AutismKB 2.0

Annotation Detail for MAP3K6


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Basic Information Top
Gene Symbol:MAP3K6 ( ASK2,MAPKKK6,MEKK6,MGC125653,MGC20114 )
Gene Full Name: mitogen-activated protein kinase kinase kinase 6
Band: 1p36.11
Quick LinksEntrez ID:9064; OMIM: 604468; Uniprot ID:M3K6_HUMAN; ENSEMBL ID: ENSG00000142733; HGNC ID: 6858
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus5 / 5640128
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult47 / 193912124
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor2 / 2638457
glioma1 / 1068839
head and neck tumor3 / 13630222
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor6 / 10312758
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal54 / 336030716
ovarian tumor1 / 7668213
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor7 / 12494956
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain6 / 11009895
cervix3 / 4817162
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye8 / 21105437
heart2 / 8962622
intestine7 / 23447229
kidney6 / 21177728
larynx1 / 2414541
liver1 / 2077434
lung8 / 33697423
lymph0 / 442700 
lymph node0 / 916100 
mammary gland6 / 15327139
mouth0 / 670520 
muscle1 / 1077159
nerve1 / 1576863
ovary1 / 1020519
pancreas8 / 21481237
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta6 / 28082521
prostate2 / 18934510
salivary gland2 / 2015599
skin12 / 21057456
spleen0 / 539520 
stomach8 / 9661982
testis2 / 3304426
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219278_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.65
Adipocyte5
AdrenalCortex3.85
Adrenalgland3.1
Amygdala3.95
Appendix3.7
AtrioventricularNode2.85
BDCA4+_DentriticCells4.15
Bonemarrow3.6
BronchialEpithelialCells3.7
CD105+_Endothelial3.8
CD14+_Monocytes4.1
CD19+_BCells(neg._sel.)4.1
CD33+_Myeloid4.8
CD34+4.75
CD4+_Tcells4.1
CD56+_NKCells4.45
CD71+_EarlyErythroid3.45
CD8+_Tcells3.9
CardiacMyocytes4.65
Caudatenucleus3.35
Cerebellum3
CerebellumPeduncles4.2
CiliaryGanglion2.75
CingulateCortex3.75
Colorectaladenocarcinoma3.75
DorsalRootGanglion2.8
FetalThyroid4.45
Fetalbrain3.7
Fetalliver3.15
Fetallung6.4
GlobusPallidus2.7
Heart4.65
Hypothalamus4.1
Kidney3
Leukemia_chronicMyelogenousK-5623.35
Leukemia_promyelocytic-HL-603.3
Leukemialymphoblastic(MOLT-4)3
Liver4.9
Lung49.35
Lymphnode3.25
Lymphoma_burkitts(Daudi)4.7
Lymphoma_burkitts(Raji)5.2
MedullaOblongata3.35
OccipitalLobe3.35
OlfactoryBulb2.95
Ovary2.5
Pancreas2.95
PancreaticIslet3.95
ParietalLobe3.85
Pituitary4.35
Placenta3.9
Pons3.6
PrefrontalCortex4.7
Prostate4.4
Salivarygland2.9
SkeletalMuscle4.15
Skin3.35
SmoothMuscle4.25
Spinalcord3.95
SubthalamicNucleus3.4
SuperiorCervicalGanglion4.15
TemporalLobe3.35
Testis3.2
TestisGermCell3.1
TestisIntersitial3.1
TestisLeydigCell3.65
TestisSeminiferousTubule3.2
Thalamus3.75
Thymus3
Thyroid4.75
Tongue3.6
Tonsil3.6
Trachea3.1
TrigeminalGanglion3.65
Uterus3.6
UterusCorpus3.3
WholeBlood4.1
Wholebrain3.15
colon3.75
pineal_day4.7
pineal_night4.58
retina7.125
small_intestine3.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P223017
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.53 ± 0.83
Basal Forebrain4.37 ± 0.2
Basal Part of Pons5.15 ± 0.33
Cerebellar Cortex5.16 ± 0.39
Cerebellar Nuclei4.43 ± 0.41
Claustrum4.61 ± 0.61
Epithalamus4.78 ± 0.47
Frontal Lobe4.54 ± 0.57
Globus Pallidus4.15 ± 0.45
Hypothalamus4.66 ± 0.42
Insula4.45 ± 0.33
Limbic Lobe4.16 ± 0.51
Mesencephalon4.5 ± 0.54
Myelencephalon4.55 ± 0.57
Occipital Lobe4.95 ± 0.46
Parietal Lobe4.77 ± 0.53
Pontine Tegmentum4.33 ± 0.55
Striatum3.96 ± 0.35
Subthalamus4.44 ± 0.42
Temporal Lobe4.42 ± 0.5
Thalamus4.91 ± 0.63
White Matter3.07 ± 0.35
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Map3k6CBCerebellum7.25
8.05
Map3k6CTXCerebral cortex6.41
4.77
Map3k6HIPHippocampal region5.94
6.48
Map3k6HPFHippocampal formation5.03
4.88
Map3k6HYHypothalamus0.6
1.33
Map3k6LSXLateral septal complex0.61
0.66
Map3k6MBMidbrain3
3.67
Map3k6MYMedulla6.76
7.85
Map3k6OLFOlfactory bulb4.19
2.86
Map3k6PPons3.61
4.65
Map3k6PALPallidum2.61
2.38
Map3k6RHPRetrohippocampal region3.42
2.65
Map3k6sAMYStriatum-like amygdalar nuclei7.71
5.57
Map3k6STRStriatum4.38
3.34
Map3k6STRdStriatum dorsal region4.6
3.6
Map3k6STRvStriatum ventral region2.92
2.1
Map3k6THThalamus6.33
8.54
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
M3K6_HUMAN_795 7 795 801 GPALLHR PRIDE
PAp00069868 7 1035 1041 HVEELLR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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