AutismKB 2.0

Annotation Detail for DOK2


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Basic Information Top
Gene Symbol:DOK2 ( p56DOK,p56dok-2 )
Gene Full Name: docking protein 2, 56kDa
Band: 8p21.3
Quick LinksEntrez ID:9046; OMIM: 604997; Uniprot ID:DOK2_HUMAN; ENSEMBL ID: ENSG00000147443; HGNC ID: 2991
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus6 / 56401210
neonate2 / 3109764
infant0 / 236200 
juvenile0 / 555560 
adult58 / 193912129
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor4 / 26384515
glioma0 / 1068830 
head and neck tumor3 / 13630222
kidney tumor0 / 689590 
leukemia6 / 9584262
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia16 / 97250164
normal71 / 336030721
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood17 / 123478137
bone1 / 7165513
bone marrow0 / 488010 
brain2 / 11009891
cervix0 / 481710 
connective tissue17 / 149255113
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye4 / 21105418
heart0 / 896260 
intestine1 / 2344724
kidney1 / 2117774
larynx0 / 241450 
liver2 / 2077439
lung10 / 33697429
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth1 / 6705214
muscle0 / 1077150 
nerve0 / 157680 
ovary1 / 1020519
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta8 / 28082528
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen4 / 5395274
stomach2 / 9661920
testis1 / 3304423
thymus4 / 8113149
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus5 / 23287821
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 214054_at
Cell line Expression level Expression bar
721_B_lymphoblasts13.95
Adipocyte11.65
AdrenalCortex14.4
Adrenalgland11
Amygdala10.95
Appendix11.9
AtrioventricularNode15.1
BDCA4+_DentriticCells44.2
Bonemarrow13.5
BronchialEpithelialCells11.15
CD105+_Endothelial11.8
CD14+_Monocytes767.5
CD19+_BCells(neg._sel.)12.15
CD33+_Myeloid295.2
CD34+12.2
CD4+_Tcells92.9
CD56+_NKCells618.95
CD71+_EarlyErythroid9.4
CD8+_Tcells66.6
CardiacMyocytes14.75
Caudatenucleus10.7
Cerebellum9.5
CerebellumPeduncles13.15
CiliaryGanglion11.1
CingulateCortex13.35
Colorectaladenocarcinoma11.85
DorsalRootGanglion17.15
FetalThyroid9.95
Fetalbrain11.75
Fetalliver10.1
Fetallung9.8
GlobusPallidus8.75
Heart25.7
Hypothalamus12.3
Kidney9.4
Leukemia_chronicMyelogenousK-56213.15
Leukemia_promyelocytic-HL-6010
Leukemialymphoblastic(MOLT-4)9.3
Liver15.65
Lung95.5
Lymphnode13.85
Lymphoma_burkitts(Daudi)14.85
Lymphoma_burkitts(Raji)16.1
MedullaOblongata10.75
OccipitalLobe10.15
OlfactoryBulb9.35
Ovary7.8
Pancreas9.35
PancreaticIslet12.45
ParietalLobe12.45
Pituitary13.7
Placenta12.4
Pons11.1
PrefrontalCortex13.35
Prostate13.65
Salivarygland10.2
SkeletalMuscle16.8
Skin17.05
SmoothMuscle12.9
Spinalcord12.6
SubthalamicNucleus10.7
SuperiorCervicalGanglion16.8
TemporalLobe12.95
Testis10.05
TestisGermCell9.8
TestisIntersitial9.75
TestisLeydigCell13.35
TestisSeminiferousTubule11.4
Thalamus11.7
Thymus14.3
Thyroid14
Tongue11.55
Tonsil11.45
Trachea9.8
TrigeminalGanglion16.05
Uterus9.55
UterusCorpus13.6
WholeBlood193.4
Wholebrain9.35
colon11.4
pineal_day12.94
pineal_night12.6
retina14.025
small_intestine11.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14786_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.07 ± 1.1
Basal Forebrain1.6 ± 0.26
Basal Part of Pons1.55 ± 0.78
Cerebellar Cortex1.37 ± 0.7
Cerebellar Nuclei1.89 ± 0.8
Claustrum2.49 ± 0.95
Epithalamus1.53 ± 0.64
Frontal Lobe1.56 ± 0.75
Globus Pallidus2.31 ± 0.7
Hypothalamus1.72 ± 0.77
Insula1.72 ± 1.25
Limbic Lobe1.64 ± 0.81
Mesencephalon1.72 ± 0.74
Myelencephalon1.69 ± 0.71
Occipital Lobe1.6 ± 0.62
Parietal Lobe1.65 ± 0.76
Pontine Tegmentum1.7 ± 0.78
Striatum1.82 ± 0.72
Subthalamus1.78 ± 0.67
Temporal Lobe1.58 ± 0.84
Thalamus1.72 ± 0.78
White Matter1.87 ± 0.32
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dok2CBCerebellum4.06
3.67
Dok2CTXCerebral cortex2.77
2
Dok2HIPHippocampal region5.94
3.61
Dok2HPFHippocampal formation5.91
4.41
Dok2HYHypothalamus0.72
0.45
Dok2LSXLateral septal complex0.28
0.21
Dok2MBMidbrain1.03
1.15
Dok2MYMedulla1.27
1.05
Dok2OLFOlfactory bulb6.63
4.15
Dok2PPons1.28
1.17
Dok2PALPallidum1.47
1.13
Dok2RHPRetrohippocampal region6.24
5.61
Dok2sAMYStriatum-like amygdalar nuclei1.01
0.66
Dok2STRStriatum2.01
1.22
Dok2STRdStriatum dorsal region1.24
0.76
Dok2STRvStriatum ventral region6.37
3.4
Dok2THThalamus1.1
0.75
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
DOK2_HUMAN_0 0 0 0 CVSGEGNFEFETR PRIDE
DOK2_HUMAN_0 0 0 0 DKVTFSFEAGRR PRIDE
DOK2_HUMAN_204 12 204 215 DKVTFSFEAGRR PRIDE
DOK2_HUMAN_40 11 40 50 LELQEGPEKPR PRIDE
PAp00010070 15 26 40 FGASLYGGSDCALAR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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