AutismKB 2.0

Annotation Detail for KALRN


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Basic Information Top
Gene Symbol:KALRN ( ARHGEF24,DUET,DUO,FLJ12332,FLJ16443,FLJ18196,FLJ18623,HAPIP,TRAD )
Gene Full Name: kalirin, RhoGEF kinase
Band: 3q21.1-q21.2
Quick LinksEntrez ID:8997; OMIM: 604605; Uniprot ID:KALRN_HUMAN; ENSEMBL ID: ENSG00000160145; HGNC ID: 4814
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst2 / 6231932
fetus26 / 56401246
neonate2 / 3109764
infant1 / 2362042
juvenile0 / 555560 
adult84 / 193912143
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor5 / 11424643
esophageal tumor1 / 1729057
gastrointestinal tumor5 / 11936941
germ cell tumor6 / 26384522
glioma2 / 10688318
head and neck tumor5 / 13630236
kidney tumor5 / 6895972
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal204 / 336030760
ovarian tumor3 / 7668239
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites4 / 4001599
bladder0 / 297570 
blood2 / 12347816
bone0 / 716550 
bone marrow0 / 488010 
brain102 / 110098992
cervix0 / 481710 
connective tissue4 / 14925526
ear1 / 1621261
embryonic tissue3 / 21572213
esophagus1 / 2020949
eye16 / 21105475
heart0 / 896260 
intestine12 / 23447251
kidney6 / 21177728
larynx0 / 241450 
liver3 / 20774314
lung3 / 3369748
lymph0 / 442700 
lymph node0 / 916100 
mammary gland9 / 15327158
mouth1 / 6705214
muscle3 / 10771527
nerve0 / 157680 
ovary1 / 1020519
pancreas1 / 2148124
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta10 / 28082535
prostate3 / 18934515
salivary gland2 / 2015599
skin1 / 2105744
spleen4 / 5395274
stomach1 / 9661910
testis24 / 33044272
thymus1 / 8113112
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus11 / 23287847
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205635_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.25
Adipocyte5.2
AdrenalCortex5.9
Adrenalgland4.55
Amygdala99.95
Appendix5.95
AtrioventricularNode4.75
BDCA4+_DentriticCells5.35
Bonemarrow5.6
BronchialEpithelialCells5.15
CD105+_Endothelial5.25
CD14+_Monocytes5.5
CD19+_BCells(neg._sel.)5.55
CD33+_Myeloid6.5
CD34+6.4
CD4+_Tcells5.45
CD56+_NKCells6.3
CD71+_EarlyErythroid4.95
CD8+_Tcells4.9
CardiacMyocytes7.5
Caudatenucleus29.15
Cerebellum4.4
CerebellumPeduncles6.45
CiliaryGanglion4.05
CingulateCortex85.25
Colorectaladenocarcinoma5.4
DorsalRootGanglion5.05
FetalThyroid5.1
Fetalbrain22.1
Fetalliver4.7
Fetallung4.2
GlobusPallidus93.55
Heart7.4
Hypothalamus5.75
Kidney4.45
Leukemia_chronicMyelogenousK-5624.9
Leukemia_promyelocytic-HL-604.85
Leukemialymphoblastic(MOLT-4)4.15
Liver7.7
Lung7.05
Lymphnode4.8
Lymphoma_burkitts(Daudi)6.8
Lymphoma_burkitts(Raji)7.9
MedullaOblongata83.15
OccipitalLobe100.6
OlfactoryBulb4.15
Ovary3.65
Pancreas4.4
PancreaticIslet5.65
ParietalLobe119.2
Pituitary6.15
Placenta5.3
Pons69.9
PrefrontalCortex163.65
Prostate6.1
Salivarygland4.3
SkeletalMuscle6.95
Skin4.5
SmoothMuscle5.9
Spinalcord5.7
SubthalamicNucleus78.95
SuperiorCervicalGanglion6.6
TemporalLobe38.45
Testis4.5
TestisGermCell5.05
TestisIntersitial4.55
TestisLeydigCell5.45
TestisSeminiferousTubule4.5
Thalamus9.7
Thymus4.1
Thyroid6.5
Tongue5.45
Tonsil5.15
Trachea4.35
TrigeminalGanglion5.6
Uterus4.35
UterusCorpus4.95
WholeBlood5.7
Wholebrain225.45
colon5.3
pineal_day10.1
pineal_night6.86
retina6.4
small_intestine5.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P328524
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala10.96 ± 1.17
Basal Forebrain9.34 ± 0.67
Basal Part of Pons10.65 ± 0.53
Cerebellar Cortex8.99 ± 0.42
Cerebellar Nuclei7.13 ± 1.34
Claustrum11.37 ± 0.59
Epithalamus8.12 ± 0.93
Frontal Lobe10.3 ± 0.72
Globus Pallidus6.14 ± 2.05
Hypothalamus8.22 ± 1.16
Insula10.55 ± 0.39
Limbic Lobe10.9 ± 1.1
Mesencephalon8.8 ± 0.97
Myelencephalon9.66 ± 0.95
Occipital Lobe10.16 ± 0.61
Parietal Lobe10.19 ± 0.89
Pontine Tegmentum9.68 ± 1.1
Striatum8.71 ± 2.22
Subthalamus9.98 ± 0.47
Temporal Lobe10.47 ± 0.59
Thalamus9.58 ± 0.92
White Matter7.28 ± 1.68
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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