AutismKB 2.0

Annotation Detail for PKMYT1


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Basic Information Top
Gene Symbol:PKMYT1 ( DKFZp547K1610,FLJ20093,MYT1 )
Gene Full Name: protein kinase, membrane associated tyrosine/threonine 1
Band: 16p13.3
Quick LinksEntrez ID:9088; OMIM: 602474; Uniprot ID:PMYT1_HUMAN; ENSEMBL ID: ENSG00000127564; HGNC ID: 29650
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst3 / 6231948
fetus6 / 56401210
neonate3 / 3109796
infant4 / 23620169
juvenile20 / 55556359
adult70 / 193912136
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor9 / 9417895
cervical tumor3 / 3436687
chondrosarcoma1 / 8282312
colorectal tumor6 / 11424652
esophageal tumor2 / 17290115
gastrointestinal tumor5 / 11936941
germ cell tumor24 / 26384590
glioma9 / 10688384
head and neck tumor5 / 13630236
kidney tumor4 / 6895958
leukemia14 / 95842146
liver tumor7 / 9635972
lung tumor3 / 10312729
lymphoma18 / 71755250
non-neoplasia2 / 9725020
normal123 / 336030736
ovarian tumor2 / 7668226
pancreatic tumor11 / 104616105
primitive neuroectodermal tumor of the CNS61 / 125680485
prostate cancer3 / 10268029
retinoblastoma2 / 4635643
skin tumor11 / 12494988
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites1 / 4001524
bladder1 / 2975733
blood22 / 123478178
bone1 / 7165513
bone marrow2 / 4880140
brain53 / 110098948
cervix5 / 48171103
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue11 / 21572250
esophagus2 / 2020998
eye6 / 21105428
heart1 / 8962611
intestine12 / 23447251
kidney7 / 21177733
larynx0 / 241450 
liver8 / 20774338
lung6 / 33697417
lymph3 / 4427067
lymph node5 / 9161054
mammary gland10 / 15327165
mouth4 / 6705259
muscle1 / 1077159
nerve0 / 157680 
ovary3 / 10205129
pancreas11 / 21481251
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta16 / 28082556
prostate5 / 18934526
salivary gland0 / 201550 
skin13 / 21057461
spleen2 / 5395237
stomach3 / 9661931
testis67 / 330442202
thymus27 / 81131332
thyroid2 / 4747342
tonsil2 / 16999117
trachea0 / 524130 
umbilical cord1 / 1368073
uterus7 / 23287830
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204267_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts76.45
Adipocyte13.7
AdrenalCortex12.55
Adrenalgland10.05
Amygdala12.05
Appendix15
AtrioventricularNode8.8
BDCA4+_DentriticCells10.5
Bonemarrow14.3
BronchialEpithelialCells12.9
CD105+_Endothelial77.1
CD14+_Monocytes12.95
CD19+_BCells(neg._sel.)13.1
CD33+_Myeloid21.95
CD34+53.45
CD4+_Tcells12.9
CD56+_NKCells13.45
CD71+_EarlyErythroid129.35
CD8+_Tcells11.45
CardiacMyocytes14.25
Caudatenucleus10.8
Cerebellum9.95
CerebellumPeduncles13.4
CiliaryGanglion8.3
CingulateCortex12
Colorectaladenocarcinoma30.25
DorsalRootGanglion8.95
FetalThyroid17.4
Fetalbrain12.05
Fetalliver14
Fetallung10.2
GlobusPallidus8.65
Heart19.15
Hypothalamus12.7
Kidney9.8
Leukemia_chronicMyelogenousK-56235.1
Leukemia_promyelocytic-HL-6035
Leukemialymphoblastic(MOLT-4)52.65
Liver17.7
Lung12.9
Lymphnode10.55
Lymphoma_burkitts(Daudi)26.25
Lymphoma_burkitts(Raji)24.5
MedullaOblongata11.2
OccipitalLobe10.5
OlfactoryBulb9.5
Ovary7.85
Pancreas10.85
PancreaticIslet14.75
ParietalLobe12.4
Pituitary17.5
Placenta12.65
Pons17.85
PrefrontalCortex13.95
Prostate14.3
Salivarygland9.45
SkeletalMuscle13.85
Skin8.95
SmoothMuscle13.7
Spinalcord17.8
SubthalamicNucleus10.7
SuperiorCervicalGanglion13.25
TemporalLobe13.1
Testis46.4
TestisGermCell24.65
TestisIntersitial19.55
TestisLeydigCell22.7
TestisSeminiferousTubule31.3
Thalamus12
Thymus20.1
Thyroid14.4
Tongue11.55
Tonsil12.35
Trachea10.15
TrigeminalGanglion12.15
Uterus9.65
UterusCorpus13
WholeBlood12.9
Wholebrain10.1
colon12.1
pineal_day12.26
pineal_night10.26
retina13.85
small_intestine9.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P398515
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.64 ± 0.73
Basal Forebrain3.74 ± 0.63
Basal Part of Pons3.44 ± 0.73
Cerebellar Cortex3.85 ± 0.5
Cerebellar Nuclei3.69 ± 0.76
Claustrum4.28 ± 1.13
Epithalamus2.69 ± 0.47
Frontal Lobe3.41 ± 0.74
Globus Pallidus3.75 ± 0.79
Hypothalamus3.29 ± 0.56
Insula3.36 ± 0.65
Limbic Lobe3.6 ± 0.77
Mesencephalon3.57 ± 0.74
Myelencephalon3.55 ± 0.78
Occipital Lobe3.66 ± 0.74
Parietal Lobe3.57 ± 0.71
Pontine Tegmentum3.34 ± 0.65
Striatum3.22 ± 0.76
Subthalamus4.06 ± 0.32
Temporal Lobe3.39 ± 0.81
Thalamus3.63 ± 0.74
White Matter3.78 ± 0.24
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Pkmyt1CBCerebellum1.98
2.07
Pkmyt1CTXCerebral cortex5.24
2.75
Pkmyt1HIPHippocampal region1.24
0.97
Pkmyt1HPFHippocampal formation2.66
1.42
Pkmyt1HYHypothalamus0.35
0.16
Pkmyt1LSXLateral septal complex0.47
0.23
Pkmyt1MBMidbrain1.46
0.87
Pkmyt1MYMedulla6.04
3.56
Pkmyt1OLFOlfactory bulb2.91
1.44
Pkmyt1PPons7.29
5.87
Pkmyt1PALPallidum1.09
0.34
Pkmyt1RHPRetrohippocampal region4.78
2.01
Pkmyt1sAMYStriatum-like amygdalar nuclei0.05
0
Pkmyt1STRStriatum0.83
0.43
Pkmyt1STRdStriatum dorsal region0.65
0.45
Pkmyt1STRvStriatum ventral region1.88
0.57
Pkmyt1THThalamus3.62
4.28
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PMYT1_HUMAN_86 27 86 112 GEASETLQSPGYDPSRPESFFQQSFQR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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