AutismKB 2.0

Annotation Detail for SPSB3


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Basic Information Top
Gene Symbol:SPSB3 ( C16orf31,SSB3 )
Gene Full Name: splA/ryanodine receptor domain and SOCS box containing 3
Band: 16p13.3
Quick LinksEntrez ID:90864; OMIM: 611659; Uniprot ID:SPSB3_HUMAN; ENSEMBL ID: ENSG00000162032; HGNC ID: 30629
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst8 / 62319128
fetus39 / 56401269
neonate2 / 3109764
infant2 / 2362084
juvenile3 / 5555653
adult155 / 193912179
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor1 / 3436629
chondrosarcoma3 / 8282336
colorectal tumor8 / 11424670
esophageal tumor2 / 17290115
gastrointestinal tumor34 / 119369284
germ cell tumor8 / 26384530
glioma5 / 10688346
head and neck tumor2 / 13630214
kidney tumor7 / 68959101
leukemia14 / 95842146
liver tumor6 / 9635962
lung tumor5 / 10312748
lymphoma0 / 717550 
non-neoplasia13 / 97250133
normal250 / 336030774
ovarian tumor6 / 7668278
pancreatic tumor54 / 104616516
primitive neuroectodermal tumor of the CNS10 / 12568079
prostate cancer2 / 10268019
retinoblastoma4 / 4635686
skin tumor6 / 12494948
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland1 / 3319730
ascites2 / 4001549
bladder0 / 297570 
blood19 / 123478153
bone5 / 7165569
bone marrow0 / 488010 
brain107 / 110098997
cervix7 / 48171145
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue13 / 21572260
esophagus2 / 2020998
eye12 / 21105456
heart3 / 8962633
intestine25 / 234472106
kidney14 / 21177766
larynx1 / 2414541
liver15 / 20774372
lung11 / 33697432
lymph0 / 442700 
lymph node23 / 91610251
mammary gland4 / 15327126
mouth3 / 6705244
muscle2 / 10771518
nerve3 / 15768190
ovary8 / 10205178
pancreas62 / 214812288
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta27 / 28082596
prostate6 / 18934531
salivary gland1 / 2015549
skin7 / 21057433
spleen4 / 5395274
stomach14 / 96619144
testis9 / 33044227
thymus12 / 81131147
thyroid1 / 4747321
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord1 / 1368073
uterus10 / 23287842
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 46256_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.95
Adipocyte5.2
AdrenalCortex14.1
Adrenalgland8.1
Amygdala7.85
Appendix7.05
AtrioventricularNode4.55
BDCA4+_DentriticCells73
Bonemarrow7.15
BronchialEpithelialCells6.8
CD105+_Endothelial47.2
CD14+_Monocytes68.7
CD19+_BCells(neg._sel.)56.45
CD33+_Myeloid57.2
CD34+63.7
CD4+_Tcells129.9
CD56+_NKCells146.25
CD71+_EarlyErythroid19.85
CD8+_Tcells126.6
CardiacMyocytes8.85
Caudatenucleus6.6
Cerebellum12.95
CerebellumPeduncles12.75
CiliaryGanglion4.4
CingulateCortex7.2
Colorectaladenocarcinoma7.35
DorsalRootGanglion4.8
FetalThyroid9.15
Fetalbrain12.45
Fetalliver5.55
Fetallung6.3
GlobusPallidus5.5
Heart19.8
Hypothalamus8.8
Kidney5.95
Leukemia_chronicMyelogenousK-5626.5
Leukemia_promyelocytic-HL-604.1
Leukemialymphoblastic(MOLT-4)10.4
Liver33.3
Lung33
Lymphnode14.4
Lymphoma_burkitts(Daudi)5.25
Lymphoma_burkitts(Raji)9.6
MedullaOblongata6.6
OccipitalLobe6.45
OlfactoryBulb6.15
Ovary3.55
Pancreas8.3
PancreaticIslet13.85
ParietalLobe6.8
Pituitary8.45
Placenta7.9
Pons5.3
PrefrontalCortex11.35
Prostate22.65
Salivarygland5.65
SkeletalMuscle7.9
Skin4.95
SmoothMuscle7.2
Spinalcord7.9
SubthalamicNucleus6.45
SuperiorCervicalGanglion7.45
TemporalLobe5.7
Testis6.95
TestisGermCell5.6
TestisIntersitial4.85
TestisLeydigCell5.6
TestisSeminiferousTubule4.8
Thalamus6.65
Thymus19.05
Thyroid17.55
Tongue7.65
Tonsil6.4
Trachea5.95
TrigeminalGanglion6.45
Uterus14.75
UterusCorpus6.25
WholeBlood32.7
Wholebrain16.45
colon7.1
pineal_day9.9
pineal_night10.36
retina9.475
small_intestine6.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P330537
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.73 ± 0.82
Basal Forebrain2.16 ± 0.55
Basal Part of Pons2.41 ± 0.68
Cerebellar Cortex3.11 ± 0.55
Cerebellar Nuclei2.4 ± 0.52
Claustrum2.74 ± 0.79
Epithalamus2.43 ± 0.75
Frontal Lobe2.57 ± 0.72
Globus Pallidus2.32 ± 0.6
Hypothalamus2.54 ± 0.6
Insula2.25 ± 0.84
Limbic Lobe2.41 ± 0.63
Mesencephalon2.55 ± 0.73
Myelencephalon2.54 ± 0.65
Occipital Lobe2.41 ± 0.66
Parietal Lobe2.56 ± 0.64
Pontine Tegmentum2.67 ± 0.63
Striatum2.15 ± 0.6
Subthalamus2.42 ± 0.64
Temporal Lobe2.5 ± 0.71
Thalamus2.55 ± 0.82
White Matter2.82 ± 0.46
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Spsb3CBCerebellum37.33
43.54
Spsb3CTXCerebral cortex76.28
60.97
Spsb3HIPHippocampal region37.77
48.1
Spsb3HPFHippocampal formation47.98
51.59
Spsb3HYHypothalamus13.39
11.47
Spsb3LSXLateral septal complex35.8
27.24
Spsb3MBMidbrain26.7
23.8
Spsb3MYMedulla26.33
27.05
Spsb3OLFOlfactory bulb55.14
47.96
Spsb3PPons27.54
30
Spsb3PALPallidum18.6
15.32
Spsb3RHPRetrohippocampal region62.46
55.32
Spsb3sAMYStriatum-like amygdalar nuclei17.75
12.66
Spsb3STRStriatum34.48
24.68
Spsb3STRdStriatum dorsal region39.08
28.37
Spsb3STRvStriatum ventral region28.13
18.77
Spsb3THThalamus58.26
55.89
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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