AutismKB 2.0

Annotation Detail for TSR2


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Basic Information Top
Gene Symbol:TSR2 ( DT1P1A10,MGC20451,WGG1 )
Gene Full Name: TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
Band: Xp11.22
Quick LinksEntrez ID:90121; OMIM: NA; Uniprot ID:TSR2_HUMAN; ENSEMBL ID: ENSG00000158526; HGNC ID: 25455
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst1 / 6231916
fetus14 / 56401224
neonate0 / 310970 
infant1 / 2362042
juvenile1 / 5555617
adult77 / 193912139
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor3 / 3436687
chondrosarcoma4 / 8282348
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor7 / 11936958
germ cell tumor9 / 26384534
glioma16 / 106883149
head and neck tumor3 / 13630222
kidney tumor2 / 6895929
leukemia5 / 9584252
liver tumor1 / 9635910
lung tumor0 / 1031270 
lymphoma2 / 7175527
non-neoplasia1 / 9725010
normal99 / 336030729
ovarian tumor6 / 7668278
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer7 / 10268068
retinoblastoma3 / 4635664
skin tumor9 / 12494972
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites4 / 4001599
bladder2 / 2975767
blood6 / 12347848
bone0 / 716550 
bone marrow2 / 4880140
brain41 / 110098937
cervix6 / 48171124
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue10 / 21572246
esophagus0 / 202090 
eye14 / 21105466
heart1 / 8962611
intestine7 / 23447229
kidney7 / 21177733
larynx2 / 2414582
liver1 / 2077434
lung9 / 33697426
lymph1 / 4427022
lymph node1 / 9161010
mammary gland3 / 15327119
mouth1 / 6705214
muscle1 / 1077159
nerve0 / 157680 
ovary10 / 10205197
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta6 / 28082521
prostate9 / 18934547
salivary gland0 / 201550 
skin15 / 21057471
spleen0 / 539520 
stomach2 / 9661920
testis10 / 33044230
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus9 / 23287838
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 213079_at
Cell line Expression level Expression bar
721_B_lymphoblasts144.45
Adipocyte49.85
AdrenalCortex55.05
Adrenalgland50.15
Amygdala70.6
Appendix76.1
AtrioventricularNode41.35
BDCA4+_DentriticCells108.75
Bonemarrow60.55
BronchialEpithelialCells48.85
CD105+_Endothelial69.05
CD14+_Monocytes73.75
CD19+_BCells(neg._sel.)152.4
CD33+_Myeloid81.8
CD34+93.65
CD4+_Tcells206.4
CD56+_NKCells130.95
CD71+_EarlyErythroid89.85
CD8+_Tcells109.55
CardiacMyocytes85.6
Caudatenucleus93
Cerebellum109.6
CerebellumPeduncles187
CiliaryGanglion40.65
CingulateCortex198.8
Colorectaladenocarcinoma72.7
DorsalRootGanglion62.65
FetalThyroid70.6
Fetalbrain52.8
Fetalliver40.5
Fetallung40
GlobusPallidus114
Heart63.3
Hypothalamus259
Kidney48.4
Leukemia_chronicMyelogenousK-56245.35
Leukemia_promyelocytic-HL-6046
Leukemialymphoblastic(MOLT-4)81.75
Liver47.5
Lung63.95
Lymphnode52.95
Lymphoma_burkitts(Daudi)65.1
Lymphoma_burkitts(Raji)63
MedullaOblongata129.75
OccipitalLobe152.6
OlfactoryBulb92.9
Ovary30.7
Pancreas43.1
PancreaticIslet54.8
ParietalLobe114.05
Pituitary128.85
Placenta69.85
Pons159.75
PrefrontalCortex354.85
Prostate50.2
Salivarygland43.3
SkeletalMuscle79.4
Skin69.9
SmoothMuscle65.9
Spinalcord175.3
SubthalamicNucleus123.65
SuperiorCervicalGanglion55.5
TemporalLobe138.3
Testis51
TestisGermCell47.4
TestisIntersitial35.4
TestisLeydigCell45.05
TestisSeminiferousTubule44.45
Thalamus179.05
Thymus57.85
Thyroid90.55
Tongue53.3
Tonsil50.55
Trachea52.65
TrigeminalGanglion72.05
Uterus41.95
UterusCorpus51.85
WholeBlood32.2
Wholebrain182.4
colon76.75
pineal_day279.78
pineal_night278.14
retina190.375
small_intestine59.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7471_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.83 ± 0.2
Basal Forebrain9.02 ± 0.14
Basal Part of Pons8.96 ± 0.24
Cerebellar Cortex8.57 ± 0.14
Cerebellar Nuclei8.77 ± 0.2
Claustrum9.21 ± 0.31
Epithalamus8.57 ± 0.41
Frontal Lobe8.78 ± 0.28
Globus Pallidus9.35 ± 0.19
Hypothalamus8.97 ± 0.23
Insula8.84 ± 0.28
Limbic Lobe8.78 ± 0.34
Mesencephalon8.87 ± 0.27
Myelencephalon8.83 ± 0.27
Occipital Lobe8.71 ± 0.26
Parietal Lobe8.87 ± 0.26
Pontine Tegmentum8.79 ± 0.29
Striatum9.05 ± 0.23
Subthalamus8.89 ± 0.28
Temporal Lobe8.85 ± 0.23
Thalamus8.81 ± 0.19
White Matter9.13 ± 0.16
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tsr2CBCerebellum16.31
17.5
Tsr2CTXCerebral cortex61.41
48.87
Tsr2HIPHippocampal region34.89
48.75
Tsr2HPFHippocampal formation34.55
39.76
Tsr2HYHypothalamus59.77
51.29
Tsr2LSXLateral septal complex47.82
34.73
Tsr2MBMidbrain46.74
43.92
Tsr2MYMedulla39.89
44.59
Tsr2OLFOlfactory bulb60.22
50.85
Tsr2PPons41.73
45.29
Tsr2PALPallidum58.5
57.22
Tsr2RHPRetrohippocampal region33.27
26.57
Tsr2sAMYStriatum-like amygdalar nuclei79.43
66.13
Tsr2STRStriatum40.41
30.45
Tsr2STRdStriatum dorsal region31.18
23.21
Tsr2STRvStriatum ventral region45.7
31.32
Tsr2THThalamus48.1
40.34
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00498061 12 45 56 WLGGAVEDYFMR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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