AutismKB 2.0

Annotation Detail for CCNF


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Basic Information Top
Gene Symbol:CCNF ( FBX1,FBXO1 )
Gene Full Name: cyclin F
Band: 16p13.3
Quick LinksEntrez ID:899; OMIM: 600227; Uniprot ID:CCNF_HUMAN; ENSEMBL ID: ENSG00000162063; HGNC ID: 1591
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst2 / 6231932
fetus8 / 56401214
neonate0 / 310970 
infant1 / 2362042
juvenile2 / 5555635
adult26 / 193912113
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor7 / 9417874
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor10 / 26384537
glioma1 / 1068839
head and neck tumor4 / 13630229
kidney tumor5 / 6895972
leukemia3 / 9584231
liver tumor0 / 963590 
lung tumor3 / 10312729
lymphoma5 / 7175569
non-neoplasia0 / 972500 
normal54 / 336030716
ovarian tumor2 / 7668226
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer0 / 1026800 
retinoblastoma5 / 46356107
skin tumor2 / 12494916
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder1 / 2975733
blood3 / 12347824
bone1 / 7165513
bone marrow0 / 488010 
brain14 / 110098912
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue14 / 21572264
esophagus0 / 202090 
eye7 / 21105433
heart0 / 896260 
intestine3 / 23447212
kidney5 / 21177723
larynx1 / 2414541
liver3 / 20774314
lung7 / 33697420
lymph5 / 44270112
lymph node5 / 9161054
mammary gland8 / 15327152
mouth1 / 6705214
muscle3 / 10771527
nerve0 / 157680 
ovary4 / 10205139
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta1 / 2808253
prostate0 / 1893450 
salivary gland0 / 201550 
skin3 / 21057414
spleen2 / 5395237
stomach1 / 9661910
testis5 / 33044215
thymus7 / 8113186
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus4 / 23287817
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204826_at
Cell line Expression level Expression bar
721_B_lymphoblasts72.15
Adipocyte8.9
AdrenalCortex9.5
Adrenalgland5.65
Amygdala4.9
Appendix7.4
AtrioventricularNode13.45
BDCA4+_DentriticCells7.85
Bonemarrow19.3
BronchialEpithelialCells7
CD105+_Endothelial110.1
CD14+_Monocytes6.3
CD19+_BCells(neg._sel.)9.1
CD33+_Myeloid11.65
CD34+28.1
CD4+_Tcells8.3
CD56+_NKCells13.25
CD71+_EarlyErythroid143.85
CD8+_Tcells7.05
CardiacMyocytes19.85
Caudatenucleus6.85
Cerebellum6.7
CerebellumPeduncles12.9
CiliaryGanglion9.3
CingulateCortex7.45
Colorectaladenocarcinoma7.25
DorsalRootGanglion5.6
FetalThyroid8.15
Fetalbrain8.9
Fetalliver15.65
Fetallung5.55
GlobusPallidus12.5
Heart8.65
Hypothalamus7.8
Kidney6.15
Leukemia_chronicMyelogenousK-56218.65
Leukemia_promyelocytic-HL-608.15
Leukemialymphoblastic(MOLT-4)49.35
Liver8.6
Lung6.65
Lymphnode6.25
Lymphoma_burkitts(Daudi)18.75
Lymphoma_burkitts(Raji)10.15
MedullaOblongata7.25
OccipitalLobe6.4
OlfactoryBulb6.8
Ovary4.95
Pancreas6.8
PancreaticIslet9.6
ParietalLobe7.85
Pituitary8.55
Placenta7.2
Pons8.6
PrefrontalCortex7.95
Prostate6.7
Salivarygland5.9
SkeletalMuscle11.4
Skin5.8
SmoothMuscle7.35
Spinalcord8.45
SubthalamicNucleus7.65
SuperiorCervicalGanglion10.8
TemporalLobe13.6
Testis6.3
TestisGermCell5.9
TestisIntersitial5.7
TestisLeydigCell7.3
TestisSeminiferousTubule6.9
Thalamus7.45
Thymus15.1
Thyroid3.4
Tongue8.35
Tonsil8.65
Trachea5.7
TrigeminalGanglion12
Uterus4.15
UterusCorpus6.55
WholeBlood5.55
Wholebrain4.85
colon3.2
pineal_day9.4
pineal_night11.06
retina5.05
small_intestine2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P37954
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.69 ± 0.81
Basal Forebrain3.03 ± 0.68
Basal Part of Pons3.42 ± 0.47
Cerebellar Cortex3.99 ± 0.43
Cerebellar Nuclei3.35 ± 0.59
Claustrum3.69 ± 0.52
Epithalamus3.01 ± 0.62
Frontal Lobe3.61 ± 0.48
Globus Pallidus2.44 ± 0.56
Hypothalamus3.49 ± 0.47
Insula3.6 ± 0.4
Limbic Lobe3.59 ± 0.59
Mesencephalon3.58 ± 0.58
Myelencephalon3.58 ± 0.62
Occipital Lobe3.37 ± 0.65
Parietal Lobe3.56 ± 0.59
Pontine Tegmentum3.47 ± 0.62
Striatum2.71 ± 0.71
Subthalamus3.52 ± 0.13
Temporal Lobe3.74 ± 0.49
Thalamus3.57 ± 0.56
White Matter2.94 ± 0.47
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
CcnfCBCerebellum11.45
11.32
CcnfCTXCerebral cortex15.86
10.8
CcnfHIPHippocampal region14.38
12.86
CcnfHPFHippocampal formation13.1
10.74
CcnfHYHypothalamus10.9
7.79
CcnfLSXLateral septal complex9.05
8.11
CcnfMBMidbrain2.44
2.23
CcnfMYMedulla3.87
3.44
CcnfOLFOlfactory bulb28.63
21.4
CcnfPPons3.38
3.24
CcnfPALPallidum7.8
6.1
CcnfRHPRetrohippocampal region11.31
8.04
CcnfsAMYStriatum-like amygdalar nuclei6.74
4.13
CcnfSTRStriatum6.9
5.32
CcnfSTRdStriatum dorsal region4.34
3.31
CcnfSTRvStriatum ventral region17.47
13.22
CcnfTHThalamus5.47
4.06
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
CCNF_HUMAN_507 10 507 516 QVSLTAVKQR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018