
uterus3 / 23287812
vascular4 / 5178077
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P944253
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.12 ± 1.05
Basal Forebrain1.52 ± 0.21
Basal Part of Pons1.54 ± 0.59
Cerebellar Cortex1.49 ± 0.55
Cerebellar Nuclei2.4 ± 0.63
Claustrum2.45 ± 0.84
Epithalamus1.77 ± 0.8
Frontal Lobe1.57 ± 0.72
Globus Pallidus3 ± 0.69
Hypothalamus1.58 ± 0.7
Insula1.88 ± 0.73
Limbic Lobe1.7 ± 0.68
Mesencephalon1.89 ± 0.73
Myelencephalon1.76 ± 0.67
Occipital Lobe1.79 ± 0.65
Parietal Lobe1.71 ± 0.67
Pontine Tegmentum1.79 ± 0.69
Striatum1.81 ± 0.55
Subthalamus1.91 ± 0.85
Temporal Lobe1.66 ± 0.71
Thalamus1.64 ± 0.55
White Matter2.94 ± 0.28
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Klhl6CBCerebellum5.33
6.25
Klhl6CTXCerebral cortex7.09
5.14
Klhl6HIPHippocampal region3.76
3.72
Klhl6HPFHippocampal formation3.83
3.31
Klhl6HYHypothalamus0.21
0.22
Klhl6LSXLateral septal complex0.34
0.19
Klhl6MBMidbrain1.4
2.01
Klhl6MYMedulla2.49
2.76
Klhl6OLFOlfactory bulb3.48
3.89
Klhl6PPons0.56
0.85
Klhl6PALPallidum0.83
1.05
Klhl6RHPRetrohippocampal region4.07
2.83
Klhl6sAMYStriatum-like amygdalar nuclei0.84
0.7
Klhl6STRStriatum1.4
1.15
Klhl6STRdStriatum dorsal region1.56
1.21
Klhl6STRvStriatum ventral region1.56
1.57
Klhl6THThalamus4.78
5.78
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018