AutismKB 2.0

Annotation Detail for SOCS3


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Basic Information Top
Gene Symbol:SOCS3 ( ATOD4,CIS3,Cish3,MGC71791,SOCS-3,SSI-3,SSI3 )
Gene Full Name: suppressor of cytokine signaling 3
Band: 17q25.3
Quick LinksEntrez ID:9021; OMIM: 604176; Uniprot ID:SOCS3_HUMAN; ENSEMBL ID: ENSG00000184557; HGNC ID: 19391
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst0 / 623190 
fetus0 / 5640120 
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult91 / 193912146
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma10 / 82823120
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor6 / 11936950
germ cell tumor1 / 2638453
glioma3 / 10688328
head and neck tumor3 / 13630222
kidney tumor0 / 689590 
leukemia3 / 9584231
liver tumor3 / 9635931
lung tumor3 / 10312729
lymphoma2 / 7175527
non-neoplasia5 / 9725051
normal104 / 336030730
ovarian tumor12 / 76682156
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor8 / 9025788
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue7 / 13106534
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood11 / 12347889
bone1 / 7165513
bone marrow0 / 488010 
brain6 / 11009895
cervix1 / 4817120
connective tissue17 / 149255113
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus0 / 202090 
eye16 / 21105475
heart2 / 8962622
intestine2 / 2344728
kidney4 / 21177718
larynx0 / 241450 
liver5 / 20774324
lung21 / 33697462
lymph0 / 442700 
lymph node4 / 9161043
mammary gland8 / 15327152
mouth2 / 6705229
muscle0 / 1077150 
nerve1 / 1576863
ovary18 / 102051176
pancreas12 / 21481255
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta9 / 28082532
prostate1 / 1893455
salivary gland1 / 2015549
skin1 / 2105744
spleen0 / 539520 
stomach7 / 9661972
testis1 / 3304423
thymus3 / 8113136
thyroid1 / 4747321
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus8 / 23287834
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206360_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts164.6
Adipocyte186.65
AdrenalCortex259.75
Adrenalgland163.25
Amygdala194.65
Appendix191.55
AtrioventricularNode159.55
BDCA4+_DentriticCells156.6
Bonemarrow203.15
BronchialEpithelialCells191.8
CD105+_Endothelial186.85
CD14+_Monocytes203.15
CD19+_BCells(neg._sel.)150.65
CD33+_Myeloid209.75
CD34+198.45
CD4+_Tcells202.05
CD56+_NKCells174.25
CD71+_EarlyErythroid177.35
CD8+_Tcells109.3
CardiacMyocytes250.9
Caudatenucleus186.25
Cerebellum164.45
CerebellumPeduncles268.55
CiliaryGanglion139.55
CingulateCortex227.3
Colorectaladenocarcinoma189
DorsalRootGanglion147.85
FetalThyroid209.5
Fetalbrain188.3
Fetalliver165.4
Fetallung157.1
GlobusPallidus144.8
Heart248.45
Hypothalamus204.7
Kidney167.7
Leukemia_chronicMyelogenousK-562171.1
Leukemia_promyelocytic-HL-60167.8
Leukemialymphoblastic(MOLT-4)153.35
Liver261.4
Lung206
Lymphnode165.15
Lymphoma_burkitts(Daudi)281.05
Lymphoma_burkitts(Raji)277.6
MedullaOblongata173.75
OccipitalLobe179.35
OlfactoryBulb149.25
Ovary142.6
Pancreas153.8
PancreaticIslet203.6
ParietalLobe240.3
Pituitary231.15
Placenta177.85
Pons290.1
PrefrontalCortex225.75
Prostate219.6
Salivarygland152.15
SkeletalMuscle374.15
Skin162.25
SmoothMuscle214.05
Spinalcord207.15
SubthalamicNucleus175.95
SuperiorCervicalGanglion218.75
TemporalLobe212.25
Testis164.85
TestisGermCell153.55
TestisIntersitial155.1
TestisLeydigCell204.75
TestisSeminiferousTubule163.2
Thalamus203.25
Thymus149
Thyroid235.8
Tongue237.3
Tonsil191.75
Trachea162.75
TrigeminalGanglion194.15
Uterus143.95
UterusCorpus183.2
WholeBlood222.25
Wholebrain155.25
colon182.55
pineal_day191.06
pineal_night184.9
retina239.225
small_intestine154.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P351069
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.47 ± 0.82
Basal Forebrain1.73 ± 0.36
Basal Part of Pons1.74 ± 0.71
Cerebellar Cortex1.93 ± 0.75
Cerebellar Nuclei2.07 ± 0.71
Claustrum2.35 ± 0.77
Epithalamus1.41 ± 0.68
Frontal Lobe1.87 ± 0.79
Globus Pallidus2.07 ± 0.92
Hypothalamus2.04 ± 0.99
Insula1.57 ± 0.51
Limbic Lobe2.06 ± 0.79
Mesencephalon1.99 ± 0.72
Myelencephalon1.97 ± 0.79
Occipital Lobe1.99 ± 0.76
Parietal Lobe2.02 ± 0.73
Pontine Tegmentum1.97 ± 0.73
Striatum1.72 ± 0.79
Subthalamus2.12 ± 0.17
Temporal Lobe1.85 ± 0.77
Thalamus1.73 ± 0.71
White Matter1.11 ± 0.36
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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