AutismKB 2.0

Annotation Detail for SLC7A7


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Basic Information Top
Gene Symbol:SLC7A7 ( LAT3,LPI,MOP-2,Y+LAT1,y+LAT-1 )
Gene Full Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
Band: 14q11.2
Quick LinksEntrez ID:9056; OMIM: 603593; Uniprot ID:YLAT1_HUMAN; ENSEMBL ID: ENSG00000155465; HGNC ID: 11065
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst1 / 6231916
fetus14 / 56401224
neonate10 / 31097321
infant0 / 236200 
juvenile3 / 5555653
adult93 / 193912147
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor11 / 11424696
esophageal tumor1 / 1729057
gastrointestinal tumor5 / 11936941
germ cell tumor11 / 26384541
glioma2 / 10688318
head and neck tumor0 / 1363020 
kidney tumor11 / 68959159
leukemia4 / 9584241
liver tumor0 / 963590 
lung tumor7 / 10312767
lymphoma7 / 7175597
non-neoplasia31 / 97250318
normal309 / 336030791
ovarian tumor0 / 766820 
pancreatic tumor11 / 104616105
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood22 / 123478178
bone2 / 7165527
bone marrow0 / 488010 
brain35 / 110098931
cervix0 / 481710 
connective tissue34 / 149255227
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus1 / 2020949
eye1 / 2110544
heart1 / 8962611
intestine24 / 234472102
kidney122 / 211777576
larynx0 / 241450 
liver2 / 2077439
lung28 / 33697483
lymph1 / 4427022
lymph node1 / 9161010
mammary gland6 / 15327139
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary1 / 1020519
pancreas12 / 21481255
parathyroid3 / 20539146
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta49 / 280825174
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen28 / 53952518
stomach3 / 9661931
testis15 / 33044245
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord2 / 13680146
uterus8 / 23287834
vascular6 / 51780115
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204588_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts44
Adipocyte4.7
AdrenalCortex4.85
Adrenalgland4
Amygdala4.95
Appendix4.75
AtrioventricularNode3.9
BDCA4+_DentriticCells43.5
Bonemarrow4.9
BronchialEpithelialCells4.55
CD105+_Endothelial10.9
CD14+_Monocytes1046.5
CD19+_BCells(neg._sel.)20.3
CD33+_Myeloid1085.15
CD34+6.3
CD4+_Tcells5.2
CD56+_NKCells39.5
CD71+_EarlyErythroid5.9
CD8+_Tcells4.65
CardiacMyocytes5.95
Caudatenucleus4.35
Cerebellum3.85
CerebellumPeduncles5.35
CiliaryGanglion4.85
CingulateCortex4.85
Colorectaladenocarcinoma9.35
DorsalRootGanglion4.2
FetalThyroid4.7
Fetalbrain4.7
Fetalliver4.1
Fetallung7.3
GlobusPallidus3.45
Heart5.95
Hypothalamus5.15
Kidney265.95
Leukemia_chronicMyelogenousK-5624.3
Leukemia_promyelocytic-HL-604.2
Leukemialymphoblastic(MOLT-4)3.9
Liver6.2
Lung26.25
Lymphnode12.65
Lymphoma_burkitts(Daudi)7.75
Lymphoma_burkitts(Raji)6.55
MedullaOblongata4
OccipitalLobe4.25
OlfactoryBulb3.75
Ovary3.05
Pancreas3.85
PancreaticIslet5.15
ParietalLobe4.95
Pituitary5.6
Placenta5.05
Pons4.55
PrefrontalCortex5.9
Prostate5.55
Salivarygland4
SkeletalMuscle5.25
Skin3.95
SmoothMuscle8.7
Spinalcord5.7
SubthalamicNucleus4.25
SuperiorCervicalGanglion5.25
TemporalLobe4.35
Testis13.65
TestisGermCell17.6
TestisIntersitial38.5
TestisLeydigCell9.35
TestisSeminiferousTubule13.5
Thalamus4.85
Thymus3.85
Thyroid6.1
Tongue4.6
Tonsil6.3
Trachea4.05
TrigeminalGanglion4.75
Uterus4
UterusCorpus4.35
WholeBlood220.1
Wholebrain3.85
colon4.8
pineal_day5.94
pineal_night5.82
retina5.9
small_intestine15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P99642
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.13 ± 1.06
Basal Forebrain2.5 ± 0.43
Basal Part of Pons2.68 ± 0.87
Cerebellar Cortex1.53 ± 0.42
Cerebellar Nuclei3.24 ± 0.69
Claustrum2.41 ± 0.64
Epithalamus3.01 ± 0.36
Frontal Lobe1.97 ± 0.82
Globus Pallidus3.95 ± 0.68
Hypothalamus2.25 ± 0.86
Insula1.98 ± 0.6
Limbic Lobe1.83 ± 0.67
Mesencephalon2.13 ± 0.66
Myelencephalon2.17 ± 0.81
Occipital Lobe1.89 ± 0.73
Parietal Lobe2.14 ± 0.73
Pontine Tegmentum1.95 ± 0.74
Striatum2.82 ± 0.62
Subthalamus2.35 ± 0.24
Temporal Lobe2.07 ± 0.86
Thalamus2.2 ± 0.72
White Matter3.41 ± 0.91
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Slc7a7CBCerebellum1.27
2.5
Slc7a7CTXCerebral cortex0.21
0.46
Slc7a7HIPHippocampal region0.23
0.44
Slc7a7HPFHippocampal formation0.27
0.57
Slc7a7HYHypothalamus0.1
0.15
Slc7a7LSXLateral septal complex0.38
0.84
Slc7a7MBMidbrain0.23
0.45
Slc7a7MYMedulla0.42
0.66
Slc7a7OLFOlfactory bulb0.38
1.62
Slc7a7PPons0.5
0.98
Slc7a7PALPallidum0.06
0.08
Slc7a7RHPRetrohippocampal region0.3
0.68
Slc7a7sAMYStriatum-like amygdalar nuclei0.04
0.07
Slc7a7STRStriatum0.14
0.19
Slc7a7STRdStriatum dorsal region0.11
0.14
Slc7a7STRvStriatum ventral region0.22
0.21
Slc7a7THThalamus0.18
0.25
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
YLAT1_HUMAN_347 9 347 355 AICMIHVER PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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