AutismKB 2.0

Annotation Detail for CLDN8


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Basic Information Top
Gene Symbol:CLDN8 ( - )
Gene Full Name: claudin 8
Band: 21q22.11
Quick LinksEntrez ID:9073; OMIM: 611231; Uniprot ID:CLD8_HUMAN; ENSEMBL ID: ENSG00000156284; HGNC ID: 2050
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus1 / 5640121
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult13 / 19391216
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor1 / 1729057
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal35 / 336030710
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer6 / 10268058
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain0 / 11009890 
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus1 / 2020949
eye0 / 2110540 
heart0 / 896260 
intestine9 / 23447238
kidney20 / 21177794
larynx0 / 241450 
liver0 / 2077430 
lung3 / 3369748
lymph0 / 442700 
lymph node0 / 916100 
mammary gland6 / 15327139
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate10 / 18934552
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid2 / 4747342
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 214598_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.9
Adipocyte6.05
AdrenalCortex7.05
Adrenalgland5.3
Amygdala6.15
Appendix8.4
AtrioventricularNode6.9
BDCA4+_DentriticCells6.7
Bonemarrow6.25
BronchialEpithelialCells6.05
CD105+_Endothelial6.25
CD14+_Monocytes6.6
CD19+_BCells(neg._sel.)6.55
CD33+_Myeloid7.95
CD34+7.65
CD4+_Tcells6.25
CD56+_NKCells7.3
CD71+_EarlyErythroid5.75
CD8+_Tcells5.5
CardiacMyocytes8.3
Caudatenucleus5.6
Cerebellum5
CerebellumPeduncles7.25
CiliaryGanglion5
CingulateCortex6.4
Colorectaladenocarcinoma6.1
DorsalRootGanglion6
FetalThyroid6.4
Fetalbrain5.95
Fetalliver5.35
Fetallung4.95
GlobusPallidus4.75
Heart8.15
Hypothalamus6.45
Kidney7.75
Leukemia_chronicMyelogenousK-5625.6
Leukemia_promyelocytic-HL-605.4
Leukemialymphoblastic(MOLT-4)4.9
Liver8.45
Lung6.7
Lymphnode5.25
Lymphoma_burkitts(Daudi)7.95
Lymphoma_burkitts(Raji)8.95
MedullaOblongata5.5
OccipitalLobe5.5
OlfactoryBulb4.8
Ovary4.4
Pancreas5.05
PancreaticIslet6.6
ParietalLobe6.6
Pituitary7.15
Placenta6.3
Pons6.1
PrefrontalCortex7.55
Prostate7.2
Salivarygland20.6
SkeletalMuscle7.9
Skin5.75
SmoothMuscle6.95
Spinalcord6.55
SubthalamicNucleus5.7
SuperiorCervicalGanglion11.45
TemporalLobe5.8
Testis5.25
TestisGermCell5.1
TestisIntersitial5.3
TestisLeydigCell6.25
TestisSeminiferousTubule5.3
Thalamus6.35
Thymus4.75
Thyroid9.85
Tongue7
Tonsil6.6
Trachea5.15
TrigeminalGanglion7.95
Uterus4.95
UterusCorpus6
WholeBlood6.65
Wholebrain5
colon10.05
pineal_day7.52
pineal_night7.42
retina7.4
small_intestine5.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_11526_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.29 ± 0.99
Basal Forebrain1.85 ± 0.21
Basal Part of Pons1.61 ± 0.47
Cerebellar Cortex1.74 ± 0.76
Cerebellar Nuclei2.17 ± 0.72
Claustrum2.72 ± 0.89
Epithalamus1.57 ± 0.7
Frontal Lobe1.66 ± 0.61
Globus Pallidus2.47 ± 0.33
Hypothalamus1.86 ± 0.69
Insula1.7 ± 0.47
Limbic Lobe1.84 ± 0.61
Mesencephalon1.99 ± 0.67
Myelencephalon1.87 ± 0.66
Occipital Lobe1.9 ± 0.55
Parietal Lobe1.87 ± 0.6
Pontine Tegmentum1.91 ± 0.72
Striatum1.99 ± 0.51
Subthalamus1.98 ± 0.65
Temporal Lobe1.79 ± 0.72
Thalamus1.84 ± 0.59
White Matter2.48 ± 0.49
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Cldn8CBCerebellum0
0
Cldn8CTXCerebral cortex0
0
Cldn8HIPHippocampal region0
0
Cldn8HPFHippocampal formation0
0
Cldn8HYHypothalamus0
0
Cldn8LSXLateral septal complex0
0
Cldn8MBMidbrain0
0
Cldn8MYMedulla0
0
Cldn8OLFOlfactory bulb0
0
Cldn8PPons0
0
Cldn8PALPallidum0
0
Cldn8RHPRetrohippocampal region0
0
Cldn8sAMYStriatum-like amygdalar nuclei0
0
Cldn8STRStriatum0
0
Cldn8STRdStriatum dorsal region0
0
Cldn8STRvStriatum ventral region0
0
Cldn8THThalamus0
0
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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