AutismKB 2.0

Annotation Detail for BRSK2


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Basic Information Top
Gene Symbol:BRSK2 ( C11orf7,FLJ41362,PEN11B,SAD1,STK29 )
Gene Full Name: BR serine/threonine kinase 2
Band: 11p15.5
Quick LinksEntrez ID:9024; OMIM: 609236; Uniprot ID:BRSK2_HUMAN; ENSEMBL ID: ENSG00000174672; HGNC ID: 11405
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus10 / 56401217
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult14 / 19391217
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor8 / 26384530
glioma8 / 10688374
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor1 / 9635910
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal57 / 336030716
ovarian tumor2 / 7668226
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer0 / 1026800 
retinoblastoma7 / 46356151
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain51 / 110098946
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye17 / 21105480
heart0 / 896260 
intestine1 / 2344724
kidney0 / 2117770 
larynx0 / 241450 
liver1 / 2077434
lung3 / 3369748
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary2 / 10205119
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis5 / 33044215
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 215010_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.05
Adipocyte5.65
AdrenalCortex6.55
Adrenalgland4.95
Amygdala6.2
Appendix5.8
AtrioventricularNode4.6
BDCA4+_DentriticCells5.8
Bonemarrow5.65
BronchialEpithelialCells5.5
CD105+_Endothelial5.75
CD14+_Monocytes5.95
CD19+_BCells(neg._sel.)5.6
CD33+_Myeloid7.25
CD34+7.05
CD4+_Tcells6.15
CD56+_NKCells6.45
CD71+_EarlyErythroid5.4
CD8+_Tcells5.4
CardiacMyocytes7.6
Caudatenucleus7.55
Cerebellum6.8
CerebellumPeduncles13.95
CiliaryGanglion4.15
CingulateCortex5.9
Colorectaladenocarcinoma5.65
DorsalRootGanglion4.45
FetalThyroid5.5
Fetalbrain6.65
Fetalliver4.95
Fetallung4.45
GlobusPallidus6
Heart7.5
Hypothalamus6.25
Kidney4.75
Leukemia_chronicMyelogenousK-5625.25
Leukemia_promyelocytic-HL-605.1
Leukemialymphoblastic(MOLT-4)4.7
Liver7.65
Lung6.05
Lymphnode4.9
Lymphoma_burkitts(Daudi)7.35
Lymphoma_burkitts(Raji)8
MedullaOblongata5.6
OccipitalLobe6.3
OlfactoryBulb4.6
Ovary3.85
Pancreas4.65
PancreaticIslet6.2
ParietalLobe7.35
Pituitary6.9
Placenta5.7
Pons6.2
PrefrontalCortex10.2
Prostate6.65
Salivarygland4.6
SkeletalMuscle6.9
Skin4.5
SmoothMuscle6.4
Spinalcord6.2
SubthalamicNucleus8.2
SuperiorCervicalGanglion6.65
TemporalLobe5.4
Testis4.9
TestisGermCell4.9
TestisIntersitial4.8
TestisLeydigCell5.75
TestisSeminiferousTubule5
Thalamus5.85
Thymus4.2
Thyroid7.15
Tongue5.65
Tonsil5.6
Trachea4.8
TrigeminalGanglion5.9
Uterus4.7
UterusCorpus5.2
WholeBlood6.2
Wholebrain6.55
colon5.65
pineal_day7.46
pineal_night7.52
retina6.9
small_intestine5.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P328725
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.6 ± 0.34
Basal Forebrain5.14 ± 0.32
Basal Part of Pons5.64 ± 0.39
Cerebellar Cortex5.71 ± 0.27
Cerebellar Nuclei5.08 ± 0.52
Claustrum5.78 ± 0.58
Epithalamus4.36 ± 0.57
Frontal Lobe5.27 ± 0.49
Globus Pallidus4.38 ± 0.39
Hypothalamus4.87 ± 0.38
Insula5.48 ± 0.42
Limbic Lobe5.64 ± 0.42
Mesencephalon5.17 ± 0.56
Myelencephalon5.34 ± 0.54
Occipital Lobe5.59 ± 0.41
Parietal Lobe5.55 ± 0.48
Pontine Tegmentum5.31 ± 0.51
Striatum4.88 ± 0.34
Subthalamus5 ± 0.46
Temporal Lobe5.5 ± 0.41
Thalamus5.27 ± 0.46
White Matter4.7 ± 0.69
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Brsk2CBCerebellum13.16
14.05
Brsk2CTXCerebral cortex39.38
29.73
Brsk2HIPHippocampal region19.49
22.91
Brsk2HPFHippocampal formation17.57
17.92
Brsk2HYHypothalamus1.14
1.07
Brsk2LSXLateral septal complex1.82
1.35
Brsk2MBMidbrain5.94
6.24
Brsk2MYMedulla14.18
16.89
Brsk2OLFOlfactory bulb14.23
10.33
Brsk2PPons9.26
11.41
Brsk2PALPallidum2.94
2.88
Brsk2RHPRetrohippocampal region14.52
10.99
Brsk2sAMYStriatum-like amygdalar nuclei5.71
4.41
Brsk2STRStriatum3.74
2.86
Brsk2STRdStriatum dorsal region4.4
3.45
Brsk2STRvStriatum ventral region0.94
0.67
Brsk2THThalamus11.41
10.68
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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