AutismKB 2.0

Annotation Detail for CLIC3


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Basic Information Top
Gene Symbol:CLIC3 ( - )
Gene Full Name: chloride intracellular channel 3
Band: 9q34.3
Quick LinksEntrez ID:9022; OMIM: 606533; Uniprot ID:CLIC3_HUMAN; ENSEMBL ID: ENSG00000169583; HGNC ID: 2064
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus25 / 56401244
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult24 / 193912112
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor9 / 26384534
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal52 / 336030715
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood1 / 1234788
bone0 / 716550 
bone marrow0 / 488010 
brain1 / 11009890 
cervix1 / 4817120
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye0 / 2110540 
heart3 / 8962633
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung16 / 33697447
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta27 / 28082596
prostate0 / 1893450 
salivary gland0 / 201550 
skin2 / 2105749
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219529_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.5
Adipocyte4.5
AdrenalCortex4.75
Adrenalgland3.8
Amygdala4.7
Appendix4.65
AtrioventricularNode3.7
BDCA4+_DentriticCells1223.05
Bonemarrow4.55
BronchialEpithelialCells25.55
CD105+_Endothelial4.55
CD14+_Monocytes5.5
CD19+_BCells(neg._sel.)6.75
CD33+_Myeloid5.8
CD34+5.6
CD4+_Tcells9.45
CD56+_NKCells1955
CD71+_EarlyErythroid4.25
CD8+_Tcells54.15
CardiacMyocytes6.25
Caudatenucleus4.1
Cerebellum3.7
CerebellumPeduncles5.15
CiliaryGanglion3.2
CingulateCortex4.6
Colorectaladenocarcinoma4.65
DorsalRootGanglion3.4
FetalThyroid435.8
Fetalbrain4.55
Fetalliver4
Fetallung92.45
GlobusPallidus3.35
Heart6.85
Hypothalamus4.9
Kidney3.75
Leukemia_chronicMyelogenousK-5624.1
Leukemia_promyelocytic-HL-604
Leukemialymphoblastic(MOLT-4)3.6
Liver6.2
Lung517.1
Lymphnode4.65
Lymphoma_burkitts(Daudi)5.75
Lymphoma_burkitts(Raji)6.55
MedullaOblongata4.1
OccipitalLobe4.05
OlfactoryBulb3.55
Ovary3
Pancreas3.65
PancreaticIslet4.85
ParietalLobe4.85
Pituitary5.35
Placenta960.8
Pons4.3
PrefrontalCortex5.55
Prostate7.15
Salivarygland3.65
SkeletalMuscle5.55
Skin3.5
SmoothMuscle5.1
Spinalcord6.55
SubthalamicNucleus4.2
SuperiorCervicalGanglion5.4
TemporalLobe4.15
Testis3.9
TestisGermCell3.75
TestisIntersitial3.8
TestisLeydigCell4.5
TestisSeminiferousTubule3.85
Thalamus4.6
Thymus16.35
Thyroid3040.25
Tongue254.55
Tonsil71.6
Trachea3.85
TrigeminalGanglion4.65
Uterus3.7
UterusCorpus4.15
WholeBlood7.7
Wholebrain3.85
colon4.6
pineal_day5.6
pineal_night5.48
retina5.5
small_intestine4.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1637_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.62 ± 1.18
Basal Forebrain2.25 ± 0.45
Basal Part of Pons2.09 ± 0.8
Cerebellar Cortex2.23 ± 0.99
Cerebellar Nuclei3.25 ± 0.79
Claustrum2.88 ± 0.74
Epithalamus2.87 ± 1.01
Frontal Lobe2.47 ± 0.81
Globus Pallidus2.85 ± 0.85
Hypothalamus2.14 ± 0.8
Insula2.2 ± 1.01
Limbic Lobe2.48 ± 0.9
Mesencephalon2.76 ± 0.91
Myelencephalon2.47 ± 0.75
Occipital Lobe2.48 ± 0.76
Parietal Lobe2.62 ± 0.92
Pontine Tegmentum2.72 ± 0.87
Striatum3.23 ± 0.75
Subthalamus2.65 ± 0.33
Temporal Lobe2.33 ± 0.89
Thalamus2.52 ± 0.71
White Matter2.58 ± 0.84
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Clic3CBCerebellum3.6
4.46
Clic3CTXCerebral cortex2.19
2.26
Clic3HIPHippocampal region2.69
2.61
Clic3HPFHippocampal formation2.9
2.72
Clic3HYHypothalamus0.4
0.36
Clic3LSXLateral septal complex0.04
0
Clic3MBMidbrain1.24
1.46
Clic3MYMedulla4.19
4.88
Clic3OLFOlfactory bulb1.6
1.66
Clic3PPons2.16
2.85
Clic3PALPallidum0.59
0.46
Clic3RHPRetrohippocampal region3.31
2.85
Clic3sAMYStriatum-like amygdalar nuclei1.57
1.4
Clic3STRStriatum1.06
1.21
Clic3STRdStriatum dorsal region1.26
1.6
Clic3STRvStriatum ventral region0.37
0.22
Clic3THThalamus2.11
1.91
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00010749 12 180 191 LHIVDTVCAHFR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018