AutismKB 2.0

Annotation Detail for PAPSS2


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Basic Information Top
Gene Symbol:PAPSS2 ( ATPSK2,SK2 )
Gene Full Name: 3'-phosphoadenosine 5'-phosphosulfate synthase 2
Band: 10q23.2-q23.31
Quick LinksEntrez ID:9060; OMIM: 603005; Uniprot ID:PAPS2_HUMAN; ENSEMBL ID: ENSG00000198682; HGNC ID: 8604
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst1 / 6231916
fetus38 / 56401267
neonate2 / 3109764
infant0 / 236200 
juvenile3 / 5555653
adult114 / 193912158
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor1 / 3436629
chondrosarcoma17 / 82823205
colorectal tumor15 / 114246131
esophageal tumor1 / 1729057
gastrointestinal tumor2 / 11936916
germ cell tumor3 / 26384511
glioma0 / 1068830 
head and neck tumor2 / 13630214
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor3 / 9635931
lung tumor16 / 103127155
lymphoma0 / 717550 
non-neoplasia10 / 97250102
normal216 / 336030764
ovarian tumor1 / 7668213
pancreatic tumor9 / 10461686
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland5 / 33197150
ascites0 / 400150 
bladder1 / 2975733
blood1 / 1234788
bone11 / 71655153
bone marrow1 / 4880120
brain13 / 110098911
cervix1 / 4817120
connective tissue23 / 149255154
ear1 / 1621261
embryonic tissue5 / 21572223
esophagus1 / 2020949
eye6 / 21105428
heart4 / 8962644
intestine24 / 234472102
kidney29 / 211777136
larynx0 / 241450 
liver14 / 20774367
lung37 / 336974109
lymph0 / 442700 
lymph node0 / 916100 
mammary gland5 / 15327132
mouth1 / 6705214
muscle4 / 10771537
nerve1 / 1576863
ovary2 / 10205119
pancreas28 / 214812130
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta34 / 280825121
prostate0 / 1893450 
salivary gland0 / 201550 
skin21 / 21057499
spleen0 / 539520 
stomach2 / 9661920
testis3 / 3304429
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus6 / 23287825
vascular14 / 51780270
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203058_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.7
Adipocyte32.85
AdrenalCortex270.75
Adrenalgland211.75
Amygdala8.25
Appendix11
AtrioventricularNode9.25
BDCA4+_DentriticCells7.75
Bonemarrow9.8
BronchialEpithelialCells8.05
CD105+_Endothelial8.25
CD14+_Monocytes9.05
CD19+_BCells(neg._sel.)8.35
CD33+_Myeloid9.8
CD34+9.55
CD4+_Tcells8.05
CD56+_NKCells8.95
CD71+_EarlyErythroid8.2
CD8+_Tcells7.1
CardiacMyocytes94.8
Caudatenucleus7.75
Cerebellum7.1
CerebellumPeduncles10.35
CiliaryGanglion9.45
CingulateCortex9
Colorectaladenocarcinoma8.3
DorsalRootGanglion8
FetalThyroid8.75
Fetalbrain7.8
Fetalliver29
Fetallung74.4
GlobusPallidus6.95
Heart15.05
Hypothalamus8.3
Kidney10.15
Leukemia_chronicMyelogenousK-5627.65
Leukemia_promyelocytic-HL-607.35
Leukemialymphoblastic(MOLT-4)6.3
Liver85.7
Lung121.35
Lymphnode9.9
Lymphoma_burkitts(Daudi)11.7
Lymphoma_burkitts(Raji)13.65
MedullaOblongata8.1
OccipitalLobe7.3
OlfactoryBulb7.25
Ovary7.7
Pancreas15.2
PancreaticIslet652.75
ParietalLobe9.8
Pituitary10.7
Placenta36.95
Pons8.7
PrefrontalCortex10.9
Prostate10.55
Salivarygland7.35
SkeletalMuscle13.75
Skin8.35
SmoothMuscle928.4
Spinalcord8.85
SubthalamicNucleus8.1
SuperiorCervicalGanglion13.6
TemporalLobe8.3
Testis9.35
TestisGermCell6.95
TestisIntersitial7.35
TestisLeydigCell9.1
TestisSeminiferousTubule7.15
Thalamus9
Thymus6.65
Thyroid46.4
Tongue9.9
Tonsil8.7
Trachea13.15
TrigeminalGanglion11.15
Uterus7.75
UterusCorpus8.95
WholeBlood9.75
Wholebrain6.45
colon238
pineal_day10.12
pineal_night10.88
retina11.075
small_intestine30.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P104493
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.31 ± 0.58
Basal Forebrain4.41 ± 0.58
Basal Part of Pons4 ± 0.39
Cerebellar Cortex3.75 ± 0.44
Cerebellar Nuclei4.7 ± 0.45
Claustrum3.76 ± 0.8
Epithalamus4.09 ± 0.61
Frontal Lobe4.33 ± 0.55
Globus Pallidus5.47 ± 0.46
Hypothalamus4.29 ± 0.63
Insula4.34 ± 0.56
Limbic Lobe4.11 ± 0.66
Mesencephalon4.55 ± 0.71
Myelencephalon4.41 ± 0.61
Occipital Lobe5.04 ± 0.55
Parietal Lobe4.29 ± 0.58
Pontine Tegmentum4.57 ± 0.67
Striatum4.76 ± 0.49
Subthalamus4.29 ± 0.13
Temporal Lobe4.54 ± 0.54
Thalamus4.48 ± 0.62
White Matter3.9 ± 0.23
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Papss2CBCerebellum3.78
6.01
Papss2CTXCerebral cortex1.52
1.68
Papss2HIPHippocampal region3.22
5.01
Papss2HPFHippocampal formation2.67
3.44
Papss2HYHypothalamus0.67
0.68
Papss2LSXLateral septal complex1.1
0.76
Papss2MBMidbrain1.22
1.28
Papss2MYMedulla1.53
1.6
Papss2OLFOlfactory bulb1.38
1.09
Papss2PPons1.75
1.72
Papss2PALPallidum1.24
1.28
Papss2RHPRetrohippocampal region1.9
1.53
Papss2sAMYStriatum-like amygdalar nuclei0.82
0.66
Papss2STRStriatum0.83
0.81
Papss2STRdStriatum dorsal region0.87
0.88
Papss2STRvStriatum ventral region0.51
0.63
Papss2THThalamus0.81
0.93
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAPS2_HUMAN_412 15 412 426 NPVHNGHALLMQDTR PRIDE
PAPS2_HUMAN_513 11 513 523 DPAGMPHPETK PRIDE
PAPS2_HUMAN_535 17 535 551 VLSMAPGLTSVEIIPFR PRIDE
PAPS2_HUMAN_561 9 561 569 AMDFYDPAR PRIDE
PAp00095931 14 42 55 GCTVWLTGLSGAGK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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