AutismKB 2.0

Annotation Detail for PIAS2


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Basic Information Top
Gene Symbol:PIAS2 ( MGC102682,MIZ1,PIASX,PIASX-ALPHA,PIASX-BETA,SIZ2,ZMIZ4,miz )
Gene Full Name: protein inhibitor of activated STAT, 2
Band: 18q21.1
Quick LinksEntrez ID:9063; OMIM: 603567; Uniprot ID:PIAS2_HUMAN; ENSEMBL ID: ENSG00000078043; HGNC ID: 17311
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst4 / 6231964
fetus8 / 56401214
neonate1 / 3109732
infant0 / 236200 
juvenile1 / 5555617
adult62 / 193912131
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor4 / 26384515
glioma1 / 1068839
head and neck tumor9 / 13630266
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor1 / 1031279
lymphoma3 / 7175541
non-neoplasia2 / 9725020
normal123 / 336030736
ovarian tumor1 / 7668213
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites1 / 4001524
bladder0 / 297570 
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain34 / 110098930
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue10 / 21572246
esophagus0 / 202090 
eye5 / 21105423
heart0 / 896260 
intestine0 / 2344720 
kidney4 / 21177718
larynx0 / 241450 
liver5 / 20774324
lung5 / 33697414
lymph0 / 442700 
lymph node0 / 916100 
mammary gland7 / 15327145
mouth5 / 6705274
muscle1 / 1077159
nerve0 / 157680 
ovary1 / 1020519
pancreas2 / 2148129
parathyroid7 / 20539340
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta0 / 2808250 
prostate6 / 18934531
salivary gland0 / 201550 
skin4 / 21057418
spleen3 / 5395255
stomach3 / 9661931
testis59 / 330442178
thymus1 / 8113112
thyroid4 / 4747384
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord0 / 136800 
uterus4 / 23287817
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 37433_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.25
Adipocyte6.55
AdrenalCortex8.3
Adrenalgland5.9
Amygdala7.15
Appendix8.4
AtrioventricularNode6.85
BDCA4+_DentriticCells6.85
Bonemarrow7
BronchialEpithelialCells6.6
CD105+_Endothelial6.95
CD14+_Monocytes7.5
CD19+_BCells(neg._sel.)7
CD33+_Myeloid8.3
CD34+8.75
CD4+_Tcells7.1
CD56+_NKCells8.2
CD71+_EarlyErythroid6.5
CD8+_Tcells6.8
CardiacMyocytes11
Caudatenucleus6.2
Cerebellum5.55
CerebellumPeduncles8.2
CiliaryGanglion6.5
CingulateCortex7.1
Colorectaladenocarcinoma6.85
DorsalRootGanglion6.2
FetalThyroid6.85
Fetalbrain6.55
Fetalliver6
Fetallung5.35
GlobusPallidus5.7
Heart10.4
Hypothalamus7.3
Kidney6.1
Leukemia_chronicMyelogenousK-5626.05
Leukemia_promyelocytic-HL-606.05
Leukemialymphoblastic(MOLT-4)5.2
Liver11.3
Lung7.3
Lymphnode5.65
Lymphoma_burkitts(Daudi)8.95
Lymphoma_burkitts(Raji)11
MedullaOblongata6.2
OccipitalLobe6.05
OlfactoryBulb5.3
Ovary5.05
Pancreas5.7
PancreaticIslet7.2
ParietalLobe7.5
Pituitary7.8
Placenta6.5
Pons7.05
PrefrontalCortex8.55
Prostate7.75
Salivarygland5.75
SkeletalMuscle9.3
Skin5.9
SmoothMuscle7.75
Spinalcord7.2
SubthalamicNucleus6.6
SuperiorCervicalGanglion10.6
TemporalLobe6.45
Testis5.75
TestisGermCell5.5
TestisIntersitial5.8
TestisLeydigCell7.25
TestisSeminiferousTubule5.85
Thalamus7.05
Thymus5.15
Thyroid8.25
Tongue7.35
Tonsil6.85
Trachea5.65
TrigeminalGanglion9.2
Uterus5.4
UterusCorpus6.75
WholeBlood7.5
Wholebrain5.35
colon6.9
pineal_day8.16
pineal_night8.02
retina8.35
small_intestine6.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P130316
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.05 ± 0.35
Basal Forebrain8.04 ± 0.1
Basal Part of Pons8.36 ± 0.11
Cerebellar Cortex8.1 ± 0.25
Cerebellar Nuclei8.36 ± 0.38
Claustrum8.27 ± 0.32
Epithalamus7.66 ± 0.52
Frontal Lobe8.19 ± 0.31
Globus Pallidus7.71 ± 0.24
Hypothalamus8.14 ± 0.21
Insula8.18 ± 0.27
Limbic Lobe8.13 ± 0.29
Mesencephalon8.07 ± 0.36
Myelencephalon8.02 ± 0.36
Occipital Lobe8.04 ± 0.25
Parietal Lobe8.21 ± 0.28
Pontine Tegmentum8.09 ± 0.28
Striatum8.14 ± 0.29
Subthalamus8.46 ± 0.16
Temporal Lobe8.03 ± 0.24
Thalamus7.99 ± 0.22
White Matter6.72 ± 0.18
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Pias2CBCerebellum82.17
100
Pias2CTXCerebral cortex100
100
Pias2HIPHippocampal region100
100
Pias2HPFHippocampal formation100
100
Pias2HYHypothalamus100
100
Pias2LSXLateral septal complex100
100
Pias2MBMidbrain100
100
Pias2MYMedulla86.39
100
Pias2OLFOlfactory bulb100
100
Pias2PPons93.32
100
Pias2PALPallidum100
100
Pias2RHPRetrohippocampal region100
100
Pias2sAMYStriatum-like amygdalar nuclei100
100
Pias2STRStriatum100
100
Pias2STRdStriatum dorsal region100
100
Pias2STRvStriatum ventral region100
100
Pias2THThalamus100
100
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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